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公开(公告)号：US09617256B2
公开(公告)日：2017-04-11
申请号：US14223971
申请日：2014-03-24
申请人： Achaogen, Inc.
发明人： Heinz E. Moser , Qing Lu , Phillip A. Patten , Dan Wang , Ramesh Kasar , Stephen Kaldor , Brian D. Patterson
IPC分类号： C07D471/04 , C07C259/06 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/16 , C07D207/32 , C07D207/337 , C07D207/46 , C07D207/48 , C07D209/46 , C07D211/08 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/46 , C07D211/94 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/61 , C07D217/22 , C07D217/24 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/26 , C07D233/36 , C07D233/64 , C07D239/26 , C07D239/42 , C07D239/88 , C07D239/90 , C07D241/12 , C07D241/52 , C07D249/08 , C07D261/08 , C07D261/20 , C07D263/32 , C07D263/34 , C07D263/58 , C07D267/10 , C07D271/107 , C07D275/02 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/82 , C07D285/12 , C07D295/092 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/14 , C07D309/04 , C07D309/12 , C07D333/06 , C07D333/24 , C07D333/34 , C07D333/36 , C07D335/02 , C07D413/04 , C07D213/74 , C07D239/70
CPC分类号： C07D471/04 , C07C259/06 , C07C311/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/16 , C07D207/32 , C07D207/337 , C07D207/34 , C07D207/46 , C07D207/48 , C07D209/46 , C07D211/08 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/94 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/74 , C07D217/22 , C07D217/24 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/26 , C07D233/36 , C07D233/64 , C07D239/26 , C07D239/42 , C07D239/70 , C07D239/88 , C07D239/90 , C07D241/08 , C07D241/12 , C07D241/52 , C07D249/08 , C07D261/08 , C07D261/20 , C07D263/32 , C07D263/34 , C07D263/58 , C07D267/10 , C07D271/107 , C07D275/02 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/82 , C07D285/12 , C07D295/092 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/26 , C07D307/14 , C07D309/04 , C07D309/08 , C07D309/12 , C07D333/06 , C07D333/24 , C07D333/34 , C07D333/36 , C07D335/02 , C07D413/04
摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
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公开(公告)号：US09266919B2
公开(公告)日：2016-02-23
申请号：US14334511
申请日：2014-07-17
申请人： Achaogen, Inc.
发明人： James Bradley Aggen , Adam Aaron Goldblum , Martin Sheringham Linsell , Paola Dozzo , Heinz Ernst Moser , Darin James Hildebrandt , Micah James Gliedt
IPC分类号： A61K31/70 , C07H15/236 , A61K31/7036 , C07H15/222
CPC分类号： C07H15/224 , A61K31/7036 , C07H15/222 , C07H15/236 , Y02A50/473
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20190352426A1
公开(公告)日：2019-11-21
申请号：US16322417
申请日：2017-08-02
申请人： Achaogen, Inc.
摘要： The present invention provides anti-plazomicin antibodies and methods of use thereof, e.g., in determining levels of plazomicin in samples from human patients undergoing treatment with plazomicin. Such antibodies are useful, for example, in monitoring plazomicin levels during treatment for an infectious disease.
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公开(公告)号：US20170369426A1
公开(公告)日：2017-12-28
申请号：US15615276
申请日：2017-06-06
申请人： Achaogen, Inc.
发明人： Brian D. Patterson , Qing Lu , James Bradley Aggen , Paola Dozzo , Ramesh Annasaheb Kasar , Martin Sheringham Linsell , Timothy Robert Kane , Micah James Gliedt , Darin James Hildebrandt , Glenn A. McEnroe , Frederick Cohen
IPC分类号： C07C259/06 , C07D333/70 , C07C313/04 , C07C313/12 , C07D213/81 , C07D213/79 , C07D213/64 , C07C323/60 , C07C323/42 , C07C317/50 , C07C317/46 , C07C317/28 , C07D471/04 , C07C2601/02 , C07C2601/04 , C07C2601/08
CPC分类号： C07C259/06 , C07C313/04 , C07C313/12 , C07C317/28 , C07C317/46 , C07C317/50 , C07C323/42 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/64 , C07D213/79 , C07D213/81 , C07D333/70 , C07D471/04
摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
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公开(公告)号：US08822424B2
公开(公告)日：2014-09-02
申请号：US13734729
申请日：2013-01-04
申请人： Achaogen, Inc.
发明人： James Bradley Aggen , Adam Aaron Goldblum , Martin Sheringham Linsell , Paola Dozzo , Heinz Ernst Moser , Darin James Hildebrandt , Micah James Gliedt
IPC分类号： A61K31/70
CPC分类号： C07H15/224 , A61K31/7036 , C07H15/222 , C07H15/236 , Y02A50/473
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，药学上可接受的盐和前药，其中Q 1，Q 2，Q 3，R 8和R 9如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20190031743A1
公开(公告)日：2019-01-31
申请号：US16071898
申请日：2017-01-27
申请人： ACHAOGEN, INC.
