公开(公告)号：US20150104876A1

公开(公告)日：2015-04-16

申请号：US14575423

申请日：2014-12-18

申请人： Roche Diagnostics Operations, Inc.

发明人： Apostolos Kyriatsoulis ,  Susanne Feldmann ,  Eramus Huber ,  Nicole Horn ,  Leopold von Proff ,  Uwe Kobold ,  Angela Puhlmann

IPC分类号： G01N1/34

CPC分类号： G01N1/34 ,  C07K16/44 ,  G01N33/52 ,  G01N33/82 ,  Y10T436/10

摘要： The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunological reagents.

公开(公告)号：US09341552B2

公开(公告)日：2016-05-17

申请号：US14575423

申请日：2014-12-18

申请人： Roche Diagnostics Operations, Inc.

发明人： Apostolos Kyriatsoulis ,  Susanne Feldmann ,  Eramus Huber ,  Nicole Horn ,  Leopold von Proff ,  Uwe Kobold ,  Angela Puhlmann

IPC分类号： G01N33/82 ,  G01N1/34 ,  C07K16/44 ,  G01N33/52

CPC分类号： G01N1/34 ,  C07K16/44 ,  G01N33/52 ,  G01N33/82 ,  Y10T436/10

摘要： The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunological reagents.

摘要翻译： 本发明涉及用于释放与维生素D结合蛋白结合的维生素D化合物的试剂组合物，使用该维生素D结合蛋白从维生素D结合蛋白中释放25-羟基维生素D化合物的方法 试剂和以这种方式获得的混合物，使用试剂释放维生素D化合物以及用于检测25-羟基维生素D的试剂盒，其中含有用于释放维生素D化合物的试剂以及通常的免疫试剂。