公开(公告)号：US20240287117A1

公开(公告)日：2024-08-29

申请号：US18637382

申请日：2024-04-16

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Peng LI ,  Xiaolin LI ,  Yaxun YANG ,  Zhi LUO ,  Haiying HE ,  Shuhui CHEN

IPC: C07H7/06 ,  A61K31/53 ,  C07B59/00

CPC classification number: C07H7/06 ,  A61K31/53 ,  C07B59/005

Abstract: Disclosed are a series of deuterated nucleoside compounds and a use thereof. Specifically disclosed are compounds represented by formula (VI-2), and stereoisomers or pharmaceutically acceptable salts thereof.

公开(公告)号：US20240239761A1

公开(公告)日：2024-07-18

申请号：US18549366

申请日：2022-03-18

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Shengbin ZHANG ,  Tao YU ,  Chengde WU ,  Jinxin LIU ,  Jian LI ,  Shuhui CHEN

IPC: C07D271/07 ,  A61K31/4245

CPC classification number: C07D271/07 ,  A61K31/4245

Abstract: A series of phenol compounds and the use thereof. Specifically disclosed are a compound as represented by formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240199571A1

公开(公告)日：2024-06-20

申请号：US18549188

申请日：2022-03-04

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Lingyun WU ,  Zhen ZHAN ,  Lele ZHAO ,  Jianjun SUN ,  Yi QIAN ,  Shuhui CHEN

IPC: C07D333/22 ,  A61K31/381 ,  A61K31/407 ,  A61K31/438 ,  A61K31/439 ,  A61K31/495 ,  A61K31/551 ,  C07D403/04 ,  C07D413/04

CPC classification number: C07D333/22 ,  A61K31/381 ,  A61K31/407 ,  A61K31/438 ,  A61K31/439 ,  A61K31/495 ,  A61K31/551 ,  C07D403/04 ,  C07D413/04

Abstract: The present invention relates to a thiophene compound and an application thereof. The present invention specifically relates to a compound represented by formula (II) and a pharmaceutically acceptable salt thereof, wherein L1 is —C(═O)— or —C(═O)—NH—; R1 is R1a or aa; ring A is bb or cc; R1a is C1-3 alkyl substituted with 1, 2 or 3 Ra; and R3 is independently H, halogen or C1-3 alkoxy. The compound represented by formula (II) and the pharmaceutically acceptable salt thereof can better inhibit the activity of LSD1, further shows significant inhibitory activity against NCI-H1417 cell proliferation, and has good pharmacokinetic properties (including good oral bioavailability, oral exposure, half-life, and clearance rate, etc.).

公开(公告)号：US20240033278A9

公开(公告)日：2024-02-01

申请号：US18001429

申请日：2021-06-10

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Ke AN ,  Fei SUN ,  Charles Z. DING ,  Shuhui CHEN

IPC: A61K31/7088 ,  A61K47/54 ,  C12N15/113

CPC classification number: A61K31/7088 ,  A61K47/54 ,  C12N15/113

Abstract: The present application relates to a novel conjugate group linkable to a compound (such as a therapeutic compound), for use in directing the compound to a target in the body. The conjugate group disclosed herein can enable an expression-inhibitory oligonucleotide (such as a RNAi reagent) to target liver cells to regulate gene expression. The conjugate group disclosed herein has a variety of applications when linked to expression-inhibitory oligonucleotides, comprising applications in therapy, diagnosis, target verification, and genome development. A composition comprising the conjugate group disclosed herein can mediate expression of target nucleic acid sequences in liver cells (such as hepatocytes) when linked to expression-inhibitory oligonucleotides, and can be used for treatment of diseases or disorders responding to the gene expression or activity of cells, tissues, or organisms.

公开(公告)号：US20230322745A1

公开(公告)日：2023-10-12

申请号：US18027049

申请日：2021-09-28

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

Inventor： Peng ZHANG ,  Yunfu LUO ,  Feng GAO ,  Shuhui CHEN

IPC: C07D409/14 ,  C07D413/14 ,  C07D491/107 ,  C07D487/04 ,  C07D491/056 ,  C07D491/048

CPC classification number: C07D409/14 ,  C07D413/14 ,  C07D491/107 ,  C07D487/04 ,  C07D491/056 ,  C07D491/048

Abstract: Disclosed are a fused tricyclic derivative and a pharmaceutical application thereof. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230219920A1

公开(公告)日：2023-07-13

申请号：US18009440

申请日：2021-06-07

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Wenyuan QIAN ,  Yonggang LIAO ,  Changqing WEI ,  Zhengying XI ,  Yao XIAO ,  Shuhui CHEN

IPC: C07D333/34 ,  C07D277/36 ,  C07D409/12 ,  A61P19/06

CPC classification number: C07D333/34 ,  C07D277/36 ,  C07D409/12 ,  A61P19/06

Abstract: Disclosed in the present invention is a series of dimethylsulfoximine derivatives, and specifically disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230183221A1

公开(公告)日：2023-06-15

申请号：US17998355

申请日：2021-05-19

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Yunfu LUO ,  Yuyong BA ,  Shuhui CHEN

IPC: C07D405/14

CPC classification number: C07D405/14

Abstract: Disclosed are a series of compounds having pyridine structures or pharmaceutically acceptable salts thereof, and an application thereof in the preparation of drugs for the treatment of related diseases. Specifically, disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230174524A1

公开(公告)日：2023-06-08

申请号：US18000684

申请日：2021-06-17

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Peng LI ,  Chong SU ,  Xiaolin LI ,  Zhi LUO ,  Haiying HE ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC: C07D417/04 ,  A61P27/04

CPC classification number: C07D417/04 ,  A61P27/04

Abstract: An aminopyridine compound that may be used as an aldehyde trapping agent, and specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230056559A1

公开(公告)日：2023-02-23

申请号：US17427185

申请日：2020-01-22

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Xile LIU ,  Charles Z. DING ,  Shuhui CHEN ,  Lihong HU ,  Haiwen WAN

IPC: C07D487/04 ,  C07D401/14 ,  C07D491/052 ,  C07D495/04 ,  C07D491/048 ,  C07D471/14 ,  A61P35/00

Abstract: Disclosed are a pyrimidinyl group-containing tricyclic compound and applications thereof in preparing a cancer-treating medicament. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt of same, or an isomer thereof.

公开(公告)号：US20230044606A1

公开(公告)日：2023-02-09

申请号：US17782850

申请日：2020-12-07

Applicant: MEDSHINE DISCOVERY INC.

Inventor： Yi LI ,  Ning LIU ,  Tao YU ,  Chengde WU ,  Jian LI ,  Shuhui CHEN

IPC: C07D513/20 ,  A61P35/00 ,  A61P1/00

Abstract: A Spiro compound serving as an ERK inhibitor, and an application thereof in preparing a drug for treating an ERK-related disease. The present invention specifically relates to a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.