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    METAL OXIDE NANOPARTICLE FOR CELL LYSIS
    2.
    发明申请
    METAL OXIDE NANOPARTICLE FOR CELL LYSIS 审中-公开

    公开(公告)号：US20180036426A1

    公开(公告)日：2018-02-08

    申请号：US15554423

    申请日：2016-03-31

    申请人： UCHICAGO ARGONNE, LLC

    发明人： Tijana RAJH ,  Bartosz GRYZBOWSKI ,  Elena A. ROZHKOVA ,  Harry C. FRY ,  Nada DIMITRIJEVIC ,  Tamara KORITAROV

    IPC分类号： A61K47/68 ,  A61K47/69 ,  C12Q1/66

    CPC分类号： A61K47/6863 ,  A61K47/6923 ,  A61K49/12 ,  C12Q1/66

    摘要： A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.

    Compositions and Methods to Image and Quantify Inflammation
    4.
    发明申请
    Compositions and Methods to Image and Quantify Inflammation 审中-公开
    图像和量化炎症的组成和方法

    公开(公告)号：US20160235872A1

    公开(公告)日：2016-08-18

    申请号：US15043004

    申请日：2016-02-12

    申请人： Celsense, Inc.

    发明人： Brooke M. Helfer ,  Anthony G. Balducci ,  Charles F. O'Hanlon, III

    IPC分类号： A61K51/12 ,  A61B5/055 ,  A61K51/04

    CPC分类号： A61K49/126 ,  A61B5/055 ,  A61K49/12 ,  A61K49/1896 ,  A61K51/0423 ,  A61K51/1203

    摘要： Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19F-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of inflammation, thus permitting non-invasive evaluation of inflammation in patients. The present methods provide a tool for assessing inflammation in a wide variety of autoimmune diseases and may have particular utility in intestinal diseases such as Crohn's disease, ulcerative colitis, inflammatory bowel disease, and cardio myositis.

    摘要翻译： 用于评估受试者炎症的组合物和方法。 该预设的公开内容提供了用离子标记含有19F的全氟聚醚分子标记白细胞的组合物。 在一些实例中，从患者获得白细胞，富集全血分数，然后标记。 可以将标记的细胞重新导入患者体内。 白细胞可能积聚在炎症部位，从而允许对患者的炎症进行非侵入性评估。 本发明的方法提供了用于评估多种自身免疫疾病中的炎症的工具，并且可以在诸如克罗恩病，溃疡性结肠炎，炎性肠病和心脏肌炎的肠道疾病中具有特别的用途。

    Manganese comprising nanostructures
    8.
    发明授权
    Manganese comprising nanostructures 有权
    包含纳米结构的锰

    公开(公告)号：US09040637B2

    公开(公告)日：2015-05-26

    申请号：US14345461

    申请日：2012-09-20

    申请人： SPAGO IMAGING AB

    发明人： Oskar Axelsson ,  Rodrigo M. Petoral, Jr. ,  Fredrik Ek ,  Petter Lauritzson

    IPC分类号： A61K51/06 ,  C08G73/02 ,  A61K49/12 ,  A61K49/18 ,  B82Y5/00 ,  B82Y15/00

    CPC分类号： A61K51/065 ,  A61K49/12 ,  A61K49/124 ,  A61K49/128 ,  A61K49/1818 ,  A61K49/1857 ,  B82Y5/00 ,  B82Y15/00 ,  C08G73/0206 ,  C08G73/0213

    摘要： Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as —R3R4C(P═O(OR1)(OR2))2, wherein R1 and R2 are independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of R3 and R4 is a group connected to the polymeric framework with the proviso that when only one of R3 and R4 is such a connected group, the other of R3 and R4 is either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, OR5 and R5, wherein R5 is a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese containing nanostructures, i.a. as MRI contrasting agents.

    摘要翻译： 本文公开了包含包含至少五个偕二膦酸酯基团的聚合物骨架的纳米结构，其中彼此独立地偕双膦酸酯基团以-R3R4C（P = O（OR1）（OR2））2）并入，其中R1和R2独立地选自 由负电荷，H，烷基和芳基组成的组，并且其中R 3和R 4中的至少一个是与聚合物骨架连接的基团，条件是当只有R3和R4之一是这样的连接基团时， R3和R4中的另一个是能够连接到聚合物骨架的基团，或这种基团的残基，或选自H，OH，OR 5和R 5，其中R 5是低级烷基。 聚合物骨架可以包含锰离子。 还公开了生产这种含锰纳米结构的方法，包含这种含锰纳米结构的组合物和使用这种含锰纳米结构的方法，例如， 作为MRI造影剂。

    NOVEL TARGETED PARAMAGNETIC CONTRAST AGENT
    10.
    发明申请
    NOVEL TARGETED PARAMAGNETIC CONTRAST AGENT 审中-公开
    新型目标参考对比剂

    公开(公告)号：US20130302255A1

    公开(公告)日：2013-11-14

    申请号：US13888675

    申请日：2013-05-07

    申请人： BBS NANOMEDICINA ZRT.

    发明人： János BORBÉLY ,  István HAJDÚ ,  Magdolna BODNÁR ,  Ildikó SCRIFFERTNÉ DENYICSKA

    IPC分类号： A61K49/08 ,  A61K49/18 ,  A61K49/12

    CPC分类号： A61K49/085 ,  A61K49/12 ,  A61K49/128 ,  A61K49/146 ,  A61K49/1818 ,  A61K49/1824

    摘要： Disclosed are novel, targeting, paramagnetic nanoparticles as contrast agent for magnetic resonance imaging. The compositions of the nanoparticles are composed of self-assembled polyelectrolyte biopolymers having targeting moieties, which can suitable for targeted delivery of paramagnetic ions complexed to the nanoparticles. The nanoparticulate contrast agent can internalize into the targeted tumor cells to realize the receptor mediated uptake, and therefore afford enhanced relaxivity and improved signal-to-noise effect on the examined tissue areas. Methods for making these targeting MRI contrast agents are also provided.

    摘要翻译： 公开了用于磁共振成像的新型靶向，顺磁性纳米颗粒作为造影剂。 纳米颗粒的组成由具有靶向部分的自组装聚电解质生物聚合物组成，其可适用于与纳米颗粒络合的顺磁离子的靶向递送。 纳米颗粒造影剂可以内化到靶向的肿瘤细胞中以实现受体介导的摄取，因此提供增强的松弛度和改善的对所检查的组织区域的信噪比的影响。 还提供了制备这些靶向MRI造影剂的方法。