-
公开(公告)号：US20240024275A1
公开(公告)日：2024-01-25
申请号：US18144890
申请日：2023-05-09
发明人： Tarek A. Zeidan , Scott Duncan , Christopher P. Hencken , Thomas Andrew Wynn , Carlos N. Sanrame
IPC分类号： C07C233/90
CPC分类号： C07C233/90
摘要： The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
-
公开(公告)号：US10973816B2
公开(公告)日：2021-04-13
申请号：US16595608
申请日：2019-10-08
IPC分类号： A61K31/496 , A61K31/00 , C07D401/12
摘要： Processes for providing depot injections of recrystallized aripiprazole lauroxil in which particles of the aripiprazole lauroxil have a surface area of about 0.50 to about 3.3 m2/g; and crystals of aripiprazole lauroxil produced by such processes.
-
公开(公告)号：US10954250B2
公开(公告)日：2021-03-23
申请号：US14612853
申请日：2015-02-03
IPC分类号： C07D495/04 , A61K47/54
摘要： The present invention relates to compounds of Formula I:
-
公开(公告)号：US20190367501A1
公开(公告)日：2019-12-05
申请号：US16540802
申请日：2019-08-14
IPC分类号： C07D417/12 , C07F9/6558 , C07D215/14 , C07D263/58 , C07D215/00 , C07D215/22 , C07D471/04 , C07D471/14 , C07H19/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D239/553 , C07D239/56
摘要： The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
-
公开(公告)号：US10428058B2
公开(公告)日：2019-10-01
申请号：US16023887
申请日：2018-06-29
IPC分类号： C07D417/12 , C07F9/6558 , C07D215/14 , C07D263/58 , C07D215/00 , C07D215/22 , C07D471/04 , C07D471/14 , C07H19/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D239/553 , C07D239/56
摘要： The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
-
公开(公告)号：US10351529B2
公开(公告)日：2019-07-16
申请号：US16131773
申请日：2018-09-14
IPC分类号： C07D401/12 , C07D215/227 , C07F9/6558 , C07D417/14 , C07D413/14 , C07D413/10 , C07D401/14 , C07D215/22 , A61K31/496 , C07D471/04 , C07D417/12 , C07D263/58 , A61K31/497 , C07D241/04
摘要： Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
-
公开(公告)号：US20190201367A1
公开(公告)日：2019-07-04
申请号：US16145703
申请日：2018-09-28
发明人： Tarek A. Zeidan , Scott Duncan , Christopher P. Hencken , Thomas Andrew Wynn , Carlos N. Sanrame
IPC分类号： A61K31/225 , C07D491/113 , C07D211/06 , C07D207/40 , C07D295/088 , C07D211/38 , C07C317/28 , C07C317/18 , C07D207/06 , C07C233/91 , C07C233/18 , C07C229/16 , C07C219/08 , C07D209/52
CPC分类号： A61K31/225 , C07C219/08 , C07C229/16 , C07C233/18 , C07C233/91 , C07C317/18 , C07C317/28 , C07D207/06 , C07D207/40 , C07D209/52 , C07D211/06 , C07D211/38 , C07D295/088 , C07D491/113
摘要： The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
-
公开(公告)号：US20190084937A1
公开(公告)日：2019-03-21
申请号：US16131773
申请日：2018-09-14
IPC分类号： C07D215/227 , A61K31/497 , C07D263/58 , C07D401/12 , C07D417/12 , C07D471/04 , C07F9/6558 , A61K31/496 , C07D215/22 , C07D401/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D241/04
CPC分类号： C07D215/227 , A61K31/496 , A61K31/497 , C07D215/22 , C07D241/04 , C07D263/58 , C07D401/12 , C07D401/14 , C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/65583
摘要： Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
-
公开(公告)号：US20190031648A1
公开(公告)日：2019-01-31
申请号：US16023887
申请日：2018-06-29
IPC分类号： A61K31/496 , C07F9/6558 , C07D215/14 , C07D263/58 , C07D215/00 , C07D215/22 , C07D417/12 , C07D239/56 , C07D471/14 , C07H19/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D239/553 , C07D471/04
摘要： The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
-
10.发明申请公开(公告)号：US20190015408A1
公开(公告)日：2019-01-17
申请号：US16043721
申请日：2018-07-24
发明人： Wilfredo Morales, JR. , Tarek A. Zeidan , Renato A. Chiarella , Steven G. Wright , Jason M. Perry
IPC分类号： A61K31/496 , C07D401/12 , A61K31/00
摘要： Processes for providing depot injections of recrystallized aripiprazole lauroxil in which particles of the aripiprazole lauroxil have a surface area of about 0.50 to about 3.3 m2/g; and crystals of aripiprazole lauroxil produced by such processes.
-
-
-
-
-
-
-
-
-
搜索结果
82 条记录 (耗时 0.028 秒)
