DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT
    3.
    发明申请
    DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT 有权
    药物载体提供MRI对比增强

    公开(公告)号:US20110177009A1

    公开(公告)日:2011-07-21

    申请号:US13062550

    申请日:2009-09-03

    摘要: Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.

    摘要翻译: 描述了可用于磁共振成像(MRI)指导的药物释放的药物载体,其包含能够释放作为局部刺激的结果的封闭的生物活性剂的壳,例如, 能量输入,例如热量,其中壳体包围19F MR造影剂。 优选地,基于化学交换依赖性饱和转移(CEST)的原理,载体也用作MRI的对比度增强剂。 为此,壳体包围包含顺磁化学位移试剂,质子分析物池和19F造影剂的空腔,并且其中壳允许质子分析物的扩散。

    FERROELECTRIC VARACTOR WITH IMPROVED TUNING RANGE
    4.
    发明申请
    FERROELECTRIC VARACTOR WITH IMPROVED TUNING RANGE 审中-公开
    具有改进的调谐范围的电磁变压器

    公开(公告)号:US20100182730A1

    公开(公告)日:2010-07-22

    申请号:US12447078

    申请日:2007-10-19

    IPC分类号: H01G7/06 H01G7/00

    CPC分类号: H01G7/06 H01G7/028

    摘要: The present invention relates to a ferroelectric varactor (400) that comprises a dielectric-layer stack (408) between electrodes (406, 410). The dielectric-layer stack comprises an alternating layer sequence of at least three dielectric layers. At cc least two first dielectric layers of the dielectric-layer stack are made of a non-single-crystalline first dielectric material having a first dielectric constant, at least one second dielectric layer of the dielectric-layer stack is made of a non-single-crystalline second dielectric material with a second dielectric constant that differs from the first dielectric constant. One of the first and second dielectric materials exhibits a weaker ferroelectric hysteresis. The dielectric material with the weaker ferroelectric hysteresis makes up more than 20% of the total volume of the dielectric-layer stack. The ferroelectric varactor of the present invention achieves high relative dielectric permittivities in the dielectric layers, a high breakdown voltage, a large tuning range at low voltages, and low dielectric losses.

    摘要翻译: 本发明涉及一种铁电变容二极管(400),其包括电极(406,410)之间的电介质层叠层(408)。 介电层堆叠包括至少三个电介质层的交替层序列。 在cc的介电层堆叠的至少两个第一电介质层由具有第一介电常数的非单晶第一介电材料制成,介电层堆叠的至少一个第二介电层由非单一的 具有不同于第一介电常数的第二介电常数的晶体第二电介质材料。 第一和第二介电材料之一表现出较弱的铁电滞后。 具有较弱的铁电滞后的电介质材料占电介质层叠层总体积的20%以上。 本发明的铁电变容二极管在电介质层中实现高相对介电常数,高击穿电压,低电压下的大调谐范围以及低介电损耗。