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公开(公告)号：US12121618B2
公开(公告)日：2024-10-22
申请号：US17055640
申请日：2018-05-18
发明人： Geunbae Lim , Jungho Lee , Byoungsun Choi , Hyeonsu Woo
CPC分类号： A61K9/7092 , A61K9/0021 , A61M37/0015 , B29C33/3857 , B29C35/0805 , B29C41/50 , A61M2037/0046 , A61M2037/0053 , B29L2031/7544
摘要： A transdermal drug delivery patch includes a flexible base layer, and a plurality of microneedles disposed at one surface of the base layer and including a biodegradable polymer and a drug. Each of a plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a concave shape is formed between two protrusions adjacent along a circumferential direction among a plurality of protrusions.
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2.发明授权公开(公告)号：US12070567B2
公开(公告)日：2024-08-27
申请号：US17712755
申请日：2022-04-04
发明人： Andrew Tadros , Mark R. Prausnitz
IPC分类号： A61M37/00 , A61K8/02 , A61K9/00 , A61K31/352 , A61Q19/00
CPC分类号： A61M37/0015 , A61K8/0204 , A61K8/0245 , A61K9/0021 , A61K31/352 , A61Q19/00 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061
摘要： Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.
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公开(公告)号：US12064520B2
公开(公告)日：2024-08-20
申请号：US17694852
申请日：2022-03-15
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer
IPC分类号： A61K9/48 , A61B5/145 , A61B10/02 , A61B10/06 , A61J3/07 , A61K9/00 , A61K38/28 , A61M5/142 , A61M5/145 , A61M5/158 , A61M5/20 , A61M5/32 , A61M31/00 , A61M37/00 , A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61K9/4808 , A61B5/14503 , A61B5/14539 , A61B10/02 , A61J3/07 , A61K9/0002 , A61K9/0012 , A61K9/0021 , A61K9/0065 , A61K9/0092 , A61K9/4866 , A61K38/28 , A61M5/14276 , A61M5/1454 , A61M5/158 , A61M5/2033 , A61M5/329 , A61M5/3295 , A61M31/002 , A61M37/0015 , A61M37/0069 , A61N1/325 , A61N1/36007 , A61B2010/0208 , A61B10/0233 , A61B10/06 , A61M2005/14284 , A61M2005/1581 , A61M2005/1585 , A61M2037/0023 , A61M2037/0053 , A61M2205/0238 , A61M2205/21 , A61M2210/1053 , A61M2210/106 , A61N1/0509
摘要： Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component (e.g., having a relatively high API loading).
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公开(公告)号：US20240238569A1
公开(公告)日：2024-07-18
申请号：US18239752
申请日：2023-08-29
发明人： Ashwin Pushpala , Alan Szmodis , Matthew Chapman , Weldon Hall , Scott Miller , Hooman Hafezi
IPC分类号： A61M37/00 , A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/1495 , A61B5/15 , A61M25/00 , C12Q1/00 , G01N27/327
CPC分类号： A61M37/0015 , A61B5/14503 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150282 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/4839 , A61B5/685 , C12Q1/006 , G01N27/3271 , A61B2562/028 , A61B2562/12 , A61B2562/125 , A61M25/00 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , Y10T29/49117
摘要： A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.
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公开(公告)号：US20240238486A1
公开(公告)日：2024-07-18
申请号：US18454628
申请日：2023-08-23
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , Carnegie Mellon University
CPC分类号： A61L31/148 , A61L31/042 , A61L31/06 , A61L31/16 , A61M37/0015 , B23C3/00 , A61L2300/426 , A61L2300/604 , A61L2400/06 , A61M2037/0053 , B23C2215/00 , B23C2220/48 , B23C2226/00 , Y10T409/303752
摘要： A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.
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公开(公告)号：US20240207590A1
公开(公告)日：2024-06-27
申请号：US18543180
申请日：2023-12-18
发明人： Geunbae LIM , Jungho LEE
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053
摘要： A microneedle patch according to one embodiment of the present disclosure includes: a base including an invasive part and a non-invasive part; and a microneedle located in the invasive part of the base, wherein at least a portion of the microneedle is loaded with drug, and no microneedle is located in the non-invasive part.
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公开(公告)号：US12017031B2
公开(公告)日：2024-06-25
申请号：US17504718
申请日：2021-10-19
IPC分类号： A61M37/00 , A61B17/20 , A61K9/00 , A61K9/70 , A61K38/17 , A61K38/19 , B29C59/00 , B29C59/02 , B29L31/00
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61K9/7023 , A61K38/1793 , A61K38/191 , B29C59/002 , B29C59/026 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , A61M2037/0061 , B29C2059/023 , B29K2995/0056 , B29L2031/7544 , B29L2031/756 , Y10T156/10 , Y10T156/1039 , Y10T156/1057
摘要： A medical device for delivering a drug compound through a stratum corneum includes a support having an aperture, an array of microneedles extending outwardly from the support, a plurality of nanostructures associated with each microneedle, and a reservoir wherein the drug compound is retained. At least one microneedle contains a shaft extending from the support. The shaft includes a tip configured to penetrate the stratum corneum. The shaft defines a channel extending from the support to the tip. The channel is in at least partial alignment with the aperture. At least some of the microneedles of the array of microneedles each have a cross-sectional dimension of from about 1 micrometer to about 1 millimeter. At least some of the nanostructures have a cross-sectional dimension less than about 500 nanometers and greater than about 5 nanometers and an aspect ratio of from about 0.2 to about 5.
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公开(公告)号：US20240149034A1
公开(公告)日：2024-05-09
申请号：US18415729
申请日：2024-01-18
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
摘要： A system, apparatus and method for a tightly sealed, low moisture vapor transmission, low relative humidity headspace atmosphere aseptic vaccine delivery with low particulate generation. The system can include a housing, desiccant and a biasing member designed to quickly and efficiently deliver medicament to a patient.
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公开(公告)号：US11951272B2
公开(公告)日：2024-04-09
申请号：US17443523
申请日：2021-07-27
发明人： Chenjie Xu , Hao Chang
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , A61M2202/03 , A61M2202/07 , A61M2202/203 , A61M2202/206 , A61M2202/30 , A61M2210/0612
摘要： A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.
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公开(公告)号：US11896792B2
公开(公告)日：2024-02-13
申请号：US16722977
申请日：2019-12-20
发明人： Ashwin Pushpala , Alan Szmodis , Matthew Chapman , Weldon Hall , Scott Miller , Hooman Hafezi
IPC分类号： A61B5/05 , A61M37/00 , G01N27/327 , A61B5/15 , A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/1495 , C12Q1/00 , A61M25/00
CPC分类号： A61M37/0015 , A61B5/1495 , A61B5/14503 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/150022 , A61B5/150282 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/4839 , A61B5/685 , C12Q1/006 , G01N27/3271 , A61B2562/028 , A61B2562/12 , A61B2562/125 , A61M25/00 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , Y10T29/49117
摘要： A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.
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