公开(公告)号：US20240042093A1

公开(公告)日：2024-02-08

申请号：US18268786

申请日：2021-12-22

Applicant: FLUIDX MEDICAL TECHNOLOGY, INC.

Inventor： Russell J. Stewart ,  Joshua JONES ,  Shawn FOJTIK ,  Jessica KARZ

IPC: A61L24/00 ,  A61L24/06

CPC classification number: A61L24/0015 ,  A61L24/06 ,  A61L2300/106 ,  A61L2300/44 ,  A61L2400/06

Abstract: Described herein are injectable compositions composed of one or more polycationic polyelectrolytes and anionic counterions, one or more one polyanionic polyelectrolytes and cationic counterions, and a transient contrast agent. The injectable compositions have an ion concentration that is sufficient to prevent association of the polycationic polyelectrolytes and the polyanionic poly-electrolytes in water. Upon introduction of the composition into a subject, a solid is produced in situ. The transient contrast agent diffuses out of the solid over hours or days providing temporary contrast and does not remain in the subject unlike permanent contrast agents. This feature provides sufficient time for the clinician to perform medical procedures prior to the diffusion of the contrast agent out of the solid. The viscosity of the injectable compositions can be varied depending upon the application of the injectable composition. By varying the molecular weight, charge densities, and/or concentrations of the polycationic and polyanionic salts, it is possible to produce injectable compositions having a useful range of viscosities.