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    Extracorporeal blood circulation device
    2.
    发明授权
    Extracorporeal blood circulation device 有权

    公开(公告)号：US11819599B2

    公开(公告)日：2023-11-21

    申请号：US17117736

    申请日：2020-12-10

    Applicant: Infomed SA

    Inventor： Olivier Favre

    IPC: A61M1/36 ,  A61L33/04 ,  A61L33/12

    CPC classification number: A61M1/3672 ,  A61L33/04 ,  A61L33/128 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/502 ,  A61M2205/52

    Abstract: Disclosed is an extracorporeal blood circulation device including a blood circulation circuit including a blood extraction line and a return line, a blood circulator in the circulation circuit and a control unit including a calculator arranged determining at least one parameter, recording it in a memory, and then comparing the standard value of the parameter with the recorded value. The device also includes a source of solution for liquefying blood clots, a device injecting and conveying the liquefaction solution in the circulation circuit, the control unit including a driver for the injector of the liquefaction solution. The control unit is arranged to actuate the driver when the value is exceeded, meaning that at least one clot has formed, the driver being arranged so that the liquefaction solution is present in the circulation circuit in an amount and for a time determined to be sufficient for liquefying the clot formed.

    BIOPROSTHETIC VALVE AND PREPARATION METHOD THEREOF
    4.
    发明申请
    BIOPROSTHETIC VALVE AND PREPARATION METHOD THEREOF 有权

    公开(公告)号：US20210338420A1

    公开(公告)日：2021-11-04

    申请号：US17115812

    申请日：2020-12-09

    Applicant: Sichuan University

    Inventor： Yunbing Wang ,  Gaoyang Guo ,  Li Yang

    IPC: A61F2/24 ,  A61L27/36 ,  A61L27/54 ,  A61L33/00 ,  A61L33/12

    Abstract: A bioprosthetic valve and a preparation method thereof are provided. The bioprosthetic valve includes a stent and a functional biological tissue material attached to the stent. The functional biological tissue material is a biologicaltissue covalently bonded with an active group and a functional molecule or group. The method improves the anti-thrombosis and anti-calcification functions by covalently modifying the surface of a biological valve using an active group and a functional molecule or group with a substantial degree of grafting. The new bioprosthetic valve does not include aldehyde residues, exhibits excellent biocompatibility, optimal mechanical properties, high stability, and can meet the performance requirements of a biological valve delivered through a catheter.

    GELS FOR ENCAPSULATION OF BIOLOGICAL MATERIALS
    8.
    发明申请
    GELS FOR ENCAPSULATION OF BIOLOGICAL MATERIALS 审中-公开
    凝胶生物材料的凝胶

    公开(公告)号：US20080274201A1

    公开(公告)日：2008-11-06

    申请号：US12172063

    申请日：2008-07-11

    Applicant: Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F.A. Hossainy

    Inventor： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Syed F.A. Hossainy

    IPC: C12N11/04 ,  C08F2/46 ,  C08G59/02 ,  C08G65/02 ,  A61L33/06 ,  A61L33/08 ,  A61L33/12 ,  A61L33/16 ,  C08G73/00 ,  C08K5/04 ,  C08K5/16 ,  A61K9/50 ,  C08K5/07 ,  C08K5/34

    CPC classification number: A61K9/5073 ,  A61K9/5031 ,  A61K47/60 ,  A61K47/645 ,  A61K47/6925

    Abstract: This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.

