-
公开(公告)号：US12194196B2
公开(公告)日：2025-01-14
申请号：US16861104
申请日：2020-04-28
Applicant: University of Washington
Inventor： Buddy D. Ratner , Le Zhen , Felix Simonovsky , Jonathan Himmelfarb
Abstract: Synthetic polymeric vascular grafts that promote endothelial healing and methods of their preparation and use are provided.
-
公开(公告)号：US20250009934A1
公开(公告)日：2025-01-09
申请号：US18709960
申请日：2022-11-11
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Abstract: The present disclosure provides a vascular graft comprising i) one or more extracellular matrix compositions and ii) one or more hydrogels. In particular, the vascular grafts of the present disclosure can be functionalized and/or be completely biologic. The disclosure also provides methods of administering the vascular grafts as well as methods for forming the vascular grafts.
-
公开(公告)号：US20240423819A1
公开(公告)日：2024-12-26
申请号：US18685168
申请日：2022-08-22
Applicant: SUZHOU LAVAMED CO., LTD.
Inventor： Xin Hua , Liam Farrissey , Brendan Cunniffe , Quan Shen
Abstract: A medical device is provided, comprising: an expandable tubular member comprising a plurality of elements forming a sidewall, wherein each of the elements crosses one or more other elements and a plurality of pores are formed among the elements in the sidewall; wherein an antithrombogenic material is coated over the tubular member such that there is inherently no webbing of the antithrombogenic material between any two elements.
-
公开(公告)号：US20240374794A1
公开(公告)日：2024-11-14
申请号：US18778274
申请日：2024-07-19
Applicant: COVALON TECHNOLOGIES, LTD.
Inventor： Daryl Sivakumaran , Daryl Knight , Vyacheslav Dudnyk , Valerio DiTizio
IPC: A61L33/00 , A61L33/06 , C08F220/06 , C09D4/00 , C09D5/14 , C09D133/10
Abstract: A coating composition comprises an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer, wherein the at least one neutral monomer has a glass transition temperature of less than about 100° C. in homopolymeric form. A device comprises a protonated polyacrylate coating, wherein the device is inherently antimicrobial, anti-thrombogenic, flexible, and/or sheds few to no particulates.
-
公开(公告)号：US12097113B2
公开(公告)日：2024-09-24
申请号：US17115812
申请日：2020-12-09
Applicant: Sichuan University
Inventor： Yunbing Wang , Gaoyang Guo , Li Yang
CPC classification number: A61F2/2415 , A61F2/2418 , A61L27/3625 , A61L27/3687 , A61L27/54 , A61L31/005 , A61L33/0023 , A61L33/0041 , A61L33/04 , A61L2300/208 , A61L2430/20
Abstract: A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.
-
Patent Agency Ranking
公开(公告)号：US20240247115A1
公开(公告)日：2024-07-25
申请号：US18415889
申请日：2024-01-18
Applicant: Becton, Dickinson and Company
Inventor： Leandro Forciniti
IPC: C08J5/18 , A61L29/08 , A61L29/16 , A61L33/00 , C08F299/00
CPC classification number: C08J5/18 , A61L29/085 , A61L29/16 , A61L33/0011 , A61L33/0094 , C08F299/00 , A61L2300/236 , A61L2300/42 , C08J2353/00
Abstract: Provided are conductive films including a heparin modified polymer. The heparin modified polymer comprises heparin covalently bound to a beta-substituted monomer having a conjugated backbone that is co-polymerized to its non-functionalized pair. The heparin modified polymer on a conductive film can be manufactured by co-polymerizing a beta-substituted monomer with a non-functionalized monomer to form a polymer on a conductive film. The polymer is reacted with N,N′-Dicyclohexylcarbodiimide (DCC) and acetic acid to form an anhydride of the polymer on the conductive film. The anhydride is then reacted with heparin to form the heparin modified polymer on the conductive film. Medical devices having a coating comprising the conductive film are also described.
-
公开(公告)号：US20240216587A1
公开(公告)日：2024-07-04
申请号：US18244351
申请日：2023-09-11
Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education , Ri.MED Foundation
Inventor： Antonio D'Amore , Matteo Solazzo , William R. Wagner
CPC classification number: A61L31/047 , A61L31/125 , A61L31/146 , A61L31/148 , A61L31/16 , A61L33/0005 , A61L2430/22 , A61L2430/40
Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.
-
公开(公告)号：US20240138838A1
公开(公告)日：2024-05-02
申请号：US18317780
申请日：2023-05-15
Applicant: Washington University
Inventor： Xiaowei Li , Justin Sacks , William Moritz , Emran Madatov , Mohamed Zayed
CPC classification number: A61B17/11 , A61L31/041 , A61L33/0011 , A61L33/08 , A61B2017/00893
Abstract: An anastomosis device for joining a first and second end of a vascular vessel is disclosed that includes a polymer cylinder ending in opposed first and second vascular-retaining ends configured for insertion into the first and second ends of the vascular vessel respectively. Each vascular-retaining end includes a plurality of bristles protruding outward. The device also includes at least one moiety covalently coupled to the surface of the device. The at least one moiety is selected from at least one anti-coagulant, at least one cell-specific binding peptide, and any combination thereof.
-
公开(公告)号：US20240066189A1
公开(公告)日：2024-02-29
申请号：US17948711
申请日：2022-09-20
Inventor： Bin ZHENG , Haojun FAN , Bowen LI , Tingting HUA
CPC classification number: A61L33/0029 , A61L27/34 , A61L33/0041 , C08L27/06 , C08L69/00 , A61L2420/02
Abstract: Disclosed is a high anticoagulation extracorporeal circulation tube, which include the following preparation methods: S1, firstly, aminating the surface of the tube by extrusion molding; S2, activating heparin groups by a direct coupling method; S3, heparinizing PVC or PC tubes; S4, then, using albumin, functionalized PEG which can react with amino groups, and phosphate to further surface modify the inner wall of heparinized PVC or PC tube to block the sites not modified by heparinization, so as to shield the adsorption of platelets and protein in blood on the inner wall. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.
-
公开(公告)号：US11850335B2
公开(公告)日：2023-12-26
申请号：US17335130
申请日：2021-06-01
Applicant: Medtronic ATS Medical, Inc.
Inventor： Brian Pederson
CPC classification number: A61L33/0094 , A61L33/0041 , A61L33/062 , A61L33/126 , A61L33/128 , A61N1/05 , A61L2300/42 , A61N1/375 , A61N1/37512 , Y10T428/31768
Abstract: A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.
-
-
-
-
-
-
-
-
-
Search Results
1660
records
(took 0.025 seconds)
