公开(公告)号：US20180193471A1

公开(公告)日：2018-07-12

申请号：US15740090

申请日：2016-07-15

申请人： Kyowa Hakko Kirin Co., Ltd.

发明人： Kazutaka NAGATOMO ,  Kazuhiro MASUDA ,  Minako KANDA ,  Yoji YAMADA ,  Hiroto IWAI ,  Asana MAKINO ,  Shintaro HOSOE ,  Takeshi KUBOYAMA ,  Keiji UEHARA ,  Yasuhiro SUZUKI

IPC分类号： A61K47/54 ,  A61K31/713 ,  C07H21/02 ,  C12N15/113 ,  A61K48/00 ,  A61P7/02 ,  A61P37/02

CPC分类号： A61K47/549 ,  A61K31/713 ,  A61K48/00 ,  A61K48/0016 ,  A61K48/005 ,  A61K48/0075 ,  A61P7/02 ,  A61P37/02 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

摘要： The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target β2GPI mRNA sequence, and the 3′ end or 5′ end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).