    Abstract translation: 本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。 该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。 提供了形成这些膜的几种方法。 这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子。 大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。 该反应通过悬浮聚合或通过界面聚合进行。 聚合物膜可以直接形成在生物材料的表面上，或者可以在已经被包封的材料上形成。

    Methods of making and using surfactant polymers
    9.
    发明申请
    Methods of making and using surfactant polymers 有权
    制造和使用表面活性剂聚合物的方法

    公开(公告)号：US20050008603A1

    公开(公告)日：2005-01-13

    申请号：US10823218

    申请日：2004-04-13

    Applicant: Roger Marchant ,  Tianhong Zhang ,  Yongxing Qiu ,  Mark Ruegsegger

    Inventor： Roger Marchant ,  Tianhong Zhang ,  Yongxing Qiu ,  Mark Ruegsegger

    IPC: A61L27/34 ,  A61L31/10 ,  A61L33/00 ,  A61L33/08 ,  A61L33/12 ,  C07K5/09 ,  C07K5/10 ,  C07K7/06 ,  C08B37/02 ,  C08F8/00 ,  A61K7/06 ,  A61K7/11 ,  C08G63/48 ,  C08G63/91

    CPC classification number: C07K7/06 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0017 ,  A61L33/08 ,  A61L33/128 ,  C07K5/0817 ,  C07K5/1019 ,  C08B37/0021 ,  C08F8/00 ,  C08F26/02 ,  C08F16/06

    Abstract: Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.

    Abstract translation: 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包括具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团连接到所述主链的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 疏水侧链包括含有2至18个亚甲基的烷基。 烷基通过酯键，仲胺键或优选酰胺键与聚合物主链相连。 亲水侧链选自：中性寡糖，其优选具有小于7000的重均分子量; 带电荷的寡糖，优选具有小于10,000的重均分子量的带负电荷的寡糖; 所述寡肽具有约3至约30个氨基酸残基的寡肽，所述寡肽具有与细胞表面上的蛋白受体相互作用的氨基酸序列; 及其组合。 还提供了使表面活性剂聚合物和使用表面活性剂聚合物改变生物材料的表面性质的方法。

    Biodegradable coating with inhibitory properties for application to biocompatible materials
    10.
    发明授权
    Biodegradable coating with inhibitory properties for application to biocompatible materials 失效
    具有抑制性能的可生物降解涂料，适用于生物相容性材料

    公开(公告)号：US5788979A

    公开(公告)日：1998-08-04

    申请号：US798333

    申请日：1997-02-10

    Applicant: Eckhard Alt ,  Axel Stemberger

    Inventor： Eckhard Alt ,  Axel Stemberger

    IPC: A61F2/00 ,  A61F2/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/06 ,  A61L33/08 ,  A61L33/12

    CPC classification number: A61L31/16 ,  A61F2/062 ,  A61L31/10 ,  A61L31/148 ,  A61L33/0011 ,  A61L33/0047 ,  A61L33/066 ,  A61L33/068 ,  A61L33/08 ,  A61L33/124 ,  A61F2250/0067 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/608 ,  Y10S623/92 ,  Y10S623/924

    Abstract: A method is disclosed for coating a biomaterial to be placed in contact with a patient's blood flow to inhibit blood coagulation from adhering to the biomaterial that would otherwise result from such contact. A biodegradable material of liquid state compatible with the blood and tissue of the human body is prepared, and an anti-coagulant drug is incorporated into the liquid state of the biodegradable material to form a liquid coating material. The liquid coating material is adhesively applied to a surface of the biomaterial in a substantially continuous overlying layer having a formulation, pattern and thickness selected according to the period of time over which the coating material is to perform its anti-coagulant action. Thereafter the coating material is dried to a layer thickness less than about 100 microns for continuous disintegration thereof as a function of time when the layer is in contact with flowing blood. The method is utilized in an exemplary embodiment in which the biomaterial is a vascular stent.

    Abstract translation: 公开了一种用于涂覆待放置与患者血液流动接触的生物材料以抑制血液凝固附着于否则由此类接触引起的生物材料的方法。 制备与人体血液和组织相容的液体状态的可生物降解材料，将抗凝剂药物并入生物降解材料的液态，形成液体涂料。 液体涂料在基本上连续的上覆层中粘附到生物材料的表面上，其具有根据涂层材料要进行其抗凝结剂作用的时间段选择的配方，图案和厚度。 此后，当层与流动的血液接触时，将涂层材料干燥至厚度小于约100微米，以使其连续崩解，作为时间的函数。 在其中生物材料是血管支架的示例性实施例中使用该方法。

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