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    PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES
    8.
    发明申请
    PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES 审中-公开

    公开(公告)号：US20190382413A1

    公开(公告)日：2019-12-19

    申请号：US16221884

    申请日：2018-12-17

    申请人： Alkermes Pharma Ireland Limited

    发明人： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

    IPC分类号： C07D491/113 ,  C07D295/088 ,  C07D211/92 ,  C07D207/408 ,  C07C317/28 ,  C07C317/18 ,  C07C229/18 ,  C07C229/12 ,  C07D207/12 ,  C07D207/40 ,  A61K31/4015

    摘要： The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.