公开(公告)号：US11925731B2

公开(公告)日：2024-03-12

申请号：US17896525

申请日：2022-08-26

申请人： Texas Medical Center

发明人： Timothy J. Keane, Jr. ,  Peter Alexander Smith ,  Stephen G. Ramon

IPC分类号： A61L31/14 ,  A61L31/00 ,  A61L31/04

CPC分类号： A61L31/145 ,  A61L31/005 ,  A61L31/041 ,  A61L2400/06

摘要： Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 μm. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.