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公开(公告)号：US12037324B2
公开(公告)日：2024-07-16
申请号：US17861809
申请日：2022-07-11
发明人： Eldon Scott Priestley , Samuel Kaye Reznik , Edward H. Ruediger , James R. Gillard , Oz Scott Halpern , Wen Jiang , Jeremy Richter , Rejean Ruel , Sasmita Tripathy , Wu Yang , Xiaojun Zhang
IPC分类号： C07D401/14 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P9/04 , C07D233/90 , C07D235/26 , C07D239/20 , C07D257/04 , C07D271/07 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/10
CPC分类号： C07D401/14 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P9/04 , C07D233/90 , C07D235/26 , C07D239/20 , C07D257/04 , C07D271/07 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/10
摘要： The present invention provides compounds of Formula (I):
wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.-
公开(公告)号：US20230124468A1
公开(公告)日：2023-04-20
申请号：US17960199
申请日：2022-10-05
发明人： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US10723723B2
公开(公告)日：2020-07-28
申请号：US16344823
申请日：2017-11-02
发明人： Prashantha Gunaga , Rajeev S. Bhide , Rajesh Onkardas Bora , Manoranjan Panda , Navnath Dnyanoba Yadav , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , A61P13/02 , A61P9/00 , A61P9/12 , A61P9/04 , C07D471/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：USRE49700E1
公开(公告)日：2023-10-17
申请号：US17183286
申请日：2021-02-23
发明人： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
CPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are compounds of Formula (I)
or a salt thereof,
wherein R1 is:
each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.-
公开(公告)号：US09657006B2
公开(公告)日：2017-05-23
申请号：US14897764
申请日：2014-06-11
发明人： Jeremy Richter , J. Alex Bates , Daniel L. Cheney
IPC分类号： C07D401/12 , A61K31/4709 , C07D413/12 , C07D245/04 , C07D255/04
CPC分类号： C07D413/12 , C07D245/04 , C07D255/04 , C07D401/12
摘要： The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.
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公开(公告)号：US11407733B2
公开(公告)日：2022-08-09
申请号：US16311835
申请日：2017-06-28
发明人： Eldon Scott Priestley , Samuel Kaye Reznik , Edward H. Ruediger , James R. Gillard , Oz Scott Halpern , Wen Jiang , Jeremy Richter , Rejean Ruel , Sasmita Tripathy , Wu Yang , Xiaojun Zhang
IPC分类号： C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/14 , C07D417/14 , C07D491/107 , C07D401/10 , C07D235/26 , C07D413/10 , C07D471/04 , C07D257/04 , C07D405/14 , C07D233/90 , C07D498/10 , C07D413/14 , A61P9/04 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , C07D239/20 , C07D271/07
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.
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公开(公告)号：US10851108B2
公开(公告)日：2020-12-01
申请号：US16094288
申请日：2017-04-19
发明人： Prashantha Gunaga , Jeremy Richter , Navnath Dnyanoba Yadav , Manoranjan Panda , Sreenivasulu Godesi
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , C07D271/04 , C07D407/04 , C07D407/06 , C07D413/14 , C07D519/00
摘要： Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20200339550A1
公开(公告)日：2020-10-29
申请号：US16928079
申请日：2020-07-14
发明人： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20190127380A1
公开(公告)日：2019-05-02
申请号：US16094288
申请日：2017-04-19
发明人： Prashantha Gunaga , Jeremy Richter , Navnath Dnyanoba Yadav , Manoranjan Panda , Sreenivasulu Godesi
IPC分类号： C07D487/04 , C07D407/04 , C07D471/04 , C07D407/06 , C07D413/14 , C07D519/00
摘要： Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20240327390A1
公开(公告)日：2024-10-03
申请号：US18659052
申请日：2024-05-09
发明人： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
CPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are compounds of Formula (I)
or a salt thereof,
wherein R1 is:
each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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