公开(公告)号：US20160144012A1

公开(公告)日：2016-05-26

申请号：US15012211

申请日：2016-02-01

Applicant: Northwestern University

Inventor： David Klumpp ,  Anthony Schaeffer ,  Benjamin Billips

IPC: A61K39/108

CPC classification number: A61K39/0258 ,  A61K35/74 ,  A61K35/744 ,  A61K2039/522

Abstract: The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Abstract translation: 本发明涉及通过施用活的减毒组合物进行疾病治疗和预防的组合物和方法。 特别地，本发明提供了通过施用缺乏O-抗原连接酶活性的活减毒组合物来治疗和预防尿路感染的组合物和方法。

公开(公告)号：US12233080B2

公开(公告)日：2025-02-25

申请号：US17037079

申请日：2020-09-29

Applicant: Northwestern University

Inventor： Stephen F. Murphy ,  Praveen Thumbikat ,  Anthony Schaeffer

IPC: A61K39/085 ,  A61K9/00 ,  A61K31/7032 ,  A61K35/00 ,  A61K35/741 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06

Abstract: Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use thereof for the treatment of immune—(e.g., autoimmune) and inflammation-related conditions and diseases (e.g., chronic pelvic pain syndrome (CPPS), arthritis, etc.).

公开(公告)号：US20210023109A1

公开(公告)日：2021-01-28

申请号：US17037079

申请日：2020-09-29

Applicant: Northwestern University

Inventor： Stephen F. Murphy ,  Praveen Thumbikat ,  Anthony Schaeffer

IPC: A61K31/7032 ,  A61K35/741 ,  A61P29/00 ,  A61P19/02 ,  A61K9/00 ,  A61P37/06

Abstract: Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use thereof for the treatment of immune- (e.g., autoimmune) and inflammation-related conditions and diseases (e.g., chronic pelvic pain syndrome (CPPS), arthritis, etc.).

公开(公告)号：US20180280419A1

公开(公告)日：2018-10-04

申请号：US15923679

申请日：2018-03-16

Applicant: Northwestern University

Inventor： Stephen F. Murphy ,  Praveen Thumbikat ,  Anthony Schaeffer

IPC: A61K31/7032 ,  A61K35/741 ,  A61P29/00 ,  A61P37/06 ,  A61P19/02 ,  A61K9/00

CPC classification number: A61K31/7032 ,  A61K9/0031 ,  A61K9/0053 ,  A61K35/741 ,  A61K2035/115 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06

Abstract: Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use thereof for the treatment of immune- (e.g., autoimmune) and inflammation-related conditions and diseases (e.g., chronic pelvic pain syndrome (CPPS), arthritis, etc.).

公开(公告)号：US10799520B2

公开(公告)日：2020-10-13

申请号：US15923679

申请日：2018-03-16

Applicant: Northwestern University

Inventor： Stephen F. Murphy ,  Praveen Thumbikat ,  Anthony Schaeffer

IPC: A61K31/7032 ,  A61K35/741 ,  A61P29/00 ,  A61P19/02 ,  A61K9/00 ,  A61P37/06 ,  A61K35/00

Abstract: Provided herein are compositions comprising lipotechoic acid (LTA) and methods of use thereof for immune modulation. In particular, compositions comprising S. epidermidis lipotechoic Acid (SELTA) are provided, as well as method of use thereof for the treatment of immune- (e.g., autoimmune) and inflammation-related conditions and diseases (e.g., chronic pelvic pain syndrome (CPPS), arthritis, etc.).

公开(公告)号：US09248175B2

公开(公告)日：2016-02-02

申请号：US14263276

申请日：2014-04-28

Applicant: Northwestern University

Inventor： David Klumpp ,  Anthony Schaeffer ,  Benjamin Billips

IPC: A61K39/108 ,  C12N1/20 ,  A61K35/74 ,  A61K35/744

CPC classification number: A61K39/0258 ,  A61K35/74 ,  A61K35/744 ,  A61K2039/522

Abstract: The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Abstract translation: 本发明涉及通过施用活的减毒组合物进行疾病治疗和预防的组合物和方法。 特别地，本发明提供了通过施用缺乏O-抗原连接酶活性的活减毒组合物来治疗和预防尿路感染的组合物和方法。

公开(公告)号：US20140234369A1

公开(公告)日：2014-08-21

申请号：US14263276

申请日：2014-04-28

Applicant: Northwestern University

Inventor： David Klumpp ,  Anthony Schaeffer ,  Benjamin Billips

IPC: A61K39/108

CPC classification number: A61K39/0258 ,  A61K35/74 ,  A61K35/744 ,  A61K2039/522

Abstract: The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration of a live attenuated compositions lacking O-antigen ligase activity.

Abstract translation: 本发明涉及通过施用活的减毒组合物进行疾病治疗和预防的组合物和方法。 特别地，本发明提供了通过施用缺乏O-抗原连接酶活性的活减毒组合物来治疗和预防尿路感染的组合物和方法。