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    RADIOPAQUE CROSSLINKED ACRYLAMIDE COPOLYMERS AND USES THEREOF
    1.
    发明公开
    RADIOPAQUE CROSSLINKED ACRYLAMIDE COPOLYMERS AND USES THEREOF 审中-公开

    公开(公告)号：US20240293583A1

    公开(公告)日：2024-09-05

    申请号：US18591471

    申请日：2024-02-29

    申请人： Boston Scientific Scimed, Inc.

    发明人： Heather Cirka ,  Yen-Hao Hsu

    IPC分类号： A61K49/04 ,  A61K45/06

    CPC分类号： A61K49/0438 ,  A61K45/06 ,  A61K49/0419 ,  A61K49/0457

    摘要： The present disclosure provides radiopaque crosslinked acrylamide copolymers that comprise (a) a monofunctional acrylamide monomer containing one or more radiopaque atoms and/or a multifunctional acrylamide monomer containing one or more radiopaque atoms and (b) a monofunctional acrylamide monomer that does not contain one or more radiopaque atoms and/or a multifunctional acrylamide monomer that does not contain one or more radiopaque atoms, wherein the copolymer comprises at least one multifunctional acrylamide monomer. The present disclosure also provides radiopaque particulate compositions that comprise such radiopaque crosslinked acrylamide copolymers and medical procedures that comprise administering to a subject such radiopaque particulate compositions. The present disclosure further provides methods of making such radiopaque crosslinked acrylamide copolymers.

    Encapsulation Methods and Compositions
    4.
    发明申请
    Encapsulation Methods and Compositions 审中-公开

    公开(公告)号：US20170252304A1

    公开(公告)日：2017-09-07

    申请号：US15446729

    申请日：2017-03-01

    申请人： Prodo Laboratories, Inc.

    发明人： David Scharp ,  Roy McCord

    IPC分类号： A61K9/50 ,  A61K49/04 ,  A61K35/39

    CPC分类号： A61K9/5031 ,  A61K9/0024 ,  A61K31/135 ,  A61K35/39 ,  A61K49/0419 ,  C12N5/0677 ,  C12N2533/40

    摘要： This invention provides methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.

    Water-equivalent phantom
    5.
    发明授权
    Water-equivalent phantom 有权

    公开(公告)号：US09669116B2

    公开(公告)日：2017-06-06

    申请号：US14449928

    申请日：2014-08-01

    申请人： Gammex, Inc.

    发明人： Cristel Baiu

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0419 ,  A61K49/04 ,  A61K49/0409

    摘要： A composition for use in radiology includes glass micro bubbles, Araldite, Jeffamine, magnesium oxide, and polyethylene. Another composition or use in radiology may include glass micro bubbles, an epoxy, acrylic, or polyurethane, and polyethylene. This composition may result in an elemental composition including carbon, oxygen, hydrogen, nitrogen, calcium, and magnesium. A composition for use in radiology may include glass micro bubbles, araldite, jeffamine, calcium carbonate, magnesium oxide, polyethylene, and a pigment and the composition includes an elemental composition including carbon, oxygen, hydrogen, nitrogen, calcium, silicon, and magnesium.

    Water-Equivalent Phantom
    6.
    发明申请
    Water-Equivalent Phantom 有权
    水等效幻影

    公开(公告)号：US20160015836A1

    公开(公告)日：2016-01-21

    申请号：US14449928

    申请日：2014-08-01

    申请人： Gammex, Inc.

    发明人： Cristel Baiu

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0419 ,  A61K49/04 ,  A61K49/0409

    摘要： A composition for use in radiology includes glass micro bubbles, Araldite, Jeffamine, magnesium oxide, and polyethylene. Another composition or use in radiology may include glass micro bubbles, an epoxy, acrylic, or polyurethane, and polyethylene. This composition may result in an elemental composition including carbon, oxygen, hydrogen, nitrogen, calcium, and magnesium. A composition for use in radiology may include glass micro bubbles, araldite, jeffamine, calcium carbonate, magnesium oxide, polyethylene, and a pigment and the composition includes an elemental composition including carbon, oxygen, hydrogen, nitrogen, calcium, silicon, and magnesium.

