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31 条记录 (耗时 0.021 秒)

    Release reagent for vitamin D compounds
    3.
    发明授权
    Release reagent for vitamin D compounds 有权
    维生素D化合物释放试剂

    公开(公告)号：US09341552B2

    公开(公告)日：2016-05-17

    申请号：US14575423

    申请日：2014-12-18

    申请人： Roche Diagnostics Operations, Inc.

    发明人： Apostolos Kyriatsoulis ,  Susanne Feldmann ,  Eramus Huber ,  Nicole Horn ,  Leopold von Proff ,  Uwe Kobold ,  Angela Puhlmann

    IPC分类号： G01N33/82 ,  G01N1/34 ,  C07K16/44 ,  G01N33/52

    CPC分类号： G01N1/34 ,  C07K16/44 ,  G01N33/52 ,  G01N33/82 ,  Y10T436/10

    摘要： The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunological reagents.

    摘要翻译： 本发明涉及用于释放与维生素D结合蛋白结合的维生素D化合物的试剂组合物，使用该维生素D结合蛋白从维生素D结合蛋白中释放25-羟基维生素D化合物的方法 试剂和以这种方式获得的混合物，使用试剂释放维生素D化合物以及用于检测25-羟基维生素D的试剂盒，其中含有用于释放维生素D化合物的试剂以及通常的免疫试剂。

    Method and device for separating metabolites or stereoisomers
    6.
    发明授权
    Method and device for separating metabolites or stereoisomers 有权

    公开(公告)号：US11099154B2

    公开(公告)日：2021-08-24

    申请号：US15366695

    申请日：2016-12-01

    申请人： Roche Diagnostics Operations, Inc. ,  Owlstone Medical Limited

    发明人： Uwe Kobold ,  Roland Thiele ,  Noah Weiss ,  Lauren Brown

    IPC分类号： G01N27/624 ,  G01N33/82 ,  G01N33/487 ,  H01J49/00

    摘要： A method of quantifying the amount of at least two analytes A1 and A2 involving (a) adding at least one salt (S) to at least a portion (P1) of the sample comprising the at least two analytes A1 and A2, (b) ionizing at least a portion of the sample according to (a) thereby forming an analyte flow comprising the analytes A1 and A2 in ionized form, (c) separating the ionized analytes A1 and A2 from each other by using at least one ion mobility separator (124), wherein the analyte flow according to (b) at least partially passes through the ion mobility separator (124), and (d) quantifying the amount of the separated ionized analytes obtained according to (c), wherein A1 is a pharmaceutically active compound C or derivative thereof and A2 is a metabolite or stereoisomer of C.

    Immobilized analytes
    10.
    发明授权
    Immobilized analytes 有权

    公开(公告)号：US11585811B2

    公开(公告)日：2023-02-21

    申请号：US16389066

    申请日：2019-04-19

    申请人： Roche Diagnostics Operations, Inc.

    发明人： Uwe Kobold ,  Robert Lang ,  Andreas Leinenbach

    IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  G01N33/543 ,  G01N33/573

    摘要： A method for detecting an analyte involving a) contacting the analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within the analyte and/or within said capture agent in the capture complex and, thereby, releasing the analyte or a fragment thereof from the capture complex, and c) detecting at least one fragment of the analyte and, thereby, detecting the analyte is disclosed herein. A kit having i) a capture agent binding to an analyte; and ii) an agent cleaving at least one covalent bond within the analyte and/or within the capture agent; and to the use of a protease for releasing fragments of an analyte for detecting the analyte, wherein the analyte is bound to a solid surface via a capture agent is also disclosed herein.