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公开(公告)号：US20240269252A1
公开(公告)日：2024-08-15
申请号：US18544197
申请日：2023-12-18
IPC分类号： A61K39/00 , A61K31/704 , A61K31/7068 , A61K39/39
CPC分类号： A61K39/001153 , A61K39/39 , A61K31/704 , A61K31/7068 , A61K2039/545 , A61K2039/55561 , A61K2039/572 , A61K2039/6087 , A61K2039/6093 , A61K2039/804
摘要： Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic stem and progenitor cells. It is a devastating disease with a poor prognosis and an average 5-year survival rate of about 30%. Disclosed herein are composition and methods for treating leukemia with a biomaterial comprising a polymer scaffold, a dendritic cell activating factor, a dendritic cell recruitment factor, and at least one leukemia antigen. The biomaterial-based vaccine disclosed herein promotes a potent, durable and transferable immune response against acute myeloid leukemia to prevent cell engraftment and synergizes with chemotherapy to prevent relapse.
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公开(公告)号：US11998593B2
公开(公告)日：2024-06-04
申请号：US16877274
申请日：2020-05-18
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/395 , A61K47/34 , A61K47/36 , C07K16/28 , C07K16/30 , C12N7/00
CPC分类号： A61K39/0011 , A61K39/001102 , A61K39/001156 , A61K39/001157 , A61K39/00117 , A61K39/001171 , A61K39/00118 , A61K39/001182 , A61K39/001186 , A61K39/001191 , A61K39/001192 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/3955 , A61K47/34 , A61K47/36 , C07K16/2803 , C07K16/2818 , C07K16/30 , C07K16/3053 , C12N7/00 , A61K2039/507 , A61K2039/5152 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , C07K2317/21 , C07K2317/24
摘要： The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer.
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公开(公告)号：US20240165302A1
公开(公告)日：2024-05-23
申请号：US18224444
申请日：2023-07-20
IPC分类号： A61L27/54 , A61L27/20 , A61L27/52 , A61L27/56 , C12N5/0789
CPC分类号： A61L27/54 , A61L27/20 , A61L27/52 , A61L27/56 , C12N5/0647 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2400/18 , A61L2430/02 , C12N2501/155 , C12N2533/74
摘要： Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.
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公开(公告)号：US20230386697A1
公开(公告)日：2023-11-30
申请号：US18031510
申请日：2021-10-12
CPC分类号： H01B1/124 , H01B1/18 , C08L33/26 , C08B37/0084
摘要： Disclosed herein are viscoelastic conductive composite. The viscoelastic conductive composite includes a viscoelastic conductive material; and a conductive filler. The viscoelastic conductive material has a viscoelastic property that matches the viscoelastic property of a tissue.
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公开(公告)号：US20230340404A1
公开(公告)日：2023-10-26
申请号：US18072449
申请日：2022-11-30
IPC分类号： C12N5/00 , A61P35/00 , A61K9/00 , A61K35/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/395 , A61L27/02 , A61L27/28 , A61L27/38 , A61L27/54 , A61L27/56 , C12N5/0783
CPC分类号： C12N5/0075 , A61P35/00 , A61K9/0019 , A61K35/17 , A61K38/1841 , A61K38/193 , A61K38/2013 , A61K39/0011 , A61K39/395 , A61L27/025 , A61L27/28 , A61L27/3804 , A61L27/54 , A61L27/56 , C12N5/0638 , A61L2300/426 , A61L2300/45 , C12N2501/15 , C12N2501/22 , C12N2501/2302 , C12N2501/998 , C12N2533/00 , C12N2533/20
摘要： Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.
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公开(公告)号：US11638748B2
公开(公告)日：2023-05-02
申请号：US17015177
申请日：2020-09-09
发明人： Michael Super , Edward J. Doherty , Mark Joseph Cartwright , Des White , Alexander Stafford , Omar Abdel-Rahman Ali , Amanda Graveline , Donald E. Ingber , David J. Mooney , Benjamin Seiler
IPC分类号： A61K39/02 , A61K39/108 , A61K39/00
摘要： The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.
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公开(公告)号：US20220107308A1
公开(公告)日：2022-04-07
申请号：US17501821
申请日：2021-10-14
IPC分类号： G01N33/545 , A61K35/17 , C08J9/00 , C08J9/12 , C08J9/26 , A61L31/14 , A61L31/16 , A61K35/15 , A61L31/06 , G01N33/569
摘要： Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.
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公开(公告)号：US11197944B2
公开(公告)日：2021-12-14
申请号：US15776853
申请日：2016-11-18
发明人： Christine A. Cezar , Conor J. Walsh , David J. Mooney , Ellen T. Roche , Herman H. Vandenburgh , Georg N. Duda
摘要： The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.
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公开(公告)号：US10758573B2
公开(公告)日：2020-09-01
申请号：US15580710
申请日：2016-06-09
发明人： Pascal Joly , Georg N. Duda , Thomas Schaus , Anke Dienelt , Andrea Sass , David J. Mooney
IPC分类号： A61K35/32 , C12N5/078 , A61K35/12 , C07K14/705 , C12N15/115
摘要： The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.
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