    摘要翻译： 用于放射学的组合物包括玻璃微气泡，Araldite，Jeffamine，氧化镁和聚乙烯。 放射学中的另一种组合物或用途可包括玻璃微气泡，环氧树脂，丙烯酸或聚氨酯和聚乙烯。 该组合物可以产生包括碳，氧，氢，氮，钙和镁的元素组成。 用于放射学的组合物可以包括玻璃微气泡，阿拉维迪，杰夫胺，碳酸钙，氧化镁，聚乙烯和颜料，并且该组合物包括包含碳，氧，氢，氮，钙，硅和镁的元素组合物。

    Administrable compositions
    7.
    发明授权
    Administrable compositions 有权
    可管理组合

    公开(公告)号：US08709486B2

    公开(公告)日：2014-04-29

    申请号：US12993056

    申请日：2009-05-15

    申请人： Brian Stanley Hawkett ,  Nirmesh Jain ,  Thi Thuy Binh Pham ,  Yanjun Wang ,  Gregory Goodman Warr

    发明人： Brian Stanley Hawkett ,  Nirmesh Jain ,  Thi Thuy Binh Pham ,  Yanjun Wang ,  Gregory Goodman Warr

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0009 ,  A61K9/0019 ,  A61K9/1611 ,  A61K9/1635 ,  A61K41/0052 ,  A61K49/0404 ,  A61K49/0419 ,  A61K51/1244

    摘要： The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state by a steric stabilizer, wherein the steric stabilizer is a polymeric material comprising a steric stabilizing polymeric segment and an anchoring polymeric segment, one or both of which are derived from one or more ethylenically unsaturated monomers that have been polymerized by a living polymerization technique, wherein the steric stabilizing polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the particulate material and secures the stabilizer to the particulate material.

    摘要翻译： 本发明涉及适用于给予受试者的组合物，所述组合物包含分散在药理学上可接受的液体载体中的药理学上可接受的颗粒材料，所述颗粒材料通过空间稳定剂保持在分散状态，其中所述空间稳定剂是聚合物 包含空间稳定聚合物链段和锚定聚合物链段的材料，其中一个或两个衍生自已经通过活性聚合技术聚合的一种或多种烯属不饱和单体，其中所述空间稳定聚合物链段不同于所述锚定聚合物链段 ，并且其中所述锚定聚合物链段对所述颗粒材料的表面具有亲和性，并将所述稳定剂固定在所述颗粒材料上。

    COMPOSITION COMPRISING LOW DENSITY MICROSPHERES
    9.
    发明申请
    COMPOSITION COMPRISING LOW DENSITY MICROSPHERES 审中-公开
    包含低密度微球的组合物

    公开(公告)号：US20080118435A1

    公开(公告)日：2008-05-22

    申请号：US12014154

    申请日：2008-01-15

    申请人： EVAN UNGER

    发明人： EVAN UNGER

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

    摘要： Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.

    摘要翻译： 描述低密度微球，其制备方法及其作为造影剂的用途。 微球体具有空隙，其含有选自脂族烃，氯氟烃，四烷基硅烷和全氟化碳的挥发性液体的气体或蒸汽。

    Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
    10.
    发明申请
    Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same 有权
    用于治疗和/或诊断应用的可负载聚合物颗粒及其制备和使用方法

    公开(公告)号：US20060088476A1

    公开(公告)日：2006-04-27

    申请号：US11257535

    申请日：2005-10-25

    申请人： Philipp Harder ,  Olaf Fritz ,  Ulf Fritz

    发明人： Philipp Harder ,  Olaf Fritz ,  Ulf Fritz

    IPC分类号： A61K49/04

    CPC分类号： A61K9/5031 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5073 ,  A61K9/5078 ,  A61K9/5089 ,  A61K49/0404 ,  A61K49/0419

    摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to the core of the particles as a coating or absorbed within the core of the particles. The particles can be used to minimize blood flow to mammalian tissues by occluding at least a portion of a blood vessel of the mammal, or to deliver an active agent to a localized area within a body of a mammal by contacting a localized area with at least one of the particles. Further, the particles are useful in sustained release formulations including active agent(s) for oral administration, as tracer particles for injection into the bloodstream of a mammal or for use in enhanced ultrasound imaging. The particles may include agents for increasing density for achieving useful buoyancy levels in suspension.

    摘要翻译： 颗粒被提供用于治疗和/或诊断过程。 颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。 颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。 也可以将硫酸钡作为涂层提供到颗粒的芯部或者被吸收在颗粒的芯中。 颗粒可以用于通过闭塞哺乳动物的血管的至少一部分来最小化对哺乳动物组织的血液流动，或者通过使至少一个局部区域与至少一个局部区域接触而将活性剂递送到哺乳动物体内的局部区域 其中一颗颗粒。 此外，该颗粒可用于持续释放制剂，包括用于口服给药的活性剂，作为用于注射到哺乳动物血流中的示踪剂颗粒或用于增强的超声成像。 颗粒可以包括增加密度的试剂，以实现悬浮液中有用的浮力水平。