公开(公告)号：US11666606B2

公开(公告)日：2023-06-06

申请号：US16746541

申请日：2020-01-17

Applicant: Prime Merger Sub, LLC

Inventor： Jeffrey S. White ,  Robin R. Young

IPC: A61K35/50 ,  A61K38/57 ,  A61L27/54 ,  A61L27/36 ,  A61K9/00 ,  A61K47/36

CPC classification number: A61K35/50 ,  A61K38/57 ,  A61L27/3604 ,  A61L27/54 ,  A61K9/0019 ,  A61K47/36 ,  A61L2300/434 ,  A61L2430/24

Abstract: Methods for treating joint diseases, disorders, and conditions, such as osteoarthritis, with a composition containing a therapeutically effective amount of tissue inhibitors of matrix metalloproteinases (TIMPs) are provided. The composition can contain TIMPs as part of amniotic fluid, or the TIMPs can be isolated from another source or recombinantly produced. The methods are particularly useful for treating osteoarthritis associated with degradation of articular cartilage by proteases. Also provided are methods of lubricating a joint, such as an osteoarthritic joint.

公开(公告)号：US20180344905A1

公开(公告)日：2018-12-06

申请号：US16101413

申请日：2018-08-11

Applicant: The Administrators of the Tulane Educational Fund

Inventor： Diane A. BLAKE ,  Vijay T. John ,  Ramesh Ayyala ,  Thiruselvam Ponnusamy

IPC: A61L31/16 ,  C08L71/02 ,  C08L67/04 ,  A61K9/70 ,  A61K31/216 ,  A61K31/407 ,  A61K31/513 ,  A61K47/34 ,  A61L31/10 ,  A61L31/14 ,  B29C39/00 ,  B29C39/08 ,  B29D7/01 ,  B29C39/12 ,  A61M37/00 ,  A61F9/007 ,  B29K33/00

CPC classification number: A61L31/16 ,  A61F9/00781 ,  A61K9/7007 ,  A61K31/216 ,  A61K31/407 ,  A61K31/513 ,  A61K47/34 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2420/06 ,  A61L2420/08 ,  A61M37/00 ,  B29C39/003 ,  B29C39/08 ,  B29C39/123 ,  B29D7/01 ,  B29K2033/00 ,  B29K2995/0056 ,  B29K2995/006 ,  C08L71/02 ,  C08L67/04 ,  A61K2300/00

Abstract: The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.

公开(公告)号：US20180256783A1

公开(公告)日：2018-09-13

申请号：US15978376

申请日：2018-05-14

Applicant: CorMatrix Cardiovascular, Inc.

Inventor： Robert G. Matheny

IPC: A61L27/36 ,  A61N1/375 ,  A61L27/38 ,  A61F2/02 ,  A61L27/22 ,  A61L27/34 ,  A61F2/00 ,  A61L27/50 ,  A61L27/54 ,  A61L31/00 ,  A61L31/14 ,  A61L31/16 ,  A61F2/24 ,  A61K38/18 ,  A61K38/00 ,  A61K35/42 ,  A61K35/38 ,  A61K35/37 ,  A61K35/22 ,  A61K35/12

CPC classification number: A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

Abstract: A CO2 processed sheet structure comprising ECM derived from mammalian submucosa tissue, which can be formed into a pouch configured to encase a medical device.

公开(公告)号：US20180193412A1

公开(公告)日：2018-07-12

申请号：US15833171

申请日：2017-12-06

Applicant: Hexima Limited

Inventor： Nicole Louise Van der Weerden ,  Marilyn Anne Anderson

IPC: A61K38/16 ,  A61P31/10 ,  A61P31/04 ,  A61K45/06 ,  A61L31/10

CPC classification number: A61K38/168 ,  A61K38/1729 ,  A61K38/55 ,  A61K45/06 ,  A61L27/54 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/434 ,  A61P31/04 ,  A61P31/10 ,  C07K14/415 ,  A61K2300/00

Abstract: The present disclosure teaches the treatment or prophylaxis of infection by a microorganism including a fungus or bacterium which is infecting or colonizing an in vivo tissue, surface or membrane. The method comprising administering to the subject with the infection or directly to the site of infection a plant-derived defensin or a functional variant or derivative thereof.

公开(公告)号：US20180177830A1

公开(公告)日：2018-06-28

申请号：US15902084

申请日：2018-02-22

Applicant: CorMatrix Cardiovascular, Inc.

