公开(公告)号：US20240376073A1

公开(公告)日：2024-11-14

申请号：US18404194

申请日：2024-01-04

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra Marie Joseph GRALL-ULSEMER ,  Xingchun HAN ,  Joel Lukas KNECHT ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Patrizio MATTEI ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D401/12 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5355 ,  A61P31/04 ,  C07C53/06 ,  C07C53/10 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/14 ,  C07D487/04

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as described herein: Frther provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230141600A1

公开(公告)日：2023-05-11

申请号：US18076274

申请日：2022-12-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Christian KRAMER ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Sébastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/20 ,  A61K9/48 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

CPC classification number: C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2009 ,  A61K9/4866 ,  A61K9/4858 ,  A61K9/485 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein:




or pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230017532A1

公开(公告)日：2023-01-19

申请号：US17349862

申请日：2021-06-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Sebastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Song YANG

IPC: C07D487/04 ,  C07D519/00

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

公开(公告)号：US20230011869A1

公开(公告)日：2023-01-12

申请号：US17349800

申请日：2021-06-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG

IPC: C07D487/04 ,  C07D519/00

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20200062747A1

公开(公告)日：2020-02-27

申请号：US16346985

申请日：2017-11-01

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Jianhua WANG ,  Min WANG ,  Song YANG

IPC: C07D471/04 ,  A61P31/20

Abstract: The present invention provides novel compounds having the general formula (I) wherein R1, R2 and Z are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20240368117A1

公开(公告)日：2024-11-07

申请号：US18388776

申请日：2023-11-10

Applicant: Hoffmann-La Roche Inc.

Inventor： Mathis BRAENDLIN ,  Sandra Marie Joseph GRALL-ULSEMER ,  Xingchun HAN ,  Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Sébastien SCHMITT ,  Jianhua WANG ,  Yongguang WANG ,  Min WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D401/14 ,  A61P31/04 ,  C07D403/10 ,  C07D403/14

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230373978A1

公开(公告)日：2023-11-23

申请号：US18228924

申请日：2023-08-01

Applicant: Hoffmann-La Roche Inc.

Inventor： Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D403/14 ,  C07D401/14 ,  C07D401/04 ,  A61P31/04

CPC classification number: C07D403/14 ,  C07D401/14 ,  C07D401/04 ,  A61P31/04

Abstract: The invention provides novel heteroaryl-substituted imidazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1 to R6 are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230295123A1

公开(公告)日：2023-09-21

申请号：US18115767

申请日：2023-02-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Christian LERNER ,  Mingming LI ,  Yongqiang LIU ,  Sébastien SCHMITT ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D401/14 ,  C07D471/08 ,  C07D487/08 ,  C07D487/04 ,  A61P31/04

CPC classification number: C07D401/14 ,  A61P31/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R7 are as described herein:





Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230022724A1

公开(公告)日：2023-01-26

申请号：US17349760

申请日：2021-06-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Yongguang WANG ,  Song YANG

IPC: C07D487/04 ,  A61P31/04

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20220396565A1

公开(公告)日：2022-12-15

申请号：US17869755

申请日：2022-07-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Xingchun HAN ,  Christian KRAMER ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Jianhua WANG ,  Lisha WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D403/12 ,  C07D233/90 ,  C07D403/14 ,  C07D487/10 ,  C07D401/14

Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.