公开(公告)号：US12234147B2

公开(公告)日：2025-02-25

申请号：US18142220

申请日：2023-05-02

Applicant: Northwestern University ,  UChicago Argonne, LLC

Inventor： Mercouri G. Kanatzidis ,  Daniel G. Chica ,  Yihui He ,  Duck Young Chung

IPC: C01B25/14 ,  C30B23/00 ,  C30B29/46 ,  G01T1/24 ,  G01T3/08

Abstract: Inorganic compounds having the formula LiMP2Q6, where M is Ga, In, Bi, Sb, As, Al, or a combination thereof, and Q is S and/or Se, are provided. Methods and devices for detecting incident neutrons and alpha-particles using the compounds are also provided. For thermal neutron detection applications, the compounds can be enriched with lithium-6 isotope (6Li) to enhance their neutron detecting capabilities.

公开(公告)号：US12233080B2

公开(公告)日：2025-02-25

申请号：US17037079

申请日：2020-09-29

Applicant: Northwestern University

Inventor： Stephen F. Murphy ,  Praveen Thumbikat ,  Anthony Schaeffer

IPC: A61K39/085 ,  A61K9/00 ,  A61K31/7032 ,  A61K35/00 ,  A61K35/741 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06

Abstract: Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use thereof for the treatment of immune—(e.g., autoimmune) and inflammation-related conditions and diseases (e.g., chronic pelvic pain syndrome (CPPS), arthritis, etc.).

公开(公告)号：US12227650B2

公开(公告)日：2025-02-18

申请号：US17789177

申请日：2020-12-23

Applicant: DOW SILICONES CORPORATION ,  DOW GLOBAL TECHNOLOGIES LLC ,  NORTHWESTERN UNIVERSITY

Inventor： Dongchan Ahn ,  Jeremy Beebe ,  Shane Mangold ,  Ken Shull ,  Muzhou Wang ,  Anthony Silvaroli ,  Tyler Heyl

IPC: C08L83/04 ,  C08L83/06

Abstract: A method of preparing a silicone-acrylate hybrid composition is provided. The method comprises irradiating an acrylate composition in the presence of: (i) a silicone article, and/or (ii) a silicone composition; to polymerize the acrylate composition and give the silicone-acrylate hybrid composition. The acrylate composition comprises an acrylate compound and an initiator.

公开(公告)号：US12226410B2

公开(公告)日：2025-02-18

申请号：US17073603

申请日：2020-10-19

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Joseph R. Mazzulli ,  Leah K. Cuddy

IPC: A61K31/4709 ,  A61K31/454 ,  A61P25/16 ,  G01N33/68

Abstract: Disclosed are methods and compositions for enhancing cellular clearance of pathological molecules. Particularly disclosed are methods and compositions enhancing cellular clearance of pathological molecules via activating the cellular protein ykt6. The disclosed methods and compositions may be utilized in order to treat a subject having or at risk for developing a proteinopathy or other cellular storage disorder.

公开(公告)号：US20250049901A1

公开(公告)日：2025-02-13

申请号：US18927670

申请日：2024-10-25

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Lonnie D. Shea ,  Stephen Miller ,  Jonathan Woon Teck Yap ,  Daniel R. Getts ,  Derrick McCarthy

IPC: A61K39/00 ,  A61K9/16 ,  A61K9/19 ,  A61K9/51 ,  A61K47/58 ,  A61K47/69

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

公开(公告)号：US20250049393A1

公开(公告)日：2025-02-13

申请号：US18718693

申请日：2022-12-13

Applicant: Northwestern University

Inventor： Josiah David Hester ,  Alexander Curtiss ,  Blaine Rothrock ,  Nabil Iyad Alshurafa

IPC: A61B5/00 ,  A41D13/11 ,  A61B5/0205

Abstract: A smart face mask device includes a housing that is designed to mount to a personal protective face mask and a memory within the housing that is configured to store sensor data. The device includes one or more sensors configured to generate the sensor data during use of the personal protective mask. The device also includes a processor operatively coupled to the memory and configured to process the sensor data to determine information regarding a user of the personal protective mask, and to transmit the information regarding the user to a remote application.

公开(公告)号：US20250043032A1

公开(公告)日：2025-02-06

申请号：US18716928

申请日：2022-12-06

Applicant: Northwestern University ,  Cornell University

Inventor： William Robert Dichtel ,  Damian E. Helbling ,  Ri Wang ,  Max Justin Klemes

IPC: C08B37/16 ,  B01J20/26 ,  C02F1/28 ,  C02F101/36 ,  C08L5/16

Abstract: Disclosed herein are mesoporous polymeric materials and methods for preparing and using the same. The mesoporous polymeric material comprises a network of cyclodextrin moieties crosslinked by a plurality of crosslinks.

公开(公告)号：US12214340B2

公开(公告)日：2025-02-04

申请号：US18096758

申请日：2023-01-13

Applicant: UCHICAGO ARGONNE, LLC ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION ,  CORNELL UNIVERSITY ,  NORTHWESTERN UNIVERSITY, AN ILLINOIS NOT-FOR-PROFIT ORGANIZATION ,  IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

Inventor： Massimiliano Delferro ,  Magali S. Ferrandon ,  Kenneth R. Poeppelmeier ,  Aaron D. Sadow ,  Susannah Scott ,  Anne M. LaPointe ,  Geoffrey Coates

IPC: B01J23/42 ,  B01J23/00 ,  B01J35/23 ,  B01J35/40 ,  C08F8/50 ,  C08F10/02

Abstract: A method of upcycling polymers to useful hydrocarbon materials. A catalyst with nanoparticles on a substrate selectively docks and cleaves longer hydrocarbon chains over shorter hydrocarbon chains. The catalyst includes metal nanoparticles in an order array on a substrate.

公开(公告)号：US12214104B2

公开(公告)日：2025-02-04

申请号：US16646848

申请日：2018-09-13

Applicant: Northwestern University

Inventor： Guillermo A. Ameer ,  Henry Oliver Tenadooah Ware ,  Cheng Sun ,  Congwen Duan

IPC: A61L27/16 ,  A61L27/04 ,  A61L27/10 ,  A61L27/12 ,  A61L27/58 ,  B29C35/02 ,  B29C64/124 ,  B29C64/30 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/10 ,  B33Y80/00

Abstract: Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.

公开(公告)号：US20250034341A1

公开(公告)日：2025-01-30

申请号：US18775233

申请日：2024-07-17

Applicant: Northwestern University

Inventor： Daniel Ryan Hart ,  Julia A. Kalow ,  Joseph V. Accardo

IPC: C08J3/24 ,  C08F136/08 ,  C08G61/08 ,  C08K5/37

Abstract: Synthetic methods for forming a crosslinked polymer network with dynamic bonds within its crosslinks from a pre-existing unsaturated organic polymer are provided. The dynamic bonds enable the resulting crosslinked polymer network to be chemically or mechanically recycled or otherwise reprocessed. Also provided are crosslinked polymer networks made using the synthetic methods and methods for reprocessing the crosslinked polymer networks using thiol exchange reactions.