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    COMPOSITIONS AND METHODS FOR TREATING EYE DISEASES
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING EYE DISEASES 有权

    公开(公告)号：US20220362282A1

    公开(公告)日：2022-11-17

    申请号：US17624516

    申请日：2020-06-15

    申请人： ADS THERAPEUTICS LLC

    发明人： Jinsong NI ,  Rong YANG

    IPC分类号： A61K31/724 ,  A61K47/02 ,  A61P27/04

    摘要： A method for treating an eye disease of an affected eye includes administering to the affected eye of a subject in need of such treatment a steroidal-androgen-free composition containing a therapeutically effective amount of beta-cyclodextrin derivative. The eye disease can be meibomian gland dysfunction, blepharitis, or dry eye disease. A steroidal-androgen-free composition includes a beta-cyclodextrin derivative as a sole active pharmaceutical ingredient. The steroidal-androgen-free composition is an ophthalmic composition.

    VEGF ANTIBODY-DRUG CONJUGATES
    3.
    发明申请
    VEGF ANTIBODY-DRUG CONJUGATES 有权

    公开(公告)号：US20210030889A1

    公开(公告)日：2021-02-04

    申请号：US17065901

    申请日：2020-10-08

    申请人： ADS Therapeutics LLC

    发明人： Jinsong NI ,  Rong YANG

    IPC分类号： A61K47/68 ,  C07K16/22 ,  A61K9/08 ,  A61K9/00 ,  C07K16/00 ,  A61K31/496 ,  A61K39/395

    摘要： A method of producing synergistic and enhanced efficacy in treating a disease in a subject includes providing an antibody, the antibody being a classic antibody or a modified biologic molecule that blocks a first target in the subject; providing a drug, the drug being a small molecule agent that blocks the first target or a second target in the subject; connecting the antibody and the drug with a linker to form an Antibody-Drug Synergism (ADS) compound; and treating the disease with the ADS compound. The linker is hydrolyzed in the subject over a certain time so that both the antibody and the drug exert their functions simultaneously, and the ADS compound confers better efficacy than either the antibody or the drug alone due to a synergism of the ADS compound.

    OCULAR ANTIBODY-DRUG CONJUGATES
    4.
    发明公开
    OCULAR ANTIBODY-DRUG CONJUGATES 审中-公开

    公开(公告)号：US20230398233A1

    公开(公告)日：2023-12-14

    申请号：US18034710

    申请日：2021-11-03

    申请人： ADS THERAPEUTICS LLC

    发明人： Jinsong NI ,  Rong YANG ,  Wenkui Ken FANG

    IPC分类号： A61K47/68 ,  C07K16/22 ,  A61K31/573 ,  A61K9/00

    CPC分类号： A61K47/6889 ,  C07K16/22 ,  A61K47/6803 ,  A61K47/6845 ,  A61K31/573 ,  A61K9/0048 ,  C07K2317/94

    摘要： An ocular antibody-drug conjugate compound is provided. The compound includes an antibody, the antibody being a classic antibody or a modified biologic molecule that blocks a first target in the subject; a small molecule drug including an alpha agonist or an anti-inflammatory small molecule selected from a steroid, a NSAID, that regulates a second or more target in the subject; and a linker linking the antibody and the small molecule drug. Methods of treating an ocular disease with the antibody drug conjugate compound are also provided. The linker is hydrolyzed in the subject over a certain time so that both the antibody and the steroid exert their functions simultaneously.