公开(公告)号：US20240066010A1

公开(公告)日：2024-02-29

申请号：US18117899

申请日：2023-03-06

Applicant: Salix Pharmaceuticals, Ltd.

Inventor： William Forbes

IPC: A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06

CPC classification number: A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

公开(公告)号：US20190231771A1

公开(公告)日：2019-08-01

申请号：US16206570

申请日：2018-11-30

Applicant: Salix Pharmaceuticals, Ltd.

Inventor： Enoch Bortey

IPC: A61K31/485 ,  A61K45/06

CPC classification number: A61K31/485 ,  A61K45/06 ,  A61K2300/00

Abstract: Presented herein are methods for treatment or prevention of opioid induced constipation by administration of oral compositions of methylnaltrexone. The methods are based, at least in part, on the identification of subjects that are particularly susceptible to such treatment and optimal dosages of such oral compositions to treat or prevent opioid induced constipation and, further, to minimize the occurrence of adverse events associated with such treatment.

公开(公告)号：US20180303804A1

公开(公告)日：2018-10-25

申请号：US15922010

申请日：2018-03-15

Applicant: Salix Pharmaceuticals, Ltd

Inventor： William Forbes

IPC: A61K31/437 ,  A61K31/352 ,  A61K31/08 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06 ,  A61K31/395

CPC classification number: A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06 ,  A61K2300/00

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

公开(公告)号：US09949958B2

公开(公告)日：2018-04-24

申请号：US15460704

申请日：2017-03-16

Applicant: Salix Pharmaceuticals, Ltd

Inventor： William Forbes

IPC: A61K31/437 ,  A61K45/06 ,  A61K31/426 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016

CPC classification number: A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06 ,  A61K2300/00

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

公开(公告)号：US20170182013A1

公开(公告)日：2017-06-29

申请号：US15398283

申请日：2017-01-04

Applicant: Salix Pharmaceuticals, Ltd.

Inventor： William Forbes ,  Enoch Bortey

IPC: A61K31/437

CPC classification number: A61K31/437

Abstract: The present invention provides new methods and kits for treating IBS; treating IBS in females; treating IBS in older subjects; and treating IBS in non-white subjects.

公开(公告)号：US09421195B2

公开(公告)日：2016-08-23

申请号：US13914074

申请日：2013-06-10

Applicant: Salix Pharmaceuticals, Ltd

Inventor： William Forbes ,  Kunal Merchant ,  Enoch Bortey ,  Audrey Shaw

IPC: A61K31/40 ,  A61K31/437 ,  A61K31/7016 ,  A61K45/06 ,  G06Q50/22

CPC classification number: A61K31/437 ,  A61K31/7016 ,  A61K45/06 ,  G06Q50/22 ,  Y02A90/22 ,  A61K2300/00

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin. The instant application also provides methods for determining if a subject has a neurological condition or hepatic encephalopathy by determining the critical flicker frequency and/or the venous ammonia level of the subject at two or more time points. The invention further provides methods for treating these subjects.

Abstract translation: 该应用描述了使用胃肠特异性抗生素治疗肝性脑病。 胃肠特异性抗生素的一个例子是利福昔明。 本申请还提供了通过在两个或更多个时间点确定受试者的临界闪烁频率和/或静脉氨水平来确定受试者是否具有神经病症或肝性脑病的方法。 本发明还提供了治疗这些受试者的方法。

公开(公告)号：US20160128990A1

公开(公告)日：2016-05-12

申请号：US14933253

申请日：2015-11-05

Applicant: Salix Pharmaceuticals, Ltd

Inventor： Alan C. Moss

IPC: A61K31/437

CPC classification number: A61K31/437 ,  C07D498/18

Abstract: The present invention provides new methods and kits for the reduction, prevention or inhibition of substrate uptake by non-metastatic, metabolically active cells in a subject who will undergo a position emission tomography (PET) scan.

Abstract translation: 本发明提供了用于减少，预防或抑制将经历位置发射断层摄影（PET）扫描的受试者中非转移性，代谢活性细胞的底物摄取的新方法和试剂盒。

公开(公告)号：US20200061032A1

公开(公告)日：2020-02-27

申请号：US16391438

申请日：2019-04-23

Applicant: Salix Pharmaceuticals, Ltd

Inventor： William Forbes ,  Kunal Merchant ,  Enoch Bortey ,  Audrey Shaw

IPC: A61K31/437 ,  G06Q50/22 ,  A61K45/06 ,  A61K31/7016

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin. The instant application also provides methods for determining if a subject has a neurological condition or hepatic encephalopathy by determining the critical flicker frequency and/or the venous ammonia level of the subject at two or more time points. The invention further provides methods for treating these subjects.

公开(公告)号：US10335397B2

公开(公告)日：2019-07-02

申请号：US15922010

申请日：2018-03-15

Applicant: Salix Pharmaceuticals, Ltd

Inventor： William Forbes

IPC: A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

公开(公告)号：US20170281606A1

公开(公告)日：2017-10-05

申请号：US15460704

申请日：2017-03-16

Applicant: Salix Pharmaceuticals, Ltd

Inventor： William Forbes

IPC: A61K31/437 ,  A61K45/06 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K38/31 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K31/08 ,  A61K31/426

CPC classification number: A61K31/437 ,  A61K31/08 ,  A61K31/352 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/606 ,  A61K31/7016 ,  A61K31/785 ,  A61K38/14 ,  A61K38/31 ,  A61K45/06 ,  A61K2300/00

Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.