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公开(公告)号：US11999884B2
公开(公告)日：2024-06-04
申请号：US17487148
申请日：2021-09-28
Applicant: Shoei Chemical Inc.
Inventor： David Olmeijer , Ravisubhash Tangirala , Austin Smith
IPC: C09K11/02 , B82Y20/00 , B82Y40/00 , C07C319/18 , C07C323/22 , C09K11/56 , C09K11/74 , C09K11/88
CPC classification number: C09K11/025 , C07C319/18 , C09K11/565 , C09K11/7492 , C09K11/883 , B82Y20/00 , B82Y40/00 , C07C323/22
Abstract: The present invention provides nanostructure compositions and methods of producing nanostructure compositions. The nanostructure compositions comprise a population of nanostructures comprising polythiol ligands with pendant moieties. The polythiol ligand with pendant moieties increase the solubility of the nanostructures in solvents and resins. The present invention also provides nanostructure films comprising the nanostructure compositions and methods of making nanostructure films using the nanostructure compositions.
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公开(公告)号：US20240065264A1
公开(公告)日：2024-02-29
申请号：US18492874
申请日：2023-10-24
Inventor： Joel Robert COATS , James Scott KLIMAVICZ , Jefferson DE OLIVEIRA BARIZON , Gregory Lee TYLKA
IPC: A01N31/04 , A01N31/14 , A01N37/42 , A01N43/84 , C07C49/235 , C07C49/255 , C07C69/757 , C07C323/22 , C07D295/112
CPC classification number: A01N31/04 , A01N31/14 , A01N37/42 , A01N43/84 , C07C49/235 , C07C49/255 , C07C69/757 , C07C323/22 , C07D295/112
Abstract: Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.
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公开(公告)号：US11832613B2
公开(公告)日：2023-12-05
申请号：US17181873
申请日：2021-02-22
Inventor： Joel Robert Coats , James Scott Klimavicz , Jefferson De Oliveira Barizon , Gregory Lee Tylka
IPC: A01N31/04 , C07C49/235 , C07C49/255 , C07C323/22 , A01N37/42 , C07C69/757 , A01N31/14 , A01N43/84 , C07D295/112
CPC classification number: A01N31/04 , A01N31/14 , A01N37/42 , A01N43/84 , C07C49/235 , C07C49/255 , C07C69/757 , C07C323/22 , C07D295/112
Abstract: Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.
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公开(公告)号：US20180155279A1
公开(公告)日：2018-06-07
申请号：US15805390
申请日：2017-11-07
Applicant: Peloton Therapeutics, Inc.
Inventor： Darryl David Dixon , Jonas Grina , John A. Josey , James P. Rizzi , Stephen T. Schlachter , Eli M. Wallace , Bin Wang , Paul Wehn , Rui Xu , Hanbiao Yang
IPC: C07C311/29 , C07D231/56 , C07D213/89 , A61K31/09 , A61K31/10 , C07C43/205 , C07D213/85 , C07D213/65 , C07C381/10 , C07C323/22 , C07C317/48 , C07C317/46 , C07C317/44 , C07C317/42 , C07C317/40 , C07C317/36 , C07C317/34 , C07C317/32 , C07C317/24 , C07C317/22 , C07C313/06 , C07C255/56 , C07C255/54 , C07C205/22 , C07C43/285 , C07C43/263 , C07C43/23 , C07C43/225
CPC classification number: C07D213/85 , A61K31/09 , A61K31/10 , A61K41/0038 , A61P35/00 , C07C43/205 , C07C43/225 , C07C43/23 , C07C43/263 , C07C43/275 , C07C43/285 , C07C43/29 , C07C205/22 , C07C255/54 , C07C255/56 , C07C311/29 , C07C313/06 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/34 , C07C317/36 , C07C317/40 , C07C317/42 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/22 , C07C381/10 , C07C2602/04 , C07C2602/08 , C07C2602/10 , C07C2603/94 , C07D213/65 , C07D213/89 , C07D231/56
Abstract: The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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公开(公告)号：US09796727B2
公开(公告)日：2017-10-24
申请号：US13203494
申请日：2010-02-25
Applicant: Hirokazu Kuwabara , Masaaki Ikeda , Kazuo Takimiya
Inventor： Hirokazu Kuwabara , Masaaki Ikeda , Kazuo Takimiya
IPC: C07C319/14 , C07C323/22 , C07D495/04 , H01L51/00 , H01L51/05
CPC classification number: C07D495/04 , C07C319/14 , H01L51/0005 , H01L51/0074 , H01L51/0541 , H01L51/0545 , C07C323/22
Abstract: A heterocyclic compound represented by formula (1) and a field effect transistor having a semiconductor layer comprising the compound. (In the formula, X1 and X2 each independently represents a sulfur atom or a selenium atom, and R1 and R2 each independently represents a C5-16 alkyl.)
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6.发明申请
公开(公告)号：US20170114062A1
公开(公告)日：2017-04-27
申请号：US15194825
申请日：2016-06-28
Inventor： Jef DeBrabander , Luis Parada
IPC: C07D487/04 , C07D213/16 , C07D207/09 , C07C323/22 , C07D295/13 , C07D401/12 , C07C205/58 , C07D213/70 , C07C255/57 , C07D307/14 , C07D209/48 , C07C235/50 , C07C205/61 , C07D211/14 , C07C271/20 , C07C323/62
CPC classification number: C07D487/04 , C07C205/58 , C07C205/61 , C07C235/50 , C07C255/57 , C07C271/20 , C07C323/22 , C07C323/62 , C07D207/09 , C07D209/48 , C07D211/14 , C07D213/16 , C07D213/70 , C07D295/13 , C07D307/14 , C07D401/12
Abstract: The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.
