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公开(公告)号：US12087564B2
公开(公告)日：2024-09-10
申请号：US17557879
申请日：2021-12-21
发明人： Scott Grayson
IPC分类号： H01J49/00 , C07D319/06 , C07D493/22
CPC分类号： H01J49/0009 , C07D319/06 , C07D493/22 , H01J49/004 , Y10T436/10
摘要： Provided are synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative case and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures. The latter characteristic enables parallel preparation of higher molecular weight compounds displaying useful distributions of discrete molecular weights, thereby providing multi-point mass spectrometry calibration standards. Methods of making, tuning and using said calibrants are provided.
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公开(公告)号：US20240200074A1
公开(公告)日：2024-06-20
申请号：US18555477
申请日：2022-04-13
发明人： Eckhard ALT , Reza IZADPANAH
IPC分类号： C12N15/113 , A61K45/06 , A61P35/04
CPC分类号： C12N15/113 , A61K45/06 , A61P35/04 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： A method for preventing and treating micrometastasis in a patient with cancer, especially breast cancer or glioblastoma tumors, by silencing TRAF3IP2 before during or in connection with treatment as described herein.
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3.发明授权公开(公告)号：US12015378B2
公开(公告)日：2024-06-18
申请号：US17619185
申请日：2020-06-14
发明人： Matthew David Escarra , Luke Artzt , Yaping Ji , Daniel Codd , Matthew Barrios , Kazi M. Islam , David M. Bar-On , Jacqueline C. Failla , Claire C. Davis , Maxwell W. Woody
IPC分类号： H02S40/44 , F24S10/70 , F24S20/20 , F24S70/65 , F24S23/72 , F24S30/452 , H01L31/0304 , H01L31/0336 , H01L31/05 , H01L31/06
CPC分类号： H02S40/44 , F24S10/744 , F24S20/20 , F24S70/65 , F24S23/72 , F24S30/452 , H01L31/03046 , H01L31/0336 , H01L31/0512 , H01L31/06
摘要： A hybrid receiver for a concentrator photovoltaic-thermal power system combines a concentrator photovoltaic (CPV) module and a thermal module that converts concentrated sunlight into electrical energy and thermal heat. Heat transfer fluid flowing through a cooling block removes waste heat generated by photovoltaic cells in the CPV module. The heat transfer fluid then flows through a helical tube illuminated by sunlight that misses the CPV module. Only one fluid system is used to both remove the photovoltaic-cell waste heat and capture high-temperature thermal energy from sunlight. Fluid leaving the hybrid receiver can have a temperature greater than 200° C., and therefore may be used as a source of process heat for a variety of commercial and industrial applications. The hybrid receiver can maintain the photovoltaic cells at temperatures below 110° C. while achieving overall energy conversion efficiencies exceeding 80%.
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公开(公告)号：US11940384B2
公开(公告)日：2024-03-26
申请号：US17951721
申请日：2022-09-23
CPC分类号： G01N21/75 , B01J19/0006 , C08F20/56 , B01J2219/00186 , B01J2219/002 , B01J2219/00218 , B01J2219/00231 , C08F2400/02
摘要： Devices and methods for determining the cumulative distribution of a polymer property in a reactor without physical separation of reaction subcomponents. The device includes a means of measuring an instantaneous property of the polymers being produced in a reaction vessel a plurality of times during a polymerization reaction as well as a means of determining the corresponding change in polymer concentration in the reaction vessel between measurements of the instantaneous polymer property. The device also includes a means of computing a statistical distribution appropriate to the polymer characteristic and applying the statistical distribution to a recently measured instantaneous value of the polymer property so as to have an instantaneous distribution of the polymer property and a means of adding together the instantaneous distributions of the polymer property in order to obtain the cumulative distribution of the polymer property in the reactor.
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公开(公告)号：US11801332B2
公开(公告)日：2023-10-31
申请号：US15749948
申请日：2016-08-03
发明人： Noshir Pesika , Tushar Khosla
CPC分类号： A61L27/50 , A61F2/30771 , A61L27/18 , A61L27/56 , A61L29/06 , A61L29/14 , A61L29/146 , G02B1/043 , G02C7/04 , A61F2002/30354 , A61F2002/30673 , A61F2002/30807 , A61L2400/10
摘要： A medical device for cooperating with a body surface of a patient includes an elastically deformable substrate having a first surface, a second surface, and a plurality of pores extending from the first surface towards the second surface to define a plurality of spaced-apart projections. A lubricant is provided in the pores. Applying a compressive force to the substrate with the body surface elastically deforms the projections to displace the lubricant out of the pores and provide hydrodynamic lubrication between the medical device and the body surface.
