公开(公告)号：US20240247115A1

公开(公告)日：2024-07-25

申请号：US18415889

申请日：2024-01-18

申请人： Becton, Dickinson and Company

发明人： Leandro Forciniti

IPC分类号： C08J5/18 ,  A61L29/08 ,  A61L29/16 ,  A61L33/00 ,  C08F299/00

CPC分类号： C08J5/18 ,  A61L29/085 ,  A61L29/16 ,  A61L33/0011 ,  A61L33/0094 ,  C08F299/00 ,  A61L2300/236 ,  A61L2300/42 ,  C08J2353/00

摘要： Provided are conductive films including a heparin modified polymer. The heparin modified polymer comprises heparin covalently bound to a beta-substituted monomer having a conjugated backbone that is co-polymerized to its non-functionalized pair. The heparin modified polymer on a conductive film can be manufactured by co-polymerizing a beta-substituted monomer with a non-functionalized monomer to form a polymer on a conductive film. The polymer is reacted with N,N′-Dicyclohexylcarbodiimide (DCC) and acetic acid to form an anhydride of the polymer on the conductive film. The anhydride is then reacted with heparin to form the heparin modified polymer on the conductive film. Medical devices having a coating comprising the conductive film are also described.