公开(公告)号：US12036126B2

公开(公告)日：2024-07-16

申请号：US17967503

申请日：2022-10-17

申请人： NANOHIVE MEDICAL LLC

发明人： Christopher Laine ,  Ian Helmar ,  Lucas Diehl ,  Jason Tinley ,  Kevin D. Chappuis ,  John F. Sullivan

IPC分类号： A61F2/44 ,  A61C8/00 ,  A61C13/00 ,  A61F2/28 ,  A61F2/30 ,  A61L27/50 ,  A61L27/56 ,  B33Y80/00 ,  A61F2/00 ,  B29C64/165

CPC分类号： A61F2/3094 ,  A61C8/0013 ,  A61C13/0019 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30771 ,  A61F2/30907 ,  A61F2/30942 ,  A61F2/44 ,  A61F2/4455 ,  A61L27/505 ,  A61L27/56 ,  B33Y80/00 ,  A61F2002/0081 ,  A61F2002/2835 ,  A61F2002/30006 ,  A61F2002/30014 ,  A61F2002/30069 ,  A61F2002/30113 ,  A61F2002/3014 ,  A61F2002/30141 ,  A61F2002/30143 ,  A61F2002/30146 ,  A61F2002/30148 ,  A61F2002/30151 ,  A61F2002/30154 ,  A61F2002/30156 ,  A61F2002/30263 ,  A61F2002/30273 ,  A61F2002/30677 ,  A61F2002/30766 ,  A61F2/30767 ,  A61F2002/30914 ,  A61F2002/30919 ,  A61F2002/3092 ,  A61F2002/3093 ,  A61F2002/30943 ,  A61F2210/0057 ,  A61F2240/001 ,  A61F2310/00023 ,  A61L2430/02 ,  B29C64/165

摘要： The three-dimensional lattice structures disclosed herein have applications including use in medical implants. Some examples of the lattice structure are structural in that they can be used to provide structural support or mechanical spacing. In some examples, the lattice can be configured as a scaffold to support bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. The lattice structures are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

公开(公告)号：US11998251B2

公开(公告)日：2024-06-04

申请号：US17670279

申请日：2022-02-11

申请人： P Tech, LLC

发明人： Peter M. Bonutti ,  Matthew J. Cremens ,  Justin E. Beyers

IPC分类号： A61B17/80 ,  A61B17/04 ,  A61B17/68 ,  A61B17/70 ,  A61B17/72 ,  A61B17/82 ,  A61B17/86 ,  A61B17/88 ,  A61F2/40 ,  A61B17/00 ,  A61B17/11 ,  A61B17/17 ,  A61B17/32 ,  A61F2/28 ,  A61F2/30 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  A61F2/42 ,  A61F2/44 ,  A61F2/46 ,  A61F2/82 ,  G06F21/10

CPC分类号： A61B17/7233 ,  A61B17/0401 ,  A61B17/686 ,  A61B17/7032 ,  A61B17/7058 ,  A61B17/7059 ,  A61B17/7062 ,  A61B17/72 ,  A61B17/725 ,  A61B17/80 ,  A61B17/8033 ,  A61B17/82 ,  A61B17/866 ,  A61B17/88 ,  A61B17/8863 ,  A61F2/4081 ,  A61B2017/00004 ,  A61B2017/00504 ,  A61B2017/0409 ,  A61B2017/044 ,  A61B17/11 ,  A61B17/1128 ,  A61B17/1146 ,  A61B17/1721 ,  A61B17/1742 ,  A61B17/320068 ,  A61B17/8038 ,  A61B2017/8655 ,  A61B17/8685 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30133 ,  A61F2002/30451 ,  A61F2002/30604 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2/30756 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30878 ,  A61F2002/30892 ,  A61F2002/30894 ,  A61F2002/30971 ,  A61F2002/30973 ,  A61F2/32 ,  A61F2002/3401 ,  A61F2002/3403 ,  A61F2/3603 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4202 ,  A61F2002/444 ,  A61F2/4455 ,  A61F2/468 ,  A61F2002/828 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2220/0058 ,  A61F2230/0015 ,  A61F2250/0068 ,  A61F2310/00011 ,  A61F2310/00365 ,  A61F2310/00383 ,  G06F21/1077 ,  G06F2221/2137

