公开(公告)号：US20250057793A1

公开(公告)日：2025-02-20

申请号：US18720456

申请日：2022-12-15

Applicant: The United States Government as represented by the Department of Veterans Affairs ,  Rush University Medical Center

Inventor： Kalipada Pahan

IPC: A61K31/192 ,  A61K31/045 ,  A61K31/198 ,  A61K31/216 ,  A61K31/222 ,  A61P25/00 ,  A61P25/28

Abstract: Disclosed are salts of benzoic acid and prodrugs thereof for slowing the progression of or reducing the severity of a symptom associated with a nervous system injury in a subject.

公开(公告)号：US12091706B2

公开(公告)日：2024-09-17

申请号：US16965368

申请日：2019-01-29

Applicant: Rush University Medical Center

Inventor： Vineet Gupta ,  Anugraha Rajagopalan

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6806 ,  C12Q1/6818

CPC classification number: C12Q1/6818 ,  C07H21/00 ,  C12Q1/6806

Abstract: Compositions and methods are provided including a plurality of analyte detection agents, each analyte detection agent includes a labile tag operatively coupled to the analyte detection agent, each labile tag includes a signal that is different from each other labile tag and each analyte detection agent targeting a different analyte.

公开(公告)号：US20240287575A1

公开(公告)日：2024-08-29

申请号：US18587523

申请日：2024-02-26

Applicant: Northwestern University ,  Rush University Medical Center

Inventor： Barbara Alice Hanson ,  Igor Koralnik

IPC: C12Q1/6804 ,  A61K31/381 ,  A61K31/403 ,  A61K31/501 ,  C12N15/10 ,  C12Q1/70

CPC classification number: C12Q1/6804 ,  A61K31/381 ,  A61K31/403 ,  A61K31/501 ,  C12N15/1096 ,  C12Q1/70 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present invention provides methods for diagnosing and treating human pegivirus infection and Parkinson's disease.

公开(公告)号：US20240092886A1

公开(公告)日：2024-03-21

申请号：US17767620

申请日：2020-10-09

Applicant: Rush University Medical Center

Inventor： Sasha H. SHAFIKHANI ,  Ruchi ROY

IPC: C07K16/24 ,  A61K9/00 ,  A61P17/02

CPC classification number: C07K16/244 ,  A61K9/0014 ,  A61P17/02 ,  A61K2039/505 ,  C07K2317/76

Abstract: Methods of modulating IL-10 signaling in a diabetic patient are provided. The methods include administering a therapeutically effective amount of an agent that inhibits Interleukin-10 (IL-10) signaling to a wound site. The agent may antagonize IL-10 or IL-10R to inhibit IL-10 signaling. In some aspects the agent is an antibody or antigen-binding fragment that specifically binds to IL-10 or IL-10R.

公开(公告)号：US20240082184A1

公开(公告)日：2024-03-14

申请号：US18261959

申请日：2021-01-20

Applicant: Rush University Medical Center

Inventor： Kalipada Pahan

IPC: A61K31/192 ,  A61K31/07 ,  A61P25/28

CPC classification number: A61K31/192 ,  A61K31/07 ,  A61P25/28

Abstract: The present disclosure generally relates to improved pharmaceutical compositions useful for the treatment of diseases and disorders. More particularly, the disclosure relates to pharmaceutical compositions comprising gemfibrozil and/or cinnamic acid for the treatment of globoid cell leukodystrophy or Krabbe disease.

公开(公告)号：US11844767B2

公开(公告)日：2023-12-19

申请号：US17471619

申请日：2021-09-10

Applicant: Rush University Medical Center

Inventor： Kalipada Pahan ,  Arunava Ghosh

IPC: A61K31/07 ,  A61P25/28 ,  A61K31/192 ,  A61K31/203 ,  A61K9/00

CPC classification number: A61K31/07 ,  A61K31/192 ,  A61K31/203 ,  A61P25/28 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0085

Abstract: The present invention generally relates to compositions and methods for stimulating astroglial uptake and degradation of amyloid-β protein aggregates. One aspect of the invention provides a method of preventing or treating Alzheimer's disease including administrating a clinically effective amount of combination of vitamin A or a derivative thereof and an agonist of proliferator-activated receptor α (“PPARα”) to a human or veterinary subject in need of such treatment.

公开(公告)号：US20230037062A1

公开(公告)日：2023-02-02

申请号：US17036138

申请日：2020-09-29

Applicant: RUSH UNIVERSITY MEDICAL CENTER

Inventor： Kalipada Pahan

IPC: A61K31/616 ,  A61K31/07 ,  A61K31/192 ,  A61K31/22 ,  A61K31/366 ,  A61K45/06 ,  A61K31/203 ,  A61K31/216 ,  A61K31/505 ,  A61K31/404 ,  A61K31/47 ,  A61K31/40 ,  A61K31/222

Abstract: One aspect of the invention provides a method for treatment of a lysosomal storage disorder. The method may include administering to a subject in need of such treatment a composition including a therapeutically effective amount of an agent that mediates upregulation of Transcription Factor EB. In one embodiment, the composition includes a fibrate, such as gemfibrozil or fenofibrate. In another embodiment, the composition also includes all-trans retinoic acid or vitamin A.

公开(公告)号：US11524052B2

公开(公告)日：2022-12-13

申请号：US16966277

申请日：2018-12-28

Applicant: Rush University Medical Center

Inventor： Kalipada Pahan

IPC: A61K38/08 ,  A61K38/16 ,  A61K47/64 ,  A61K9/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61K38/17

Abstract: Methods for treating neurological and other disorders, including autoimmune disorders are described. Also described is a method of treating a disorder in which Toll-like Receptor 2 (TLR2) activation by binding to myeloid differentiation primary response 88 (MyD88) plays a role in disease pathogenesis. Further a method is described that includes the administration of a composition, including a peptide sequence, that inhibits the activation of TLR2 by MyD88.

公开(公告)号：US20220331267A1

公开(公告)日：2022-10-20

申请号：US17640698

申请日：2020-09-02

Applicant: Rush University Medical Center

Inventor： Kalipada PAHAN ,  Avik ROY

IPC: A61K31/05 ,  A61K31/015 ,  A61K31/21 ,  A61K9/70 ,  A61K9/16 ,  A61P25/00

Abstract: Methods of modulating peroxisome proliterator-activated receptor β (PPARβ) activity in a cell in a subject in need thereof are provided. The methods include administering an effective amount of a PPAPβ ligand to the subject where the PPAPβ ligand is selected from 1,3-Di-tertbutyl benzene (DBB), 2,4-Di-tertbutyl phenol (DBP), Methyl palmitate (MePA), 2,6-Di-tertbutyl-4-Methyl Phenol (DBMP), 3,4-Di-tertbutyl-Phenol (3,4-DBP), 2,3-Di-tertbutyl-Phenol (2,3-DBP), and 2,6-Di-tertbutyl-Phenol (2,6-DBP).

公开(公告)号：US11339190B2

公开(公告)日：2022-05-24

申请号：US17133035

申请日：2020-12-23

Applicant: Rush University Medical Center

Inventor： Kalipada Pahan

IPC: C07K7/06 ,  C07K7/08 ,  A61K9/00 ,  A61P31/14 ,  A61K38/10 ,  A61K38/08 ,  A61K38/00

Abstract: Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed.