公开(公告)号：US11801326B2

公开(公告)日：2023-10-31

申请号：US17064434

申请日：2020-10-06

申请人： MicroVention, Inc.

发明人： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC分类号： A61L24/06 ,  A61L24/00 ,  A61K49/04 ,  A61K49/12

CPC分类号： A61L24/06 ,  A61K49/0442 ,  A61K49/12 ,  A61L24/001 ,  A61L24/0015 ,  A61L2300/44 ,  A61L2400/06 ,  A61L2430/36 ,  A61L24/06 ,  C08L33/08 ,  A61L24/06 ,  C08L33/26

摘要： Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US20190231908A1

公开(公告)日：2019-08-01

申请号：US16381628

申请日：2019-04-11

申请人： Biosphere Medical, Inc.

发明人： Philippe Reb

IPC分类号： A61K49/18 ,  A61K9/16 ,  A61K47/02 ,  A61K9/00 ,  C07C231/08 ,  A61K49/04 ,  A61K31/704 ,  A61K49/12 ,  C08F220/58

CPC分类号： A61K49/1818 ,  A61K9/0019 ,  A61K9/1635 ,  A61K31/704 ,  A61K47/02 ,  A61K49/0438 ,  A61K49/0442 ,  A61K49/048 ,  A61K49/126 ,  A61K49/1854 ,  C07C231/08 ,  C08F220/58 ,  C08F222/385 ,  C07C237/52

摘要： Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.

公开(公告)号：US20190111159A1

公开(公告)日：2019-04-18

申请号：US16122317

申请日：2018-09-05

申请人： Biocompatibles UK Ltd.

发明人： Stéphane HOHN ,  Andrew Lennard LEWIS ,  Sean Leo WILLIS ,  Matthew R. DREHER ,  Koorosh ASHRAFI ,  Yiqing TANG

IPC分类号： A61K49/04 ,  C08F116/06 ,  A61L24/06 ,  A61L24/00

CPC分类号： A61K49/0442 ,  A61K49/04 ,  A61K49/0433 ,  A61K49/0438 ,  A61K49/0457 ,  A61K49/0476 ,  A61K49/048 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2400/06 ,  A61L2430/36 ,  C08F116/06

摘要： This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system

公开(公告)号：US20180126045A1

公开(公告)日：2018-05-10

申请号：US15706560

申请日：2017-09-15

申请人： ENDOSHAPE, INC.

发明人： Stephen D. GOODRICH

IPC分类号： A61L31/04 ,  C08F222/18 ,  A61L31/18 ,  C08F8/20 ,  A61K49/04

CPC分类号： A61L31/048 ,  A61K49/0442 ,  A61L31/18 ,  A61L2400/16 ,  C08F8/20 ,  C08F220/22 ,  C08F220/30 ,  C08F222/18 ,  C08F12/08 ,  C08F2220/303 ,  C08F2222/1013

摘要： Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.

公开(公告)号：US20180044315A1

公开(公告)日：2018-02-15

申请号：US15550787

申请日：2016-02-12

申请人： SOOCHOW UNIVERSITY

发明人： Zhiyuan ZHONG ,  Yan ZOU ,  Yaohua WEI ,  Fenghua MENG

IPC分类号： C07D319/06 ,  A61L27/18 ,  A61K31/704 ,  A61K47/34 ,  C08G64/02 ,  A61L27/58 ,  A61K49/04

CPC分类号： C07D319/06 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/1641 ,  A61K31/704 ,  A61K47/34 ,  A61K49/0442 ,  A61L27/18 ,  A61L27/58 ,  B82Y30/00 ,  B82Y40/00 ,  C08G63/64 ,  C08G64/0233 ,  C08G64/025 ,  C08G64/30 ,  C08G2230/00 ,  C08L67/04

摘要： The disclosure relates to a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present disclosure can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media.

公开(公告)号：US09789231B2

公开(公告)日：2017-10-17

申请号：US14766626

申请日：2014-02-07

申请人： ENDOSHAPE, INC.

发明人： Stephen D. Goodrich

IPC分类号： C08F220/30 ,  A61K31/04 ,  C08F8/20 ,  A61L31/04 ,  A61K49/04 ,  A61L31/18 ,  C08F222/18 ,  C08F220/22

CPC分类号： A61L31/048 ,  A61K49/0442 ,  A61L31/18 ,  A61L2400/16 ,  C08F8/20 ,  C08F220/22 ,  C08F220/30 ,  C08F222/18 ,  C08F12/08 ,  C08F2220/303 ,  C08F2222/1013

摘要： Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.

公开(公告)号：US20160228556A1

公开(公告)日：2016-08-11

申请号：US14916477

申请日：2014-09-05

申请人： BIOCOMPATIBLES UK LTD

发明人： Stéphane Hohn ,  Andrew Lennard Lewis ,  Sean Leo Willis ,  Matthew R. Dreher ,  Koorosh Ashrafi ,  Yiqing Tang

IPC分类号： A61K47/34 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/555 ,  A61K31/704 ,  A61K31/44

CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K31/404 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/555 ,  A61K31/704 ,  A61K49/0442 ,  A61K49/0457 ,  A61K49/048

摘要： Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.

