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公开(公告)号：US20240301179A1
公开(公告)日：2024-09-12
申请号：US18591870
申请日：2024-02-29
IPC分类号： C08L5/08 , A61K9/06 , A61K47/36 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/58 , C08J3/075
CPC分类号： C08L5/08 , A61K9/06 , A61K47/36 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/58 , C08J3/075 , C08J2305/08 , C08L2201/06 , C08L2203/02 , C08L2312/00
摘要： In some aspects, the present disclosure pertains to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In other aspects, the present disclosure pertains to systems for forming a hydrogel composition that comprise (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In further aspects, the present disclosure pertains to methods of treatment using such systems.
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公开(公告)号：US20220242817A1
公开(公告)日：2022-08-04
申请号：US17572905
申请日：2022-01-11
发明人： Yiqing Tang , Francesco Cuda , Cristian Parisi , Koorosh Ashrafi , Sean L. Willis , Curry Brown
IPC分类号： C07C237/46
摘要： The present disclosure pertains to iodinated compounds that comprise at least one 2,4,6-triiodobenzene moiety in which at least one of the hydrogens at 1-, 3- and 5-positions of the 2,4,6-triiodobenzene moiety is substituted by an iodinated substituent that comprises one or more iodophenyl-containing groups. The present disclosure also pertains to compositions containing such iodinated compounds and methods of making such iodinated compounds.
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公开(公告)号：US20240360078A1
公开(公告)日：2024-10-31
申请号：US18663548
申请日：2024-05-14
发明人： Yiqing Tang , Francesco Cuda , Cristian Parisi , Koorosh Ashrafi , Sean L. Willis , Curry Brown
IPC分类号： C07C237/46
CPC分类号： C07C237/46
摘要： The present disclosure pertains to iodinated compounds that comprise at least one 2,4,6-triiodobenzene moiety in which at least one of the hydrogens at 1-, 3- and 5-positions of the 2,4,6-triiodobenzene moiety is substituted by an iodinated substituent that comprises one or more iodophenyl-containing groups. The present disclosure also pertains to compositions containing such iodinated compounds and methods of making such iodinated compounds.
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公开(公告)号：US20240293572A1
公开(公告)日：2024-09-05
申请号：US18590582
申请日：2024-02-28
CPC分类号： A61K47/6903 , A61K47/61 , A61K47/64
摘要： In some aspects, the present disclosure provides therapeutic-agent-releasing polyamino compounds that comprise a polyamino moiety that is covalently linked to a residue of a hydroxyl-substituted therapeutic agent by an ester bond. In various embodiments, such therapeutic-agent-releasing polyamino compounds are used to form therapeutic-agent-releasing hydrogels. In other aspects, the present disclosure provides therapeutic-agent-releasing polysaccharides that comprise a plurality of hydroxyl-substituted therapeutic agent residues that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide.
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公开(公告)号：US20240189485A1
公开(公告)日：2024-06-13
申请号：US18516271
申请日：2023-11-21
CPC分类号： A61L27/50 , A61L27/16 , A61L2300/202
摘要： The disclosure pertains to radiopaque, unsaturated multi-arm polymers that comprise a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage. In some embodiments, the disclosure pertains to systems for forming hydrogels, which systems comprise (a) a polyamino compound and (b) a radiopaque, unsaturated multi-arm polymer that comprises a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage, wherein the one or more unsaturated groups are reactive with the amino groups of the polyamino compound. Other embodiments pertain to methods of treatment using such systems and to hydrogels formed from such systems.
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公开(公告)号：US20240335568A1
公开(公告)日：2024-10-10
申请号：US18627837
申请日：2024-04-05
IPC分类号： A61K49/04
CPC分类号： A61K49/0438 , A61K49/0457 , A61K49/0495
摘要： In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a radiopaque polysaccharide that comprises a plurality of radiopaque moieties that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a carboxylate-anion-containing polysaccharide that is ionically crosslinked by multivalent cations. In other aspects, the present disclosure pertains to kits that contain such radiopaque hydrogel compositions, to methods of treatment that comprise administering such radiopaque hydrogel compositions to patients, and to methods of making such radiopaque hydrogel compositions.
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公开(公告)号：US20240218122A1
公开(公告)日：2024-07-04
申请号：US18400970
申请日：2023-12-29
发明人： Yen-Hao Hsu , Cristian Parisi
CPC分类号： C08G65/2609 , A61K51/00 , C08G65/2624 , C08J3/02 , C08G2210/00 , C08J2371/02
摘要： In some embodiments, the present disclosure pertains to multi-arm polymers having at least one polymer arm that comprises a reactive radiopaque end moiety. The radiopaque end moiety comprises a radiopaque dicarboxylic acid ester moiety containing one or more radiopaque atoms, wherein one of two ester groups of the radiopaque dicarboxylic acid ester moiety forms a link to the polymer arm, and wherein the other of the two ester groups of the radiopaque dicarboxylic acid ester moiety corresponds to a portion of a reactive electrophilic group. The present disclosure also pertains to methods of forming such multi-arm polymers and to hydrogels formed from such multi-arm polymers and a polyamino compound comprising a plurality of primary amine groups that form crosslinks with the multi-arm polymers. The present disclosure further pertains to methods and systems for forming such hydrogels and methods of treatment using such hydrogels.
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公开(公告)号：US20230021742A1
公开(公告)日：2023-01-26
申请号：US17862236
申请日：2022-07-11
摘要： In some embodiments, the present disclosure pertains to liquid compositions for medical use that comprise (a) a polymer, a monomer, a macromonomer, or a combination of any two or all three of the foregoing and (b) spherical metallic particles, which may comprise, for example, tantalum, tungsten, rhenium, niobium, molybdenum, and alloys of the foregoing. In some embodiments, the present disclosure pertains to medical methods that comprise administering such liquid compositions to a patient. In some embodiments, the present disclosure pertains to use of such liquid compositions as liquid embolics, fiducial markers, tissue-spacing materials, or therapeutic agent depots. In some embodiments, the present disclosure pertains to medical devices that comprise coatings formed from such liquid compositions.
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9.发明公开公开(公告)号：US20240358896A1
公开(公告)日：2024-10-31
申请号：US18649602
申请日：2024-04-29
CPC分类号： A61L27/54 , A61L27/26 , A61L27/52 , A61L27/58 , A61L2400/06
摘要： In some embodiments, the present disclosure pertains to an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to kits that comprise a syringe preloaded with an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to methods of treatment comprising injecting into a subject an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers.
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公开(公告)号：US20240316220A1
公开(公告)日：2024-09-26
申请号：US18614277
申请日：2024-03-22
CPC分类号： A61K49/0442 , A61K49/0073 , A61K49/0438 , A61M5/19
摘要： In some aspects, the present disclosure pertains to systems for forming a crosslinked polymer composition, the systems comprising (a) an iodinated multifunctional compound comprising either a plurality of electron-rich dienophile-containing moieties or a plurality of electron-poor diene-containing moieties and (b) a multifunctional multi-arm polymer comprising either a plurality of electron-poor diene-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-rich dienophile-containing moieties or a plurality of electron-rich dienophile-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-poor diene-containing moieties, wherein the crosslinked polymer composition is formed by a cycloaddition reaction occurring between the iodinated multifunctional compound and the multifunctional multi-arm polymer. Other aspects of the present disclosure pertain to crosslinked networks formed by such systems and to methods of treatment using such systems.
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