公开(公告)号：US20250000954A1

公开(公告)日：2025-01-02

申请号：US18754776

申请日：2024-06-26

Applicant: Boston Scientific Scimed, Inc.

Inventor： Heather Cirka ,  Yen-Hao Hsu ,  Marc Plourde ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

IPC: A61K38/46 ,  A61M5/178 ,  A61N5/10

Abstract: Systems for hydrogel hydrolysis as well as methods for hydrogel hydrolysis are disclosed. An example system may include a syringe barrel having a needle connector disposed thereon. A hydrogel hydrolysis material may be disposed in the syringe barrel. The hydrogel hydrolysis material may be configured to be injected into a hydrogel formed in the body of a patient in order to accelerate the hydrolysis of the hydrogel.

公开(公告)号：US20240293583A1

公开(公告)日：2024-09-05

申请号：US18591471

申请日：2024-02-29

Applicant: Boston Scientific Scimed, Inc.

Inventor： Heather Cirka ,  Yen-Hao Hsu

IPC: A61K49/04 ,  A61K45/06

CPC classification number: A61K49/0438 ,  A61K45/06 ,  A61K49/0419 ,  A61K49/0457

Abstract: The present disclosure provides radiopaque crosslinked acrylamide copolymers that comprise (a) a monofunctional acrylamide monomer containing one or more radiopaque atoms and/or a multifunctional acrylamide monomer containing one or more radiopaque atoms and (b) a monofunctional acrylamide monomer that does not contain one or more radiopaque atoms and/or a multifunctional acrylamide monomer that does not contain one or more radiopaque atoms, wherein the copolymer comprises at least one multifunctional acrylamide monomer. The present disclosure also provides radiopaque particulate compositions that comprise such radiopaque crosslinked acrylamide copolymers and medical procedures that comprise administering to a subject such radiopaque particulate compositions. The present disclosure further provides methods of making such radiopaque crosslinked acrylamide copolymers.

公开(公告)号：US20240335568A1

公开(公告)日：2024-10-10

申请号：US18627837

申请日：2024-04-05

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi ,  Heather Cirka ,  Alexis Compton

IPC: A61K49/04

CPC classification number: A61K49/0438 ,  A61K49/0457 ,  A61K49/0495

Abstract: In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a radiopaque polysaccharide that comprises a plurality of radiopaque moieties that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a carboxylate-anion-containing polysaccharide that is ionically crosslinked by multivalent cations. In other aspects, the present disclosure pertains to kits that contain such radiopaque hydrogel compositions, to methods of treatment that comprise administering such radiopaque hydrogel compositions to patients, and to methods of making such radiopaque hydrogel compositions.

公开(公告)号：US20240164885A1

公开(公告)日：2024-05-23

申请号：US18509987

申请日：2023-11-15

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Heather Cirka ,  Niraj Prasad Rauniyar

IPC: A61F2/00 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61F2/0063 ,  A61L31/048 ,  A61L31/148 ,  A61F2210/0004 ,  A61L2420/02

Abstract: An implant includes a substrate having an outer surface, a first layer disposed on the outer surface of the substrate, and a second layer disposed on the outer surface of the substrate. The first layer includes a polymeric material.