公开(公告)号：US20180353434A1

公开(公告)日：2018-12-13

申请号：US15560854

申请日：2016-03-24

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： Kentaro HATANAKA ,  Nobuhiro YAGI ,  Takeshi KUBOYAMA ,  Kaori YAGI ,  Shintaro HOSOE

IPC分类号： A61K9/51 ,  A61K31/7088 ,  C07C219/08 ,  C07C211/63 ,  C07C215/08 ,  C07C217/28 ,  C07C271/16 ,  C07C229/06 ,  C07C233/20 ,  C07C237/08 ,  C07D451/14 ,  C12N15/113

CPC分类号： A61K9/5123 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61P29/00 ,  A61P35/00 ,  C07C211/63 ,  C07C215/08 ,  C07C217/28 ,  C07C219/08 ,  C07C229/06 ,  C07C233/20 ,  C07C237/08 ,  C07C271/16 ,  C07D207/08 ,  C07D207/12 ,  C07D211/22 ,  C07D223/04 ,  C07D295/088 ,  C07D317/28 ,  C07D401/04 ,  C07D451/14 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2320/51

摘要： The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.

公开(公告)号：US20190008975A1

公开(公告)日：2019-01-10

申请号：US16065222

申请日：2016-12-26

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： Shintaro HOSOE ,  Tomoyuki NAOI

IPC分类号： A61K47/54 ,  A61K31/7105 ,  C12N15/113 ,  A61K9/00

摘要： The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as a cationic lipid, and the like.

公开(公告)号：US20170224619A1

公开(公告)日：2017-08-10

申请号：US15322271

申请日：2015-06-30

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： Shintaro HOSOE ,  Tomoyuki NAOI

IPC分类号： A61K9/127 ,  A61K9/00 ,  C07D205/04 ,  A61K31/713

CPC分类号： A61K9/1272 ,  A61K9/0019 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/541 ,  A61K47/545 ,  C07D205/04 ,  C07D207/06 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/344 ,  C12N2320/32 ,  C12N2310/322 ,  C12N2310/3533

摘要： The present invention provides a cationic lipid represented by the formula (I) wherein R1 and R2 each represents alkyl having 8 to 24 carbon atoms or the like; R3 represents a hydrogen atom, alkyl having 1 to 3 carbon atoms, the formula (A) wherein R4 and R5 each represents a hydrogen atom or the like, and n3 represents an integer from 2 to 6, or the formula (B) wherein R6 and R7 each represents a hydrogen atom or the like, and n4 represents an integer from 1 to 6; n1 represents an integer from 0 to 4; and n2 represents an integer from 1 to 4, provided that the case where n1 is 0 and n2 is 1 is excluded, and a composition which contains the cationic lipid and a nucleic acid, or the like.

公开(公告)号：US20180193471A1

公开(公告)日：2018-07-12

申请号：US15740090

申请日：2016-07-15

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： Kazutaka NAGATOMO ,  Kazuhiro MASUDA ,  Minako KANDA ,  Yoji YAMADA ,  Hiroto IWAI ,  Asana MAKINO ,  Shintaro HOSOE ,  Takeshi KUBOYAMA ,  Keiji UEHARA ,  Yasuhiro SUZUKI

IPC分类号： A61K47/54 ,  A61K31/713 ,  C07H21/02 ,  C12N15/113 ,  A61K48/00 ,  A61P7/02 ,  A61P37/02

CPC分类号： A61K47/549 ,  A61K31/713 ,  A61K48/00 ,  A61K48/0016 ,  A61K48/005 ,  A61K48/0075 ,  A61P7/02 ,  A61P37/02 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

摘要： The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target β2GPI mRNA sequence, and the 3′ end or 5′ end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).