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公开(公告)号:US11572356B2
公开(公告)日:2023-02-07
申请号:US17004411
申请日:2020-08-27
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , A61K31/506 , C07D239/30 , C07F5/02 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号:US20200038385A1
公开(公告)日:2020-02-06
申请号:US16542746
申请日:2019-08-16
Applicant: BIOGEN MA INC.
Inventor: Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , C07K16/28 , A61K39/395 , A61K38/21 , A61K31/695 , A61K31/55 , A61K31/517 , A61K31/498 , A61K31/4709 , A61K31/4545 , A61K31/225 , C07D215/20 , C07D401/06 , C07D405/12 , C07D211/62 , C07D211/60 , C07D211/34
Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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公开(公告)号:US20190389836A1
公开(公告)日:2019-12-26
申请号:US16481772
申请日:2018-01-29
Applicant: BIOGEN MA INC.
Inventor: Andrew George Capacci , Michael Dechantsreiter , Istvan Enyedy , John H. Jones , Edward Yin-Shiang Lin , Brian Stuart Lucas , Bin Ma
IPC: C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14 , C07D215/14 , C07D405/14 , C07D471/04 , C07D451/02
Abstract: Provided are tetrahydroisoquinoline derivatives as Nrf2 activators.
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公开(公告)号:US20190382394A1
公开(公告)日:2019-12-19
申请号:US16410725
申请日:2019-05-13
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Jürgen Schulz , Marta Nevalainen , Michael Dechantsreiter
IPC: C07D413/14 , C07D405/14 , C07D403/14
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US20190218204A1
公开(公告)日:2019-07-18
申请号:US16108755
申请日:2018-08-22
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07F5/02 , C07D239/30 , A61K31/506 , C07D487/04 , C07D513/04 , C07D401/14 , C07D417/14 , C07D417/12 , C07D409/14 , C07D413/14 , C07D495/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号:US10273234B2
公开(公告)日:2019-04-30
申请号:US14420020
申请日:2013-08-05
Applicant: BIOGEN MA INC.
Inventor: Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D471/08 , A61K31/122 , C07C229/48 , C07D223/06 , C07D205/04 , C07D207/16 , C07D209/52 , C07D211/62 , A61K45/06 , A61K31/397 , A61K31/403 , A61K31/44 , A61K31/55 , A61K31/196 , A61K31/40 , A61K31/439 , A61K31/445 , C07C211/38 , C07D207/08
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号:US20180297992A1
公开(公告)日:2018-10-18
申请号:US15952505
申请日:2018-04-13
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D405/14 , C07D413/14 , A61P43/00
CPC classification number: C07D417/14 , A61K31/44 , A61K31/443 , A61K31/506 , A61P43/00 , C07B2200/13 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US10081619B2
公开(公告)日:2018-09-25
申请号:US15699857
申请日:2017-09-08
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号:US20180093973A1
公开(公告)日:2018-04-05
申请号:US15699857
申请日:2017-12-20
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D495/04 , C07D513/04 , C07D417/12
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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10.Compounds that are S1P modulating agents and/or ATX modulating agents 有权
Title translation: 作为S1P调节剂和/或ATX调节剂的化合物公开(公告)号:US09499485B2
公开(公告)日:2016-11-22
申请号:US14420025
申请日:2013-08-05
Applicant: BIOGEN MA INC.
Inventor: Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D211/62 , A61K31/122 , A61K45/06 , A61K31/192 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , C07C229/14 , C07C229/48 , C07D211/60 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/46 , C07D211/34 , C07D451/14
CPC classification number: C07D211/62 , A61K31/122 , A61K31/192 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/46 , A61K45/06 , C07C229/14 , C07C229/48 , C07C2601/14 , C07D211/34 , C07D211/60 , C07D451/02 , C07D451/14 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式(I)化合物可以调节一种或多种SIP受体的活性和/或自分泌素(ATX)的活性。