发明人： Lee Robert SWEM , Ryan CIRZ , Monica SCHWARTZ , Kristina BENDER , Shuang WU , Felix FINDEISEN , Malavika KANNUSWAMY , Dante RICCI , Ami PATEL
IPC分类号： C07K16/12 , C07K16/00 , G01N33/569 , G01N33/543
摘要： Provided are assays or methods for identifying antibodies that bind to microorganisms, e.g., pathogenic microorganisms, such as bacteria other infectious agents. In some embodiments, the provided methods for identifying an antibody that binds the target microorganism involves gel encapsulation of antibody-producing cells in gel microdroplets with a target microorganism. Also provided are antibodies produced by the method. Also provided are antibodies that bind a conserved region or epitope across variants or species of Acenitobacter.
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公开(公告)号：US09701622B2
公开(公告)日：2017-07-11
申请号：US15179751
申请日：2016-06-10
申请人： Achaogen, Inc.
发明人： Brian D. Patterson , Qing Lu , James Bradley Aggen , Paola Dozzo , Ramesh Annasaheb Kasar , Martin Sheringham Linsell , Timothy Robert Kane , Micah James Gliedt , Darin James Hildebrandt , Glenn A. McEnroe , Frederick Cohen
IPC分类号： C07D213/64 , C07D333/70 , C07D471/04 , C07D213/81 , C07C259/06 , C07D213/79 , C07C313/12 , C07C317/46 , C07C317/50 , C07C323/60 , C07C317/28 , C07C323/42 , C07C313/04
CPC分类号： C07C259/06 , C07C313/04 , C07C313/12 , C07C317/28 , C07C317/46 , C07C317/50 , C07C323/42 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/64 , C07D213/79 , C07D213/81 , C07D333/70 , C07D471/04
摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
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公开(公告)号：US09403758B2
公开(公告)日：2016-08-02
申请号：US14537048
申请日：2014-11-10
申请人： Achaogen, Inc.
发明人： Brian D. Patterson , Qing Lu , James Bradley Aggen , Paola Dozzo , Ramesh Annasaheb Kasar , Martin Sheringham Linsell , Timothy Robert Kane , Micah James Gliedt , Darin James Hildebrandt , Glenn A. McEnroe , Frederick Cohen
IPC分类号： C07D213/81 , C07D213/64 , C07D333/70 , C07C259/06 , C07D213/79 , C07D471/04 , C07C313/12 , C07C317/46 , C07C317/50 , C07C323/60 , C07C317/28 , C07C323/42
CPC分类号： C07C259/06 , C07C313/04 , C07C313/12 , C07C317/28 , C07C317/46 , C07C317/50 , C07C323/42 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/64 , C07D213/79 , C07D213/81 , C07D333/70 , C07D471/04
摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
摘要翻译： 提供式（I）的抗菌化合物：及其立体异构体及其药学上可接受的盐; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 以及这些化合物的制备方法。
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公开(公告)号：US20130217642A1
公开(公告)日：2013-08-22
申请号：US13734729
申请日：2013-01-04
申请人： Achaogen, Inc.
发明人： James Bradley Aggen , Adam Aaron Goldblum , Martin Sheringham Linsell , Paola Dozzo , Heinz Ernst Moser , Darin James Hildebrandt , Micah James Gliedt
IPC分类号： C07H15/236
CPC分类号： C07H15/224 , A61K31/7036 , C07H15/222 , C07H15/236 , Y02A50/473
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20170088549A1
公开(公告)日：2017-03-30
申请号：US15376073
申请日：2016-12-12
申请人： Achaogen, Inc.
发明人： Heinz Ernst MOSER , Qing LU , Phillip A. PATTEN , Dan WANG , Ramesh Annasaheb KASAR , Stephen W. KALDOR , Brian D. PATTERSON
IPC分类号： C07D471/04 , C07D207/06 , C07D295/15 , C07D295/155 , C07D239/26 , C07D241/12 , C07D271/107 , C07D285/12 , C07D205/04 , C07D333/24 , C07D211/34 , C07D211/26 , C07D207/34 , C07D263/32 , C07D217/24 , C07D209/46 , C07D239/88 , C07D217/22 , C07D263/58 , C07D277/82 , C07D261/20 , C07D231/56 , C07D207/12 , C07D207/09 , C07D309/08 , C07D335/02 , C07D211/56 , C07D241/08 , C07D207/46 , C07D233/64 , C07D213/56 , C07D275/02 , C07D261/08 , C07D231/12 , C07C311/08 , C07D413/04 , C07C259/06
CPC分类号： C07D471/04 , C07C259/06 , C07C311/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/16 , C07D207/32 , C07D207/337 , C07D207/34 , C07D207/46 , C07D207/48 , C07D209/46 , C07D211/08 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/94 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/74 , C07D217/22 , C07D217/24 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/26 , C07D233/36 , C07D233/64 , C07D239/26 , C07D239/42 , C07D239/70 , C07D239/88 , C07D239/90 , C07D241/08 , C07D241/12 , C07D241/52 , C07D249/08 , C07D261/08 , C07D261/20 , C07D263/32 , C07D263/34 , C07D263/58 , C07D267/10 , C07D271/107 , C07D275/02 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/82 , C07D285/12 , C07D295/092 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/26 , C07D307/14 , C07D309/04 , C07D309/08 , C07D309/12 , C07D333/06 , C07D333/24 , C07D333/34 , C07D333/36 , C07D335/02 , C07D413/04
摘要： Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
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