公开(公告)号：US20240218164A1

公开(公告)日：2024-07-04

申请号：US18558293

申请日：2022-05-13

申请人： YOUREH CO., LTD.

发明人： Hyang Mae UM ,  Eui Jin HWANG

IPC分类号： C08L5/08 ,  A61L15/22 ,  A61L15/42 ,  A61L15/46 ,  A61L15/64 ,  C08L5/04

CPC分类号： C08L5/08 ,  A61L15/225 ,  A61L15/42 ,  A61L15/46 ,  A61L15/64 ,  C08L5/04 ,  A61L2300/404 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2205/025

摘要： Provided are a method for preparing a composition having a form and use applicable in various fields from a mixed aqueous solution obtained by dissolving an anionic polymer and a cationic polymer in an aqueous solution without any precipitation/suspension phenomenon, comprising adding an electrolyte for a mixed aqueous solution comprising an anionic polymer and a cationic polymer in an amount that an ionic strength (I) of the electrolyte in the mixed aqueous solution satisfies a condition of: (1) (16.5×(number of moles of polymer used in smaller amount among the anionic polymer and the cationic polymer)×(NIG)2)≤ionic strength (I)≤(30×number of moles of the anionic polymer); or (2) 0.001

公开(公告)号：US20230323577A1

公开(公告)日：2023-10-12

申请号：US18056781

申请日：2022-11-18

申请人： NFS IP Holdings, LLC

发明人： Jed JOHNSON

IPC分类号： D04H1/728 ,  A61L27/58 ,  A61L27/38 ,  A61L15/40 ,  A61L15/64 ,  D04H1/4266 ,  D04H1/435 ,  A61L27/48 ,  A61L27/60

CPC分类号： D04H1/728 ,  A61L27/58 ,  A61L27/38 ,  A61L15/40 ,  A61L15/64 ,  D04H1/4266 ,  D04H1/435 ,  A61L27/48 ,  A61L27/60

摘要： A scaffold may comprise a first polymeric electrospun fiber comprising a first material having a first degradation rate, and a second polymeric electrospun fiber comprising a second material having a second degradation rate different from the first degradation rate. The first degradation rate may substantially correspond to a cell infiltration rate, and the second degradation rate may be slower than the first degradation rate. Such a scaffold may be manufactured by electrospinning a first polymer fiber having a first degradation rate by ejecting a first polymer solution from a first polymer injection system onto a mandrel, and electrospinning a second polymer fiber having a second degradation rate different from the first degradation rate by ejecting a second polymer solution from a second polymer injection system onto a mandrel. Wound healing may be improved by applying such a scaffold to a portion of a wound.

公开(公告)号：US20180303941A1

公开(公告)日：2018-10-25

申请号：US15529288

申请日：2015-11-25

申请人： Northwestern University

发明人： Guillermo A. AMEER ,  Michele JEN

IPC分类号： A61K47/32 ,  A61K38/50 ,  A61P17/02 ,  A61K9/00 ,  A61K47/10 ,  A61K47/34 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L15/62 ,  A61K48/00

CPC分类号： A61K47/32 ,  A61K9/0014 ,  A61K38/50 ,  A61K47/10 ,  A61K47/34 ,  A61K48/0016 ,  A61K48/005 ,  A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2430/34 ,  A61P17/02 ,  C12N2800/95 ,  C12Y305/01

摘要： Compositions and methods are provided for improved wound healing. In particular, provided herein are compositions and methods for the direct delivery of Sirtuin-1 (Sirt1) or vectors encoding Sirt1 to the wounds (e.g., of diabetic patients). In some embodiments, provided herein are therapeutic devices comprising: (a) a vector encoding Sirtuin-1 (Sirt 1); and (b) a hydrogel carrier. In some embodiments, the vector comprises a viral vector comprising a polynucleotide sequence encoding Sirt 1. In some embodiments, the vector comprises a non-viral vector comprising a polynucleotide sequence encoding Sirt1.

公开(公告)号：US20180021477A1

公开(公告)日：2018-01-25

申请号：US15548714

申请日：2016-02-25

申请人： DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD.

发明人： Yasuyuki ISONO ,  Yasuharu NOISHIKI

IPC分类号： A61L27/34 ,  A61L27/58 ,  A61L27/50 ,  A61L27/56

CPC分类号： A61L27/34 ,  A61L15/64 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/12 ,  A61L31/148 ,  A61L2300/236 ,  A61L2300/424 ,  A61P41/00 ,  C08L1/26 ,  C08L5/04 ,  C08L5/08

摘要： There is provided a medical material that retains the properties which are inherent in a polyanionic polysaccharide being a raw material, that has a high level of safety because there is no need to use a chemical crosslinking agent during production, and that has a moderate strength with which a suture and the like can be conducted. The medical material is provided with a reinforcement material and a film section penetrating at least a portion of the reinforcement material to be integrated with the reinforcement material. In the medical material, the film section is formed by water-insolubilizing a film precursor section made of a raw material containing a water-soluble salt of a first polyanionic polysaccharide with a treatment liquid containing a first acid anhydride, and the reinforcement material is nonwoven fabric or woven fabric containing a biodegradable/absorbent polymer material, or a sponge-like carrier or a felt-like carrier formed by water-insolubilizing a raw material-shaped body made of a raw material containing a water-soluble salt of a second polyanionic polysaccharide with a treatment liquid containing a second acid anhydride.

公开(公告)号：US09782511B2

公开(公告)日：2017-10-10

申请号：US14996483

申请日：2016-01-15

申请人： BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH ,  CARL FREUDENBERG KG

发明人： Frank Plöger ,  Denis Reibel ,  Dirk Grafahrend ,  Daniel Neumüller

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61L15/32 ,  A61L15/64 ,  A61F13/00 ,  A61L15/18 ,  A61L15/22 ,  A61L15/42 ,  A61L15/44 ,  A61L15/62 ,  D04H1/30 ,  D04H1/4266

CPC分类号： A61L15/32 ,  A61F13/00 ,  A61K38/1875 ,  A61L15/18 ,  A61L15/22 ,  A61L15/325 ,  A61L15/42 ,  A61L15/425 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/604 ,  D04H1/30 ,  D04H1/4266

摘要： The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. Furthermore, the invention provides wound dressings, pads or implants comprising the novel non-woven fabrics.

公开(公告)号：US20170020996A1

公开(公告)日：2017-01-26

申请号：US14267395

申请日：2014-05-01

申请人： JAMES A. LIVINGSTON

发明人： JAMES A. LIVINGSTON

IPC分类号： A61K38/48 ,  A61L15/64 ,  A61K9/00 ,  A61K9/06 ,  A61K31/17 ,  A61L15/44 ,  A61L15/38

CPC分类号： A61K38/4873 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/7007 ,  A61K31/17 ,  A61K38/45 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/488 ,  A61K38/4886 ,  A61L15/38 ,  A61L15/44 ,  A61L15/64 ,  A61L2300/254 ,  B42D15/045 ,  C12Y304/21004 ,  C12Y304/21064 ,  C12Y304/22002 ,  C12Y304/22003 ,  C12Y304/22032 ,  C12Y304/22033 ,  A61K2300/00

摘要： Compositions and methods are provided to destroy internal cancerous lesions selectively by the administration of a combination of a debridement protease enzyme and a denaturant of cell structural proteins and or cell adhesion proteins.

摘要翻译： 提供组合物和方法通过施用清创蛋白酶和细胞结构蛋白的变性剂和/或细胞粘附蛋白的组合来选择性地破坏内部癌性病变。

公开(公告)号：US09456860B2

公开(公告)日：2016-10-04

申请号：US12347791

申请日：2008-12-31

申请人： Archel Ambrosio

发明人： Archel Ambrosio

IPC分类号： A61K47/36 ,  A61K38/18 ,  A61M1/00 ,  A61K47/02 ,  A61K35/12 ,  A61K47/42 ,  A61K47/32 ,  A61B17/88 ,  A61F13/00 ,  A61L15/20 ,  A61L15/42 ,  A61L15/54 ,  A61L15/60 ,  A61L15/64 ,  A61L26/00 ,  A61F13/40 ,  A61M37/00 ,  A61B17/80 ,  A61F2/30 ,  A61F2/36

CPC分类号： A61B17/88 ,  A61B17/80 ,  A61F2/30767 ,  A61F2/36 ,  A61F2/3662 ,  A61F13/00017 ,  A61F13/00063 ,  A61F13/00068 ,  A61F2002/30677 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30968 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/368 ,  A61F2002/3694 ,  A61F2013/00157 ,  A61F2013/00174 ,  A61F2013/00221 ,  A61F2013/00255 ,  A61F2013/00519 ,  A61F2013/0054 ,  A61F2013/0074 ,  A61F2013/00863 ,  A61F2013/00927 ,  A61F2310/00395 ,  A61F2310/00592 ,  A61F2310/00928 ,  A61L15/20 ,  A61L15/425 ,  A61L15/54 ,  A61L15/60 ,  A61L15/64 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/0085 ,  A61L26/009 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/64 ,  A61M1/0088 ,  A61M35/006 ,  A61M37/00

摘要： Provided is a flowable bioresorbable tissue dressing comprising a gas-forming porogen and a gel or gel-forming solution. Also provided is kits for preparing the above-described tissue dressing. Further provided are methods of treating a tissue site of a mammal with the above dressing. Also provided is a reduced pressure delivery system for applying a reduced pressure tissue treatment to a tissue site.

