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公开(公告)号：US20230277469A1
公开(公告)日：2023-09-07
申请号：US18315618
申请日：2023-05-11
发明人： Christian Schneider
CPC分类号： A61K9/5026 , A61K49/04 , A61K38/47 , C12Y304/22032 , A61K9/5073 , A61K38/39 , A61K9/5031 , A61K9/5089 , C12Y304/22033
摘要： An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The membrane polymer matrix contains a hydrophobic polymer in combination with a hydrophilic compound, and the weight ratio of the hydrophobic polymer to the hydrophilic compound within the membrane polymer matrix ranges from about 0.25 to about 200.
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公开(公告)号：US11690806B2
公开(公告)日：2023-07-04
申请号：US16416328
申请日：2019-05-20
发明人： Christian Schneider
CPC分类号： A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K9/5089 , A61K38/39 , A61K38/47 , A61K49/04 , C12Y304/22032 , C12Y304/22033
摘要： An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The membrane polymer matrix contains a hydrophobic polymer in combination with a hydrophilic compound, and the weight ratio of the hydrophobic polymer to the hydrophilic compound within the membrane polymer matrix ranges from about 0.25 to about 200.
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3.发明申请FIBRINOLYTIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF PHLEBOTHROMBOTIC STATES 审中-公开用于预防和治疗嗜铬细胞的纤维蛋白组合物公开(公告)号：US20150297685A1
公开(公告)日：2015-10-22
申请号：US14646450
申请日：2013-11-06
发明人： Francesco Di Pierro
IPC分类号： A61K38/48
CPC分类号： A61K38/4873 , A61K38/482 , C12Y304/21062 , C12Y304/22032
摘要： Disclosed are compositions comprising bromelain and nattokinase, including as the only active ingredients. The composition may be administered orally, and may be in the form of bi-layer tablets. Methods of treating thrombophlebitis are also disclosed.
摘要翻译： 公开了包含菠萝蛋白酶和纳豆激酶的组合物，包括作为唯一活性成分。 组合物可以口服给药，并且可以是双层片剂的形式。 还公开了治疗血栓性静脉炎的方法。
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公开(公告)号：US08754045B2
公开(公告)日：2014-06-17
申请号：US11803304
申请日：2007-05-14
申请人： James A. Livingston
发明人： James A. Livingston
CPC分类号： A61K38/4873 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/7007 , A61K31/17 , A61K38/45 , A61K38/482 , A61K38/4826 , A61K38/488 , A61K38/4886 , A61L15/38 , A61L15/44 , A61L15/64 , A61L2300/254 , B42D15/045 , C12Y304/21004 , C12Y304/21064 , C12Y304/22002 , C12Y304/22003 , C12Y304/22032 , C12Y304/22033 , A61K2300/00
摘要： Compositions and methods are provided to destroy internal cancerous lesions selectively by the administration of a combination of a debridement protease enzyme and a denaturant of cell structural proteins and or cell adhesion proteins.
摘要翻译： 提供组合物和方法通过施用清创蛋白酶和细胞结构蛋白的变性剂和/或细胞粘附蛋白的组合来选择性地破坏内部癌性病变。
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公开(公告)号：US20080044459A1
公开(公告)日：2008-02-21
申请号：US11803304
申请日：2007-05-14
申请人： James Livingston
发明人： James Livingston
CPC分类号： A61K38/4873 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/7007 , A61K31/17 , A61K38/45 , A61K38/482 , A61K38/4826 , A61K38/488 , A61K38/4886 , A61L15/38 , A61L15/44 , A61L15/64 , A61L2300/254 , B42D15/045 , C12Y304/21004 , C12Y304/21064 , C12Y304/22002 , C12Y304/22003 , C12Y304/22032 , C12Y304/22033 , A61K2300/00
摘要： Compositions and methods are provided to destroy internal cancerous lesions selectively by the administration of a combination of a debridement protease enzyme and a denaturant of cell structural proteins and or cell adhesion proteins.
摘要翻译： 提供组合物和方法通过施用清创蛋白酶和细胞结构蛋白的变性剂和/或细胞粘附蛋白的组合来选择性地破坏内部癌性病变。
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公开(公告)号：US20230414728A1
公开(公告)日：2023-12-28
申请号：US18249097
申请日：2021-10-18
申请人： MEDIWOUND LTD.
