公开(公告)号：US12097113B2

公开(公告)日：2024-09-24

申请号：US17115812

申请日：2020-12-09

申请人： Sichuan University

发明人： Yunbing Wang ,  Gaoyang Guo ,  Li Yang

IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/54 ,  A61L31/00 ,  A61L33/00 ,  A61L33/04

CPC分类号： A61F2/2415 ,  A61F2/2418 ,  A61L27/3625 ,  A61L27/3687 ,  A61L27/54 ,  A61L31/005 ,  A61L33/0023 ,  A61L33/0041 ,  A61L33/04 ,  A61L2300/208 ,  A61L2430/20

摘要： A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

公开(公告)号：US20240181138A1

公开(公告)日：2024-06-06

申请号：US18282535

申请日：2022-03-09

申请人： Hubei Sailuo Biological Material Co., Ltd

发明人： Chunyu Chang ,  Lin Wu ,  Yu Pan ,  Jiehan Lin

IPC分类号： A61L31/00 ,  A61L31/12 ,  A61L31/14

CPC分类号： A61L31/005 ,  A61L31/127 ,  A61L31/148 ,  A61L2400/12 ,  A61L2430/02

摘要： The present invention relates to a silk fibroin/hydroxyapatite composite material, and a preparation method therefor and an application thereof. A uniform mixture of hydroxyapatite nanoparticles, silk fibroin, and hexafluoroisopropanol is maintained at a temperature range from 50° C. to 60° C. for at least 1 hour to obtain a silk fibroin/hydroxyapatite solution; the silk fibroin/hydroxyapatite solution is poured into a long cylindrical mold, two ends of the long cylindrical mold being respectively an end A and an end B; at room temperature, the end A is opened and the end B is closed, and the mold is vertically immersed in methanol with the opening facing up and let stand for at least 2 days; the mold is turned upside down, the end A is closed and the end B is opened, and the mold is vertically immersed in the methanol with the opening facing up and let stand for at least 2 days; the mold is removed, and ventilation and drying are performed to obtain a silk fibroin/hydroxyapatite composite material. The silk fibroin/hydroxyapatite composite material prepared in the present invention has uniform strength, good mechanical properties, and significant osteoinductivity.

公开(公告)号：US11925731B2

公开(公告)日：2024-03-12

申请号：US17896525

申请日：2022-08-26

申请人： Texas Medical Center

发明人： Timothy J. Keane, Jr. ,  Peter Alexander Smith ,  Stephen G. Ramon

IPC分类号： A61L31/14 ,  A61L31/00 ,  A61L31/04

CPC分类号： A61L31/145 ,  A61L31/005 ,  A61L31/041 ,  A61L2400/06

摘要： Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 μm. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.

公开(公告)号：US20240024541A1

公开(公告)日：2024-01-25

申请号：US18234438

申请日：2023-08-16

申请人： BIOMEDIX, S.A.

发明人： Norman GODIN

IPC分类号： A61L31/00 ,  A61F5/00 ,  A61L31/02 ,  A61L31/08 ,  A61L31/16

CPC分类号： A61L31/005 ,  A61F5/0076 ,  A61L31/022 ,  A61L31/08 ,  A61L31/16 ,  A61L2430/22 ,  A61L2300/30 ,  A61L2300/64

摘要： A method for maintaining a medical device in place in a lumen of a hollow organ of a patient for a period of months or years includes not using a metal or bioresorbable self-expandable stent. Optionally, a platelet rich plasma (PRP) solution can be applied to a stent to integrate the stent into an interior passageway of a patient. The stent can optionally be formed of a nitinol and inserted through a mouth of the patient. Sutures can be used to attach the stent to the interior passageway of the patient.

公开(公告)号：US20190216977A1

公开(公告)日：2019-07-18

申请号：US16256147

申请日：2019-01-24

申请人： LifeCell Corporation

发明人： Hui Xu ,  Wendell Sun ,  Cunqi Cui ,  Hua Wan

IPC分类号： A61L27/36 ,  A61L31/00 ,  A61L27/38

CPC分类号： A61L27/3675 ,  A61L27/3625 ,  A61L27/3834 ,  A61L31/005 ,  A61L2430/32 ,  A61L2430/40

摘要： Devices and methods for treating defects in peripheral nerves are provided. The devices can include acellular arterial tissue matrices that facilitate regrowth of nerve tissue across a gap or defect in a peripheral nerve.

