-
1.发明公开公开(公告)号：US20230347124A1
公开(公告)日：2023-11-02
申请号：US18329399
申请日：2023-06-05
发明人： Yunhua Gao , Zequan Zhou , Suohui Zhang , Guozhong Yang
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.
-
2.发明公开公开(公告)号：US20240293653A1
公开(公告)日：2024-09-05
申请号：US18661731
申请日：2024-05-13
申请人： TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES , Beijing CAS Microneedle Technology Ltd.
发明人： Yunhua Gao , Mengzhen Xing
CPC分类号： A61M37/0015 , A61L31/048 , A61L31/145 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
摘要： A hydrogel microneedle patch based on a three-dimensional framework structure is provided and includes a hydrogel microneedle. A raw material of the hydrogel microneedle includes polyvinyl alcohol and aqueous dispersion of acrylic resin. the hydrogel microneedle is obtained by uniformly mixing and molding of the aqueous dispersion of acrylic resin and the polyvinyl alcohol. The hydrogel microneedle patch has good strength, excellent swelling property and puncture property. In addition, a preparation method and an application of hydrogel microneedle patch are also provided.
-
3.发明授权公开(公告)号：US11801373B1
公开(公告)日：2023-10-31
申请号：US18329399
申请日：2023-06-05
发明人： Yunhua Gao , Zequan Zhou , Suohui Zhang , Guozhong Yang
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.
-
公开(公告)号：US20210178138A1
公开(公告)日：2021-06-17
申请号：US17271881
申请日：2019-08-29
发明人： Yunhua GAO , Meilin HE , Guozhong YANG , Suohui ZHANG
IPC分类号： A61M37/00 , A61K47/34 , A61K47/38 , A61K47/32 , A61K47/02 , A61K47/26 , A61K9/00 , B29C45/16
摘要： An implantable sustained-release microneedle patch and a preparation method therefor. The implantable sustained-release microneedle comprises a needle tip, a needle body, and a base. The needle tip comprises a needle tip center layer and a needle tip outer layer. The needle tip center layer is formed of a matrix comprising a biodegradable water-insoluble polymer material. The needle tip outer layer, the needle body, and the base are formed of a matrix comprising a water-soluble polymer material. The microneedle patch comprises the microneedle and absorbs the moisture of the skin when the microneedle acts on skin, so that the base and the needle body are quickly separated from the needle tip within 0.5-2 h. After the base is removed, the needle tip will be left in skin, and the user does not need the patch sticking for a long time to ensure long-term release of a drug in the body.
-
-
-
搜索结果
4 条记录 (耗时 0.011 秒)