Inventor： Robert G. Matheny

IPC: A61K35/35 ,  A61K35/12 ,  A61M1/12 ,  A61L27/54 ,  A61L27/38 ,  A61L27/36 ,  A61K48/00 ,  A61K45/06 ,  A61K38/18

CPC classification number: A61K35/35 ,  A61K35/12 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/367 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/64 ,  A61L2430/20 ,  A61M1/122 ,  A61M2205/05

Abstract: ECM based compositions including acellular ECM and antibiotics, and methods for employing same to treat damaged cardiovascular tissue and, thereby, disorders.

公开(公告)号：US20180140752A1

公开(公告)日：2018-05-24

申请号：US15577027

申请日：2016-05-27

Applicant: Toray Industries, Inc.

Inventor： Koji Kadowaki ,  Akihiro Saito ,  Megumi Nakanishi ,  Masaki Fujita ,  Kazuhiro Tanahashi

IPC: A61L33/00 ,  C08L67/00 ,  C08K3/30 ,  C08K5/42 ,  G01N23/2273

CPC classification number: A61L33/0035 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  A61L33/0011 ,  A61L33/0023 ,  A61L33/0029 ,  A61L33/064 ,  A61L33/08 ,  A61L33/128 ,  A61L2300/42 ,  A61L2300/434 ,  A61L2420/08 ,  C08K3/30 ,  C08K5/42 ,  C08L67/00 ,  C08L2203/02 ,  G01N23/2273 ,  C08L79/02 ,  C08L5/10 ,  C08L67/02

Abstract: An antithrombogenic material includes a coating material containing: a cationic polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; and a base material whose surface is coated with the coating material; wherein the cationic polymer is covalently bound to the base material; the anionic compound containing a sulfur atom and having anticoagulant activity is immobilized on the surface of the base material by ionic bonding to the cationic polymer; and the average thickness of the coating material is 15 to 400 nm.

公开(公告)号：US20180140678A1

公开(公告)日：2018-05-24

申请号：US15640063

申请日：2017-06-30

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： James Yoo ,  Sang Jin Lee ,  Anthony Atala ,  Mark Van Dyke

IPC: A61K38/39 ,  A61K38/48 ,  A61L27/24 ,  A61L27/52 ,  A61K9/00 ,  A61L27/54

CPC classification number: A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K2300/00

Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

公开(公告)号：US09814799B2

公开(公告)日：2017-11-14

申请号：US14560329

申请日：2014-12-04

Applicant: Omrix Biopharmaceuticals Ltd.

Inventor： Yair Pilpel ,  Ashley Deanglis ,  Yuri Zherdev ,  Sivan Doron ,  Israel Nur

IPC: A61L24/00 ,  A61L24/10

CPC classification number: A61L24/001 ,  A61L24/0015 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/25 ,  A61L2300/434 ,  A61L2400/06

Abstract: Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.

公开(公告)号：US20170304507A1

公开(公告)日：2017-10-26

申请号：US15496297

申请日：2017-04-25

Applicant: AZIYO MED, LLC

Inventor： Robert G. Matheny

IPC: A61L31/00 ,  A61N1/375 ,  A61L31/04 ,  A61L31/16 ,  A61F2/00 ,  A61F2/24

CPC classification number: A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

Abstract: A sheet structure formed from an extracellular matrix (ECM) composition that includes acellular ECM derived from small intestine submucosa (SIS) tissue, gentamicin and vancomycin. The sheet structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when the tissue structure is delivered to the damaged biological tissue.

公开(公告)号：US09744264B2

公开(公告)日：2017-08-29

申请号：US14571639

申请日：2014-12-16

Applicant: CorMatrix Cardiovascular, Inc.

Inventor： Robert G Matheny

IPC: A61F2/00 ,  A61K35/42 ,  A61L27/36 ,  A61L31/00 ,  A61L27/38 ,  A61L27/34 ,  A61F2/02 ,  A61L27/54 ,  A61L31/16 ,  A61L27/50 ,  A61L31/14 ,  A61N1/375 ,  A61L27/22 ,  A61K35/38 ,  A61K35/12 ,  A61K35/22 ,  A61F2/24 ,  A61K38/00 ,  A61K35/37 ,  A61K38/18

CPC classification number: A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.