Methods for ensuring resuspension of paliperidone palmitate formulations

    公开(公告)号:US11666697B2

    公开(公告)日:2023-06-06

    申请号:US17534837

    申请日:2021-11-24

    摘要: Provided are methods for improving resuspendability of a paliperidone palmitate extended-release injectable suspension within a syringe, for reducing a force required for injection of a paliperidone palmitate extended-release injectable suspension, or for reducing the likelihood of incomplete injection of a paliperidone palmitate extended-release injectable suspension comprising maintaining the syringe in a desired orientation during shipping of the syringe that varies from the orientation of the syringe during pre-shipping storage. Also provided are populations of syringes that respectively contain paliperidone palmitate extended release injectable suspension, wherein each of the syringes have been shipped to a destination, and the syringes were each maintained in a desired orientation during shipping of the syringe that varies from the orientation of the syringe during pre-shipping storage. The present disclosure also provides pharmaceutical products comprising a paliperidone palmitate extended-release injectable suspension within a syringe for administration to a patient suffering from schizophrenia, wherein the syringe has undergone pre-shipping storage and has been shipped, and wherein the syringe has been maintained in an orientation during the shipping that varies from the orientation of the syringe during pre-shipping storage.

    Reduced-Pressure, Multi-Orientation, Liquid-Collection Canister

    公开(公告)号:US20180028727A1

    公开(公告)日:2018-02-01

    申请号:US15729446

    申请日:2017-10-10

    IPC分类号: A61M1/00

    摘要: A liquid-collection canister includes a liquid collection chamber defined by at least one wall and a first and second gas-communication pathway formed within the at least one wall. A first aperture is positioned between the first gas-communication pathway and the liquid collection chamber to allow gaseous communication between the liquid collection chamber and the first gas-communication pathway. A second aperture is positioned between the second gas-communication pathway and the liquid collection chamber to allow gaseous communication between the liquid collection chamber and the second gas-communication pathway. A first and a second liquid-air separator are positioned over the first aperture and the second aperture, respectively, to substantially prevent liquid passing through the first and second apertures.

    HUMIDIFICATION DEVICE, HUMIDIFIER AND VENTILATOR

    公开(公告)号:US20180001050A1

    公开(公告)日:2018-01-04

    申请号:US15542438

    申请日:2015-12-31

    发明人: Lijun LIU Zhi ZHUANG

    IPC分类号: A61M16/16 A61M16/10 A61M16/00

    摘要: The present disclosure discloses a humidification device, a humidifier and a ventilator, overcoming the deficiency that when the structure of a water tank of a current ventilator causes the water tank to tilt or sway, it is easy for a large amount of water to enter a heating portion. The humidification device comprises a heating portion and a liquid inlet structure adding liquid to the heating portion. The heating portion comprises an accommodating chamber and a transition chamber limiting the amount of liquid in the accommodating chamber, and the liquid inlet structure is communicated with the transition chamber and allows the liquid to enter the transition chamber. According to embodiments of the present disclosure, a large amount of stored water may be prevented from entering the heating portion and thus affecting the heating efficiency when a water tank or a similar humidification device tilts.