公开(公告)号：US11518746B2

公开(公告)日：2022-12-06

申请号：US17092123

申请日：2020-11-06

申请人： CV6 Therapeutics (NI) Limited

发明人： Mark Spyvee ,  Robert D. Ladner

IPC分类号： C07D209/48 ,  C07D233/72 ,  C07D233/74 ,  A61P35/00 ,  C07D401/12 ,  C07D403/06 ,  A61K31/4015 ,  A61K31/4166

摘要： Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

公开(公告)号：US20190367461A1

公开(公告)日：2019-12-05

申请号：US16540556

申请日：2019-08-14

申请人： JIANFENG CAI ,  MA SU ,  ALEKHYA NIMMAGADDA ,  PENG TENG

发明人： JIANFENG CAI ,  MA SU ,  ALEKHYA NIMMAGADDA ,  PENG TENG

IPC分类号： C07D233/72

摘要： The present disclosure provides compositions including a hydantoin derivative compound, pharmaceutical compositions including a hydantoin derivative compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

公开(公告)号：US10266485B2

公开(公告)日：2019-04-23

申请号：US16005286

申请日：2018-06-11

申请人： ModernaTX, Inc.

发明人： Kerry E. Benenato

IPC分类号： A61K48/00 ,  A61K9/127 ,  C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K9/16 ,  A61K38/18 ,  C07K14/505 ,  A61K9/00 ,  A61K47/54 ,  A61K47/69 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US09849131B2

公开(公告)日：2017-12-26

申请号：US15348091

申请日：2016-11-10

申请人： AUTIFONY THERAPEUTICS LIMITED

发明人： Giuseppe Alvaro ,  Anne Decor ,  Stefano Fontana ,  Dieter Hamprecht ,  Charles Large ,  Agostino Marasco

IPC分类号： A61K31/506 ,  C07D233/76 ,  C07D401/04 ,  C07D403/04 ,  C07D239/22 ,  C07D239/47 ,  C07D233/72 ,  A61K31/4166 ,  A61K31/4439 ,  C07D213/643

CPC分类号： A61K31/506 ,  A61K31/4166 ,  A61K31/4439 ,  C07D213/643 ,  C07D233/72 ,  C07D233/76 ,  C07D239/22 ,  C07D239/47 ,  C07D401/04 ,  C07D403/04

摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.

公开(公告)号：US20170204085A1

公开(公告)日：2017-07-20

申请号：US15454331

申请日：2017-03-09

申请人： Exigence Technologies Inc.

发明人： Song LIU

IPC分类号： C07D403/12 ,  C07D403/14 ,  A01N43/647 ,  C07D233/72 ,  A01N43/50

CPC分类号： C07D403/12 ,  A01N33/12 ,  A01N35/02 ,  A01N43/50 ,  A01N43/647 ,  C07D233/72 ,  C07D233/82 ,  C07D401/12 ,  C07D403/14 ,  C07F9/6506 ,  Y10T442/30 ,  Y10T442/40 ,  Y10T442/60 ,  A01N59/00

摘要： Biocidally active cationic analogs of N-halamine having two biocidally active groups covalently bonded together in a single molecule and having general Formula (I). Compounds of Formula (I), and precursurs thereof, can be in solution form or immobilized onto a substrate via physical coating or covalent chemical bonding to functionalize surfaces or added into materials as additives so as to render them biocidal. The biocidal solutions and substrates comprising the compounds or precursors of the present invention can then be used to inactivate pathogenic microorganisms.

公开(公告)号：US20160368905A1

公开(公告)日：2016-12-22

申请号：US15141556

申请日：2016-04-28

申请人： AbbVie Inc.

发明人： David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

IPC分类号： C07D409/10 ,  A61K31/513 ,  C07D213/64 ,  A61K31/4418 ,  C07C311/08 ,  A61K31/18 ,  C07D233/72 ,  A61K31/4166 ,  A61K31/27 ,  C07D263/24 ,  A61K31/421 ,  C07D239/10 ,  C07D207/27 ,  A61K31/402 ,  C07D405/10 ,  C07D403/10 ,  A61K45/06 ,  A61K31/425 ,  C07D275/02 ,  C07D239/54

CPC分类号： C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

摘要翻译： 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US09447038B2

公开(公告)日：2016-09-20

申请号：US14546087

申请日：2014-11-18

申请人： SANOFI

发明人： Imre Bata ,  Veronika Bartane Bodor ,  Attila Vasas ,  Peter Buzder-Lantos ,  Gyorgy Ferenczy ,  Zsuzsanna Tomoskozi ,  Gabor Szeleczky ,  Zsuzsanna Szamosvolgyi

IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D207/404 ,  C07D233/72 ,  C07D407/12 ,  C07D239/54 ,  C07D233/74

CPC分类号： C07D207/404 ,  C07D233/72 ,  C07D233/74 ,  C07D239/54 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

摘要： The present invention relates to compounds of formula 1 that are useful for the preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.