摘要翻译： 提供了一种可流动的生物可再吸收组织敷料，其包含气体成孔致孔剂和凝胶或凝胶形成溶液。 还提供了用于制备上述组织敷料的试剂盒。 还提供了用上述敷料处理哺乳动物的组织部位的方法。 还提供了一种用于对组织部位施加减压组织处理的减压递送系统。

公开(公告)号：US20160213806A1

公开(公告)日：2016-07-28

申请号：US15088438

申请日：2016-04-01

申请人： STB, Ltd.

发明人： Martin MacPhee ,  Dawson Beall

IPC分类号： A61L15/44 ,  A61L15/22 ,  A61L15/32 ,  A61L15/58 ,  A61L15/64 ,  A61L15/38

CPC分类号： A61L15/64 ,  A61F13/00012 ,  A61F13/00017 ,  A61F13/00021 ,  A61F13/00029 ,  A61F13/00034 ,  A61F13/00063 ,  A61F13/00068 ,  A61F13/00991 ,  A61F13/02 ,  A61F13/0226 ,  A61F13/0246 ,  A61F2013/00106 ,  A61F2013/00174 ,  A61F2013/00472 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/0091 ,  A61F2013/00931 ,  A61K38/363 ,  A61K38/4833 ,  A61L15/18 ,  A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/32 ,  A61L15/325 ,  A61L15/38 ,  A61L15/44 ,  A61L15/58 ,  A61L26/0042 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/10 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/418 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2400/04 ,  C12Y304/21005 ,  C08L89/00

摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue.

公开(公告)号：US20160184493A1

公开(公告)日：2016-06-30

申请号：US15064674

申请日：2016-03-09

申请人： Poly-Med, Inc.

发明人： Shalaby W. Shalaby

IPC分类号： A61L31/12 ,  A61K31/7135 ,  A61K9/00 ,  A61L31/16 ,  A61L31/14 ,  A61K31/375 ,  A61K31/4164

CPC分类号： A61L31/129 ,  A61F2250/0031 ,  A61K9/0002 ,  A61K9/0024 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/0046 ,  A61K9/146 ,  A61K31/375 ,  A61K31/4164 ,  A61K31/7135 ,  A61L15/44 ,  A61L15/64 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/256 ,  A61L2300/404 ,  A61L2300/408 ,  A61L2300/43 ,  A61L2300/602

摘要： This invention describes a partially absorbable, fiber-reinforced composite in the form of a ring, or a suture-like thread, with modified terminals for use as a controlled delivery system of at least one bioactive agent, wherein said composite comprising an absorbable fiber construct capable of providing time-dependent mechanical properties of a biostable elastomeric matrix containing an absorbable microparticulate ion-exchanger to modulate the release of the bioactive agent(s) for a desired period(s) of time at a specific biological site; this can be a vaginal canal, peritoneal cavity, scrotum, prostate gland, an ear loop or subcutaneous tissue. Such drug delivery systems can be used for the local administration of at least one bioactive agent, including those used as contraceptive, antimicrobial, anti-inflammatory and/or antiviral agents as well as for cancer treatment.

公开(公告)号：US20160177026A1

公开(公告)日：2016-06-23

申请号：US14975303

申请日：2015-12-18

申请人： Poly-Med, Inc.

发明人： Kenneth David Gray, JR. ,  Michael Aaron Vaughn

IPC分类号： C08G63/64 ,  C08G63/91 ,  C08G63/85 ,  A61L15/64 ,  A61L15/26

CPC分类号： C08G63/64 ,  A61L15/26 ,  A61L15/64 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/606 ,  C08G63/85 ,  C08G63/91 ,  C08L67/04

摘要： The present invention relates to absorbable block copolymers with improved characteristics including thermal stability, molecular weight consistency, inherent viscosity retention following melt extrusion, and fibers made from the polymers exhibit increased strength.

摘要翻译： 本发明涉及具有改进特性的可吸收嵌段共聚物，包括热稳定性，分子量一致性，熔融挤出后的固有粘度保留性，以及由聚合物制成的纤维表现出增强的强度。