摘要： The present invention provides a method for stabilizing a fractured bone. The method includes positioning an elongate rod in the medullary canal of the fractured bone and forming a passageway through the cortex of the bone. The passageway extends from the exterior surface of the bone to the medullary canal of the bone. The method also includes creating a bonding region on the elongate rod. The bonding region is generally aligned with the passageway of the cortex. Furthermore, the method includes positioning a fastener in the passageway of the cortex and on the bonding region of the elongate rod and thermally bonding the fastener to the bonding region of the elongate rod while the fastener is positioned in the passageway of the cortex.

公开(公告)号：US11913870B2

公开(公告)日：2024-02-27

申请号：US17585306

申请日：2022-01-26

申请人： Lumacyte, Inc.

发明人： Sean Hart ,  Colin Hebert

IPC分类号： G01N15/14 ,  B01L3/00 ,  G01N15/00 ,  G01N15/10 ,  A61F2/30

CPC分类号： G01N15/1484 ,  B01L3/502761 ,  G01N15/00 ,  A61F2002/30677 ,  B01L2200/0652 ,  G01N2015/1006

摘要： Provided are methods and devices for assessing biological particles for use in cell immunotherapy. By utilizing a microfluidic chip device together with optical force measurement and cell imaging, the methods enable comprehensive assessment and characterization of biological particles with regard to morphology, motility, binding affinities, and susceptibility to external forces, including but not limited to, chemical, biochemical, biological, physical and temperature influences. The methods enable the selection and production of biological particles, such as engineered T-cells, for use in immunotherapy and biomanufacturing.

公开(公告)号：US11833052B2

公开(公告)日：2023-12-05

申请号：US16253698

申请日：2019-01-22

申请人： BIEDERMANN TECHNOLOGIES GMBH & CO. KG

发明人： Ronald W. Lindsey ,  Zbigniew Gugala ,  Loren L. Latta

IPC分类号： A61F2/30 ,  A61F2/38 ,  A61F2/40 ,  A61F2/44 ,  A61B17/68 ,  A61F2/28 ,  A61B17/72 ,  A61B17/74 ,  A61B17/80 ,  A61B17/86 ,  A61F2/32 ,  A61F2/42

CPC分类号： A61F2/30907 ,  A61B17/68 ,  A61B17/72 ,  A61B17/7233 ,  A61B17/7291 ,  A61B17/742 ,  A61B17/80 ,  A61B17/866 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30771 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61F2002/2835 ,  A61F2002/3085 ,  A61F2002/3092 ,  A61F2002/30235 ,  A61F2002/30677 ,  A61F2002/30784 ,  A61F2310/00179 ,  A61F2310/00353 ,  A61F2310/00359 ,  A61F2310/00407 ,  A61F2310/00413 ,  A61F2310/00592 ,  A61F2310/00796

摘要： The present invention relates to orthopaedic implants having a fenestrated hollow shell and a biologic core. These design features provide an improved interface between the implant and the surrounding tissue, aiding fixation, and provide a vehicle for applying new bone healing and enhancing modalities, such as gene therapy, tissue engineering, and growth factors.

公开(公告)号：US11806240B2

公开(公告)日：2023-11-07

申请号：US16518281

申请日：2019-07-22

申请人： NANOHIVE MEDICAL LLC

发明人： Christopher Laine ,  Ian Helmar ,  Lucas Diehl ,  Jason Tinley ,  Kevin D. Chappuis ,  John F. Sullivan

IPC分类号： A61F2/28 ,  A61F2/30 ,  A61C13/00 ,  A61C8/00 ,  B33Y80/00 ,  A61F2/44 ,  A61L27/50 ,  A61L27/56 ,  B29C64/165 ,  A61F2/00