公开(公告)号：US20190209327A1

公开(公告)日：2019-07-11

申请号：US16326246

申请日：2017-08-16

申请人： FITZBIONICS LIMITED

发明人： Noel Fitzpatrick ,  Jayantilal Meswania ,  Gordon Blunn

IPC分类号： A61F2/28 ,  A61L27/56

CPC分类号： A61F2/2846 ,  A61B17/68 ,  A61B17/8061 ,  A61B2017/00004 ,  A61F2/28 ,  A61F2002/2835 ,  A61F2002/30011 ,  A61F2002/30433 ,  A61F2002/30462 ,  A61F2002/30578 ,  A61F2002/30677 ,  A61F2002/307 ,  A61F2002/30774 ,  A61F2002/30962 ,  A61L27/06 ,  A61L27/56 ,  A61L31/005 ,  A61L31/041 ,  A61L31/044 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/64 ,  A61L2430/02 ,  C08L67/04 ,  C08L89/06 ,  C08L5/08

摘要： An implant for repairing a segmental defect in a subject's bone at a segmental defect site, the implant comprising a scaffold for implantation at the segmental defect site and the implant optionally comprising: a plate for internal fixation, the plate being attachable to or integral with the scaffold, and the plate having means for securing it to bone outside of the segmental defect site; a hollow cavity within the scaffold; a plurality of longitudinal channels within the scaffold; and or a membrane received around the scaffold.

公开(公告)号：US20180327120A1

公开(公告)日：2018-11-15

申请号：US15946524

申请日：2018-04-05

申请人： Antoine Turzi

发明人： Antoine Turzi

IPC分类号： B65B3/00 ,  C08L5/08 ,  A61K31/722 ,  B65B3/02 ,  A61L33/08 ,  A61L33/00 ,  A61L31/16 ,  A61L31/04 ,  A61L31/00 ,  A61L27/54 ,  A61L27/36 ,  A61L27/20 ,  A61L24/08 ,  A61L24/00 ,  B65B43/54 ,  A61K35/19 ,  A61K31/728

CPC分类号： B65B3/003 ,  A61K31/722 ,  A61K31/728 ,  A61K35/19 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/08 ,  A61L27/20 ,  A61L27/3616 ,  A61L27/54 ,  A61L31/005 ,  A61L31/042 ,  A61L31/16 ,  A61L33/00 ,  A61L33/0011 ,  A61L33/08 ,  A61L2300/42 ,  B65B3/022 ,  B65B43/54 ,  A61K2300/00 ,  C08L5/08

摘要： The present invention is related to the field of tissue regeneration. It concerns more particularly new manufacturing machines and processes, new A-PRP or PRP, hyaluronic acid and/or chitosan compositions, used alone or in combination, and related devices.

公开(公告)号：US20170312389A1

公开(公告)日：2017-11-02

申请号：US15652566

申请日：2017-07-18

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G. Matheny

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61F2/02 ,  A61L27/22 ,  A61L27/34 ,  A61F2/00 ,  A61L27/50 ,  A61L27/54 ,  A61L31/00 ,  A61L31/14 ,  A61L31/16 ,  A61N1/375 ,  A61F2/24 ,  A61K38/18 ,  A61K38/00 ,  A61K35/42 ,  A61K35/38 ,  A61K35/37 ,  A61K35/22 ,  A61K35/12

CPC分类号： A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

摘要： A tissue prosthesis comprising an extracellular matrix (ECM) composition, the ECM composition comprising decellularized ECM derived from mesothelial tissue and an exogenously added basic fibroblast growth factor (bFGF).

公开(公告)号：US20170203003A1

公开(公告)日：2017-07-20

申请号：US15326747

申请日：2015-07-28

申请人： REPUBLIC OF KOREA (MANAGEMENT:RURAL DEVELOPMENT ADMINISTRATION)

发明人： You Young JO ,  Hae Yong KWEON ,  Kwang Gill LEE ,  Joo Hong YEO ,  Heui Sam LEE

IPC分类号： A61L27/36 ,  A61K35/64 ,  A61L27/54

CPC分类号： A61L27/3604 ,  A61C8/0006 ,  A61K35/63 ,  A61K35/64 ,  A61L27/365 ,  A61L27/3691 ,  A61L27/54 ,  A61L31/005 ,  A61L2300/412 ,  A61L2430/12

摘要： Disclosed herein are a cocoon-based, dental barrier membrane for guided bone regeneration and a method for manufacturing the same. The cocoon-based, dental barrier membrane is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a first thickness. The dental barrier membrane is biocompatible, has excellent tensile strength and porosity, and promotes osteogenesis in a bone defect.

公开(公告)号：US09682171B2

公开(公告)日：2017-06-20

申请号：US14833354

申请日：2015-08-24

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61F13/00 ,  A61K35/12 ,  A61K35/34 ,  A61L33/00 ,  A61L27/36 ,  A61L31/00 ,  A61L27/38 ,  A61F2/00 ,  A61L27/34 ,  A61F2/02 ,  A61L27/54 ,  A61L31/16 ,  A61L27/50 ,  A61L31/14 ,  A61N1/375 ,  A61L27/22 ,  A61K35/38 ,  A61K35/22 ,  A61F2/24 ,  A61K38/00 ,  A61K35/42

CPC分类号： A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

摘要： A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.