摘要翻译： 不透射线的水凝胶，特别是不透射线的水凝胶微球，其包含具有用不透射线物质缩醛化的1,2-二醇或1,3-二醇基团的聚合物。

公开(公告)号：US20160177028A1

公开(公告)日：2016-06-23

申请号：US14983801

申请日：2015-12-30

申请人： Rutgers, The State University of New Jersey

发明人： Durgadas Bolikal ,  Joachim B. Kohn

IPC分类号： C08G64/10 ,  C08G81/00 ,  C07C69/94

CPC分类号： C08G64/10 ,  A61K49/0442 ,  C07C69/84 ,  C08G63/64 ,  C08G81/00

摘要： Disclosed are monomeric compounds which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.

摘要翻译： 公开了可以聚合以形成新的可生物降解和生物可再吸收的聚合物和共聚物的单体化合物。 这些聚合物和共聚物虽然不限于此，但可适用于放射性能力，并且可用于医疗器械应用和控制释放治疗剂型。

公开(公告)号：US09186422B2

公开(公告)日：2015-11-17

申请号：US13587605

申请日：2012-08-16

申请人： Chandrashekhar P. Pathak ,  Sanjay M. Thigle

发明人： Chandrashekhar P. Pathak ,  Sanjay M. Thigle

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K49/04 ,  C08G63/682 ,  C08G63/91 ,  C08G64/02 ,  C08H1/00

CPC分类号： A61K49/0442 ,  C08G63/6822 ,  C08G63/912 ,  C08G64/0233 ,  C08H1/00

摘要： Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable property of the compositions renders them suitable for use in medical field such as drug delivery, imaging. Compounds disclosed in this invention exist as neat liquid. Certain compositions disclosed in this invention form hydrophobic iodine rich domains when dissolved in water, such domains provide better contrasting properties as well as ability to dissolve hydrophobic bioactive drugs. Certain iodinated moieties disclosed in the invention are capable of cross linking natural proteins in situ in presence of suitable catalysts and co-catalysts.

摘要翻译： 不透射线的可生物降解组合物是通过用碘化部分修饰合成和天然可生物降解的聚合物（如聚内酯）的端基形成的。 组合物的可生物降解性使其适合用于药物输送，成像等医学领域。 本发明中公开的化合物作为纯液体存在。 当溶解在水中时，本发明中公开的某些组合物形成疏水富碘结构域，这些结构域提供更好的对比性质以及溶解疏水性生物活性药物的能力。 本发明中公开的某些碘化部分能够在合适的催化剂和助催化剂存在下原位交联天然蛋白质。

公开(公告)号：US20150290344A1

公开(公告)日：2015-10-15

申请号：US14683775

申请日：2015-04-10

申请人： Clemson University ,  College of Charleston

发明人： Frank Alexis ,  Daniel C. Whitehead ,  Brooke A. Van Horn

IPC分类号： A61K49/04 ,  C08L67/04 ,  A61L31/18 ,  A61L17/14 ,  A61L29/08 ,  A61L29/18 ,  A61L27/50 ,  A61L27/34 ,  C08G63/91 ,  A61L31/10

CPC分类号： A61K49/0442 ,  A61L17/145 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/18 ,  A61L31/10 ,  A61L31/18 ,  A61L2300/44 ,  C08G63/08 ,  C08G63/91 ,  C08G63/912 ,  C08L67/04 ,  C08L101/00

摘要： Biodegradable, radio-opaque polyesters and poly(ester amides) are described herein. The polyesters contain a plurality of radio-opaque agents or radio-opaque agent-containing moieties that are covalently bound along or from the polymer backbone. The agents/moieties may be bound to the termini of the polymer provided they are bound within the polyester backbone as well. The polyester can be aliphatic or aromatic. The polyester and poly(ester amide) is substituted with a plurality of radio-opaque graft agents or prepared from an appropriate radio-opaque monomer agent. The materials can be used for any application where a radio-opaque material is desired or necessary. The materials can be used to form, in whole or in part, a medical device, or coating thereon or therein.

摘要翻译： 可生物降解的，不透射线的聚酯和聚（酯酰胺）在本文中描述。 聚酯包含多个不透射线剂或含聚合物主链共价键共价结合的不透射线剂。 所述试剂/部分可以结合到聚合物的末端，只要它们在聚酯骨架内结合即可。 聚酯可以是脂肪族或芳族的。 聚酯和聚（酯酰胺）被多个不透射线的接枝剂取代或者由适当的不透射线的单体剂制备。 这些材料可用于需要或不需要不透射线材料的任何应用。 这些材料可以全部或部分地用于形成医疗装置，或其上或其上的涂层。