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公开(公告)号：US20160333346A1
公开(公告)日：2016-11-17
申请号：US15111704
申请日：2015-01-16
发明人： Yoji YAMADA , Hiroto IWAI , Kazuhiro MASUDA , Minako KANDA
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N15/09 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/30 , C12N2310/3521
摘要： The present invention provides a nucleic acid having activity to suppress expression of β2GPI, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as APS, SLE and the like and thrombosis in hemodialysis.
摘要翻译： 本发明提供具有抑制β2GPI表达的活性的核酸，包含核酸的药物组合物，以及含有APS，SLE等自身免疫性疾病的核酸和血液透析中的血栓形成的预防或治疗药物。
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公开(公告)号：US20180208926A1
公开(公告)日：2018-07-26
申请号：US15744251
申请日：2016-07-13
发明人： Yoji YAMADA , Hiroto IWAI , Kazuhiro MASUDA
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N2310/11
摘要： The present invention aims to provide a novel nucleic acid capable of suppressing expression of β2GPI, as well as a pharmaceutical composition for the prophylaxis or treatment of diseases associated with β2GPI expression. The present invention solves the above-mentioned problem by providing an antisense oligonucleotide having a β2GPI expression suppressive activity, a pharmaceutical composition containing the antisense oligonucleotide, and a prophylactic or therapeutic drug for autoimmune diseases including APS, SLE and the like, and thrombosis in hemodialysis that contains the antisense oligonucleotide and suppresses β2GPI expression.
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公开(公告)号：US20170247701A1
公开(公告)日：2017-08-31
申请号：US15594600
申请日：2017-05-13
发明人： Yoji YAMADA , Hiroto IWAI , Kazuhiro MASUDA , Minako KANDA
IPC分类号： C12N15/113 , A61K31/713 , C12N15/09
CPC分类号： C12N15/113 , A61K31/713 , C12N15/09 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/30 , C12N2310/3521
摘要： The present invention provides a nucleic acid having activity to suppress expression of β2GPI, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as APS, SLE and the like and thrombosis in hemodialysis.
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公开(公告)号：US20170247700A1
公开(公告)日：2017-08-31
申请号：US15594599
申请日：2017-05-13
发明人： Yoji YAMADA , Hiroto IWAI , Kazuhiro MASUDA , Minako KANDA
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N15/09 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/30 , C12N2310/3521
摘要： The present invention provides a nucleic acid having activity to suppress expression of β2GPI, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as APS, SLE and the like and thrombosis in hemodialysis.
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公开(公告)号：US20180193471A1
公开(公告)日：2018-07-12
申请号：US15740090
申请日：2016-07-15
发明人： Kazutaka NAGATOMO , Kazuhiro MASUDA , Minako KANDA , Yoji YAMADA , Hiroto IWAI , Asana MAKINO , Shintaro HOSOE , Takeshi KUBOYAMA , Keiji UEHARA , Yasuhiro SUZUKI
IPC分类号： A61K47/54 , A61K31/713 , C07H21/02 , C12N15/113 , A61K48/00 , A61P7/02 , A61P37/02
CPC分类号： A61K47/549 , A61K31/713 , A61K48/00 , A61K48/0016 , A61K48/005 , A61K48/0075 , A61P7/02 , A61P37/02 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2310/351
摘要： The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target β2GPI mRNA sequence, and the 3′ end or 5′ end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).
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