公开(公告)号：US09346764B2

公开(公告)日：2016-05-24

申请号：US14364147

申请日：2012-12-13

申请人： HINOVA PHARMACEUTICALS INC.

发明人： Yuanwei Chen

IPC分类号： C07D235/02 ,  C07D233/86 ,  A61K31/4166 ,  A61K31/4184 ,  C07D233/72

CPC分类号： C07D235/02 ,  A61K31/4166 ,  A61K31/4184 ,  C07D233/72 ,  C07D233/86

摘要： Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. The imidazolidinedione compounds posses androgen receptor antagonist activity and can be used for preventing and treating diseases and disorders related to androgen receptor, such as prostate cancer, alopecia, hair regeneration, acne and adolescent acne.

摘要翻译： 提供式（I）的咪唑烷二酮化合物，其制备方法，用途及其药物组合物。 咪唑烷二酮化合物具有雄激素受体拮抗剂活性，可用于预防和治疗与雄激素受体有关的疾病和障碍，如前列腺癌，脱发，毛发再生，痤疮和青春期痤疮。

公开(公告)号：US20150118179A1

公开(公告)日：2015-04-30

申请号：US14398926

申请日：2013-05-16

申请人： UNIVERSITY OF MANITOBA

发明人： Song Liu

IPC分类号： A01N43/50 ,  A01N43/647 ,  C07F9/6506 ,  C07D233/72 ,  C07D401/12

CPC分类号： C07D403/12 ,  A01N33/12 ,  A01N35/02 ,  A01N43/50 ,  A01N43/647 ,  C07D233/72 ,  C07D233/82 ,  C07D401/12 ,  C07D403/14 ,  C07F9/6506 ,  Y10T442/30 ,  Y10T442/40 ,  Y10T442/60 ,  A01N59/00

摘要： Biocidally active cationic analogs of N-halamine having two biocidally active groups covalently bonded together in a single molecule and having general Formula (I). Compounds of Formula (I), and precursors thereof, can be in solution form immobilized onto a substrate via physical coating or covalent chemical bonding to functionalize surfaces or added into materials as additives so as to render them biocidal. The biocidal solutions and substrates comprising the compounds or precursors of the present invention can then be used to inactivate pathogenic microorganisms. N-halamine-L-QUAT (I) wherein: the N-halamine may be a cyclic or acyclic N-halamine; L is C1-C6 alkyl, cyclic aromatic or non-aromatic ring, ether, ketone or any other organic linking structures, and QUAT has general formula (II):

摘要翻译： 具有两个生物活性基团的N-卤代胺的生物活性阳离子类似物在单个分子中共价键合在一起并具有通式（I）。 式（I）化合物及其前体可以是通过物理涂层或共价化学键固定在基底上的溶液形式，以将表面官能化或添加到材料中作为添加剂，以使其具有杀生物活性。 包含本发明化合物或前体的杀生物溶液和底物可用于灭活病原微生物。 N-卤胺-L-QUAT（I）其中：N-卤胺可以是环状或非环状N-卤胺; L是C1-C6烷基，环状芳族或非芳族环，醚，酮或任何其他有机连接结构，QUAT具有通式（II）：

公开(公告)号：US08217068B2

公开(公告)日：2012-07-10

申请号：US12598347

申请日：2008-05-05

申请人： Ivan Da Rocha Pitta ,  Maria Do Carmo Alves De Lima ,  Teresinha Gonçalves da Silva ,  Gisele Zapata Sudo ,  Suely Lins Galdino ,  Roberto Takashi Sudo

发明人： Ivan Da Rocha Pitta ,  Maria Do Carmo Alves De Lima ,  Teresinha Gonçalves da Silva ,  Gisele Zapata Sudo ,  Suely Lins Galdino ,  Roberto Takashi Sudo

IPC分类号： A61K31/4166 ,  C07D233/72

CPC分类号： C07D233/74

摘要： The present invention is related to a new series of chemical compounds, namely 3-benzyl-imidazolidine-2,4-dione substituted in the position 2 and/or 6 of benzyl ring by halogens as presented to the molecule named LPSF-PT-31, GIRSUPAN and its therapeutic use as drug with analgesic, sedative and adjuvant of anesthetics activities. The invention is also related to a process for production of said compounds as well as pharmaceutical compositions comprising them.

摘要翻译： 本发明涉及新的一系列化合物，即通过被称为LPSF-PT-31的分子的卤素在苄基的2位和/或6位上被取代的3-苄基 - 咪唑烷-2,4-二酮 ，GIRSUPAN及其作为药物的治疗用途，具有止痛，镇静和佐剂的麻醉活性。 本发明还涉及所述化合物的制备方法以及包含它们的药物组合物。