CPC分类号： A61F2/3094 ,  A61C8/0013 ,  A61C13/0019 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30771 ,  A61F2/30907 ,  A61F2/30942 ,  A61F2/44 ,  A61F2/4455 ,  A61L27/505 ,  A61L27/56 ,  B33Y80/00 ,  A61F2/30767 ,  A61F2002/0081 ,  A61F2002/2835 ,  A61F2002/30006 ,  A61F2002/30014 ,  A61F2002/3014 ,  A61F2002/30069 ,  A61F2002/3092 ,  A61F2002/3093 ,  A61F2002/30113 ,  A61F2002/30141 ,  A61F2002/30143 ,  A61F2002/30146 ,  A61F2002/30148 ,  A61F2002/30151 ,  A61F2002/30154 ,  A61F2002/30156 ,  A61F2002/30263 ,  A61F2002/30273 ,  A61F2002/30677 ,  A61F2002/30766 ,  A61F2002/30914 ,  A61F2002/30919 ,  A61F2002/30943 ,  A61F2210/0057 ,  A61F2240/001 ,  A61F2310/00023 ,  A61L2430/02 ,  B29C64/165

摘要： The three-dimensional lattice structures disclosed herein have applications including use in medical implants. Some examples of the lattice structure are structural in that they can be used to provide structural support or mechanical spacing. In some examples, the lattice can be configured as a scaffold to support bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. The lattice structures are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

公开(公告)号：US20230338151A1

公开(公告)日：2023-10-26

申请号：US18303291

申请日：2023-04-19

申请人： Heraeus Medical GmbH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： A61F2/30

CPC分类号： A61F2/30734 ,  A61F2002/30215 ,  A61F2002/30217 ,  A61F2002/30736 ,  A61F2002/3069 ,  A61F2002/30822 ,  A61F2002/30828 ,  A61F2002/30561 ,  A61F2002/30677

摘要： The invention relates to an augmentation device comprising an annular cone surrounding a channel which extends through the cone from a proximal cone end to a distal cone end of said cone. The invention furthermore relates to a method for adapting a cone size of such an augmentation device.

公开(公告)号：US11660379B2

公开(公告)日：2023-05-30

申请号：US17701421

申请日：2022-03-22

申请人： Cardiac Pacemakers, Inc.

发明人： David R. Wulfman ,  Danielle Frankson ,  Adeniyi O. Aremu ,  Angelo Fruci ,  Gregory J. Sherwood ,  Mary M. Byron ,  Joseph T. Delaney, Jr. ,  Adam McGraw

IPC分类号： A61L24/00 ,  B05D3/00 ,  A61L29/16 ,  A61L31/06 ,  A61L31/04 ,  A61L31/10 ,  B05D3/06 ,  B05D3/10 ,  A61F2/30 ,  A61L27/28 ,  B05D3/02

CPC分类号： A61L29/16 ,  A61F2/30767 ,  A61L27/28 ,  A61L31/046 ,  A61L31/06 ,  A61L31/10 ,  B05D3/007 ,  B05D3/061 ,  B05D3/108 ,  A61F2002/30677 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2420/02 ,  A61M2207/00 ,  B05D3/0254 ,  B05D2518/00 ,  A61L31/10 ,  C08L71/02 ,  A61L31/06 ,  C08L75/04 ,  A61L31/046 ,  C08L27/12

摘要： An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

公开(公告)号：US11642229B2

公开(公告)日：2023-05-09

申请号：US15628875

申请日：2017-06-21

申请人： DePuy Synthes Products, Inc.

发明人： Fausto Olmos ,  Brad S. Culbert ,  Bob Flower

IPC分类号： A61F2/44 ,  A61F2/46 ,  A01H5/12 ,  A24B13/00 ,  A24B15/18 ,  A24D1/00 ,  A24F47/00 ,  A61B17/02 ,  A61F2/30

CPC分类号： A61F2/447 ,  A01H5/12 ,  A24B13/00 ,  A24B15/18 ,  A24D1/00 ,  A24F47/00 ,  A61B17/025 ,  A61F2/30771 ,  A61F2/4455 ,  A61F2/46 ,  A61F2/4611 ,  A61F2/4657 ,  A61B2017/0256 ,  A61F2002/3055 ,  A61F2002/30062 ,  A61F2002/30092 ,  A61F2002/30387 ,  A61F2002/30507 ,  A61F2002/30522 ,  A61F2002/30523 ,  A61F2002/30579 ,  A61F2002/30593 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30892 ,  A61F2002/448 ,  A61F2002/4629 ,  A61F2002/4659 ,  A61F2002/4661 ,  A61F2002/4667 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2310/00017 ,  A61F2310/00023 ,  Y02E50/10

摘要： An adjustable spinal fusion intervertebral implant is provided that can comprise upper and lower body portions that can each have proximal and distal wedge surf aces disposed at proximal and distal ends thereof. An actuator shaft disposed intermediate the upper and lower body portions can be actuated to cause proximal and distal protrusions to converge towards each other and contact the respective ones of the proximal and distal wedge surfaces. Such contact can thereby transfer the longitudinal movement of the proximal and distal protrusions against the proximal and distal wedge surfaces to cause the separation of the upper and lower body portions, thereby expanding the intervertebral implant. The upper and lower body portions can have side portions that help facilitate linear translational movement of the upper body portion relative to the lower body portion.

公开(公告)号：US20190216612A1

公开(公告)日：2019-07-18

申请号：US16366381

申请日：2019-03-27

申请人： Benvenue Medical, Inc.

发明人： Laurent Schaller ,  Timothy McGrath ,  Ryan Connolly ,  David Needleman ,  Steven Golden ,  John Ashley ,  James Lee ,  Jeffrey Emery ,  J. Brook Burley

IPC分类号： A61F2/44 ,  A61F2/46 ,  A61B17/88 ,  A61B17/70

CPC分类号： A61F2/4425 ,  A61B17/7094 ,  A61B17/8852 ,  A61B2017/0256 ,  A61F2/44 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/3008 ,  A61F2002/30092 ,  A61F2002/30153 ,  A61F2002/30235 ,  A61F2002/30263 ,  A61F2002/30289 ,  A61F2002/30462 ,  A61F2002/3052 ,  A61F2002/30579 ,  A61F2002/30594 ,  A61F2002/30598 ,  A61F2002/30601 ,  A61F2002/30677 ,  A61F2002/30772 ,  A61F2002/448 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2002/4677 ,  A61F2002/4683 ,  A61F2002/4688 ,  A61F2210/0014 ,  A61F2210/0071 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2230/0019 ,  A61F2230/0069 ,  A61F2230/0084 ,  A61F2230/0091 ,  A61F2310/00293 ,  B33Y80/00 ,  H05K999/99

摘要： Method and apparatus are disclosed for distracting tissue and particularly spinal tissue. The device and method may include insertion of at least one elongated member and an augmenting member to form a structure between the tissues to be distraction, such that a dimensional aspect of the structure is augmented upon movement of the augmenting structure.

公开(公告)号：US20190000630A1

公开(公告)日：2019-01-03

申请号：US16066412

申请日：2016-12-23

申请人： TECRES S.p.A.

发明人： Giovanni FACCIOLI ,  Renzo SOFFIATTI

IPC分类号： A61F2/30 ,  A61F2/36 ,  A61F2/38

CPC分类号： A61F2/30724 ,  A61F2/30965 ,  A61F2/36 ,  A61F2/3859 ,  A61F2002/30672 ,  A61F2002/30677 ,  A61F2002/368 ,  A61F2310/00353

摘要： Core for a spacer, including a main body that comprises a plurality of through openings, adapted to be secured in a corresponding residual bone bed of a previous implant; the main body being adapted to be covered with a layer (S) of a coating material or a material including acrylic bone cement added or that can be added with one or a plurality of pharmaceutical products or active and/or therapeutic substances.