发明人： Lior ROSENBERG , Dafna GEBLINGER , Eilon ASCULAI
IPC分类号： A61K38/48 , A61K9/00 , A61K9/06 , A61K47/36 , A61K47/26 , A61K47/02 , A61K47/10 , A61P35/00 , A61P17/02
CPC分类号： A61K38/4873 , A61K9/0014 , A61K9/06 , A61K47/36 , A61K47/26 , A61K47/02 , A61K47/10 , A61P35/00 , A61P17/02 , C12Y304/22032
摘要： The present invention provides methods for treating skin cancers utilizing pharmaceutical formulations in the form of a hydrogel that includes a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent. In particular, the method is useful for treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.
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公开(公告)号：US20180036392A1
公开(公告)日：2018-02-08
申请号：US15789045
申请日：2017-10-20
申请人： Merry Richon
发明人： Merry Richon
CPC分类号： A61K38/4873 , A61K9/0014 , A61K47/10 , A61K47/14 , A61K47/44 , C12Y304/22032 , C12Y304/22033
摘要： Compositions containing bromelain are disclosed for use as topical therapeutic agents for the treatment of eczema. The compositions include lotions, creams and ointments.
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公开(公告)号：US20180036390A1
公开(公告)日：2018-02-08
申请号：US15789018
申请日：2017-10-20
申请人： Merry Richon
发明人： Merry Richon
CPC分类号： A61K38/4873 , A61K9/0014 , A61K47/10 , A61K47/14 , A61K47/44 , C12Y304/22032 , C12Y304/22033
摘要： Compositions containing bromelain are disclosed for use as topical therapeutic agents for the treatment of rosacea. The compositions include lotions, creams and ointments.
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9.发明授权Compositions and kits for enzymatic debridement and methods of using the same 有权用于酶清创的组合物和试剂盒及其使用方法公开(公告)号：US09592280B2
公开(公告)日：2017-03-14
申请号：US14511912
申请日：2014-10-10
发明人： Joseph Charles Salamone , Kelly Xiaoyu Chen Leung , Ann Beal Salamone , Katelyn Elizabeth Reilly
IPC分类号： A61K38/54 , A61K31/155 , A61K31/785 , A61K38/47 , A61K45/06 , A61L26/00 , A61L15/38 , A61L15/44
CPC分类号： A61K38/54 , A61K31/155 , A61K31/785 , A61K38/47 , A61K45/06 , A61L15/38 , A61L15/44 , A61L26/0047 , A61L26/0066 , A61L2300/206 , A61L2300/254 , A61L2300/402 , A61L2300/404 , A61L2300/45 , C12Y302/01001 , C12Y302/01002 , C12Y302/01003 , C12Y304/22032 , C12Y304/24007 , A61K2300/00
摘要： A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the debridement of devitalized tissue.
摘要翻译： 描述了坏死组织的清创酶，其不依赖于蛋白水解酶活性，而是利用酶的淀粉酶家族。 注意到淀粉酶（α-，β-，γ-淀粉酶）用于多糖的α-糖苷键的切割，产生较低分子量的碳水化合物/糖片段。 现在已经发现α-淀粉酶在清除失活的组织中是有效的。
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10.发明授权Proteolytic extract from bromelain for the treatment of connective tissue disorders 有权来自菠萝蛋白酶的蛋白水解提取物用于治疗结缔组织疾病公开(公告)号：US09511126B2
公开(公告)日：2016-12-06
申请号：US14233082
申请日：2012-07-19
申请人： Lior Rosenberg , Guy Rubin , Eilon Asculai
发明人： Lior Rosenberg , Guy Rubin , Eilon Asculai
IPC分类号： A61K38/48 , A61K38/43 , A61K135/00 , A61K36/88 , A61K45/06
CPC分类号： A61K38/4873 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K36/88 , A61K38/1732 , A61K45/06 , C12Y304/22031 , C12Y304/22032 , A61K2300/00
摘要： The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition that includes proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.
摘要翻译： 本发明涉及由菠萝蛋白酶获得的用于治疗结缔组织疾病的蛋白水解提取物。 特别地，本发明涉及药物组合物，其包含从菠萝蛋白酶获得的蛋白水解提取物，用于治疗诸如Dupuytren氏病和Peyronie氏病的疾病。
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