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公开(公告)号：US09597332B2
公开(公告)日：2017-03-21
申请号：US14957020
申请日：2015-12-02
Applicant: NOVIRA THERAPEUTICS, INC.
Inventor： Austin Chen , Yalda Bravo , Nicholas Stock , Bijan Pedram , Jason Jacintho , Ryan C. Clark
IPC: A61K31/5375 , A61K31/18 , A61K31/196 , A61K31/24 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/397 , A61K31/495 , A61K31/4453 , A61K45/06 , C07C323/62 , C07D309/08 , C07D295/155 , C07D307/16 , C07D305/06 , C07D295/192 , C07D487/10
CPC classification number: C07C323/53 , A61K31/167 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/216 , A61K31/24 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/397 , A61K31/44 , A61K31/4412 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C323/22 , C07C323/25 , C07C323/52 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/18 , C07C2602/20 , C07D213/81 , C07D213/82 , C07D295/084 , C07D295/155 , C07D295/192 , C07D305/06 , C07D307/10 , C07D307/16 , C07D307/18 , C07D309/04 , C07D309/08 , C07D487/10 , A61K2300/00
Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
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公开(公告)号：US09447009B2
公开(公告)日：2016-09-20
申请号：US14010724
申请日：2013-08-27
CPC classification number: C07C45/66 , B01J23/20 , B01J23/92 , B01J38/12 , C07C45/52 , C07C319/18 , Y02P20/584 , C07C47/22 , C07C323/22 , C07C323/52 , C07C323/58
Abstract: A method of preparing acrolein from glycerol or glycerine is disclosed. The method includes dehydrating glycerol or glycerine in the presence of a catalyst consisting of at least (a) a mixed oxide of zirconium and at least one metal, said metal being selected from niobium, tantalum and vanadium, or (b) a zirconium oxide and at least one metal oxide, the metal being selected from niobium, tantalum and vanadium, or (c) a silicon oxide and a mixed oxide of zirconium and at least one metal, the metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon, or (d) a titanium oxide and a mixed oxide of zirconium and at least one metal, said metal being selected from tungsten, cerium, manganese, niobium, tantalum, titanium, vanadium and silicon.
Abstract translation: 公开了从甘油或甘油制备丙烯醛的方法。 所述方法包括在由至少（a）锆和至少一种金属的混合氧化物组成的催化剂存在下脱水甘油或甘油，所述金属选自铌，钽和钒，或（b）氧化锆和 至少一种金属氧化物，所述金属选自铌，钽和钒，或（c）氧化硅和锆与至少一种金属的混合氧化物，所述金属选自钨，铈，锰，铌，钽 ，钛，钒和硅，或（d）二氧化钛和锆与至少一种金属的混合氧化物，所述金属选自钨，铈，锰，铌，钽，钛，钒和硅。
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9.发明授权Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels 有权降低甘油三酯，总胆固醇和低密度脂蛋白血药浓度的方法
公开(公告)号：US09358217B2
公开(公告)日：2016-06-07
申请号：US14540766
申请日：2014-11-13
Applicant: MediciNova, Inc.
Inventor： Kazuko Matsuda
IPC: A01N37/10 , A61K31/19 , A61K31/192
CPC classification number: A61K31/192 , C07C323/22
Abstract: A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.
Abstract translation: 式（I）的化合物或其代谢物，或式（I）化合物或其代谢物的酯或其各自的药学上可接受的盐，其中m，n，X1和X2如本文所定义 可用于降低人类受试者中甘油三酯（TG），总胆固醇（TC）和低密度脂蛋白（LDL）中的一种或多种的血液水平。
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公开(公告)号：US20160151375A1
公开(公告)日：2016-06-02
申请号：US14957020
申请日：2015-12-02
Applicant: NOVIRA THERAPEUTICS, INC.
Inventor： Austin Chen , Yalda Bravo , Nicholas Stock , Bijan Pedram , Jason Jacintho , Ryan C. Clark
IPC: A61K31/5375 , A61K31/196 , C07D309/08 , A61K31/351 , C07D295/155 , C07D307/16 , A61K31/341 , A61K31/24 , C07D305/06 , A61K31/337 , C07C323/67 , A61K31/18 , C07D295/192 , A61K31/4453 , A61K31/495 , C07D487/10 , A61K31/397 , A61K45/06 , C07C323/63
CPC classification number: C07C323/53 , A61K31/167 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/216 , A61K31/24 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/397 , A61K31/44 , A61K31/4412 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C323/22 , C07C323/25 , C07C323/52 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/18 , C07C2602/20 , C07D213/81 , C07D213/82 , C07D295/084 , C07D295/155 , C07D295/192 , C07D305/06 , C07D307/10 , C07D307/16 , C07D307/18 , C07D309/04 , C07D309/08 , C07D487/10 , A61K2300/00
Abstract: The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
Abstract translation: 本发明包括在有需要的个体中抑制，抑制或预防HBV感染的方法，包括向个体施用治疗有效量的至少一种本发明的化合物。