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公开(公告)号：US20230310540A1
公开(公告)日：2023-10-05
申请号：US17796950
申请日：2021-02-12
CPC分类号： A61K38/12 , C07K7/64 , A61K45/06 , A01P1/00 , A01N63/50 , A61K9/0014 , A61P31/04 , A61P17/02
摘要： Described herein are antimicrobial peptides, polynucleotides encoding the peptides, and compositions containing the peptides. Furthermore, described herein are methods for using the peptides, polynucleotides, and compositions for research and therapy.
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7.发明公开公开(公告)号：US20230250229A1
公开(公告)日：2023-08-10
申请号：US18297123
申请日：2023-04-07
发明人： Scott M. GRAYSON
IPC分类号： C08G65/337 , C08F20/14 , C08F20/18 , C08F20/56 , H01J49/00 , C08G69/48 , C08F12/22 , C08G83/00
CPC分类号： C08G65/337 , C08F20/14 , C08F20/18 , C08F20/56 , H01J49/0009 , C08G69/48 , C08F12/22 , C08G83/006
摘要： The present invention discloses novel calibrants containing between 1 and 5 iodine atoms and methods of making them using linear polymers, hyperbranched polymers, and biological polymers (including but not limited to proteins and peptides.) Methods of using the calibrants are also disclosed, such as mass spectrometry. The novel calibrants disclosed herein have a more cost- and time-efficient synthesis than other calibrants.
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公开(公告)号：US20230220010A1
公开(公告)日：2023-07-13
申请号：US17916295
申请日：2021-03-31
IPC分类号： C07K14/00 , C07K7/08 , C07K7/06 , A61K39/39 , A61P31/14 , A61P31/16 , A61K39/215 , A61P31/22
CPC分类号： C07K14/001 , C07K7/08 , C07K7/06 , A61K39/39 , A61P31/14 , A61P31/16 , A61K39/215 , A61P31/22 , A61K2039/545
摘要： Described herein are antiviral peptides, polynucleotides encoding the peptides, and compositions containing the peptides. Furthermore, described herein are methods for using the peptides, polynucleotides, and compositions for treating or inhibiting a viral infection or one or more symptoms of a viral infection.
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9.发明申请公开(公告)号：US20220311378A1
公开(公告)日：2022-09-29
申请号：US17619185
申请日：2020-06-14
发明人： Matthew David ESCARRA , Luke ARTZT , Yaping JI , Daniel CODD , Matthew BARRIOS , Kazi M. ISLAM , David M. BAR-OR , Jacqueline C. FAILLA , Claire C. DAVIS , Maxwell W. WOODY
摘要： A hybrid receiver for a concentrator photovoltaic-thermal power system combines a concentrator photovoltaic (CPV) module and a thermal module that converts concentrated sunlight into electrical energy and thermal heat. Heat transfer fluid flowing through a cooling block removes waste heat generated by photovoltaic cells in the CPV module. The heat transfer fluid then flows through a helical tube illuminated by sunlight that misses the CPV module. Only one fluid system is used to both remove the photovoltaic-cell waste heat and capture high-temperature thermal energy from sunlight. Fluid leaving the hybrid receiver can have a temperature greater than 200° C., and therefore may be used as a source of process heat for a variety of commercial and industrial applications. The hybrid receiver can maintain the photovoltaic cells at temperatures below 110° C. while achieving overall energy conversion efficiencies exceeding 80%.
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公开(公告)号：US20220257791A1
公开(公告)日：2022-08-18
申请号：US17673063
申请日：2022-02-16
申请人： The Administrators of the Tulane Educational Fund , Board of Supervisors of Louisiana State Univeristy and Agricultural and Mechanical College
发明人： Marzhana Omarova , Vijay T. John , Donghui Zhang
摘要： The disclosure relates to multilayered vesicles, methods for forming multilayered vesicles, and drug delivery complexes including multilayered vesicles. The multilayered vesicles can be formed by adding hydrophobe containing polypeptoid (HCP)-lipid complexes to unilamellar vesicles such as liposomes in an amount effective to form multilayered vesicles. The HCP-lipid complexes can be produced by mixing a hydrophobe containing polypeptoid (HCP) with a first set of unilamellar vesicles. The unilamellar vesicles and/or drug delivery complexes can include various cargoes for delivery, such as water-soluble cargoes, hydrophobic cargoes, etc.
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