- 专利标题： SUBSTITUTED NITROGEN CONTAINING COMPOUNDS
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申请号： US18659052申请日： 2024-05-09
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公开(公告)号： US20240327390A1公开(公告)日： 2024-10-03
- 发明人: Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 优先权： IN 1711019293 2017.06.01 IN 1811004486 2018.02.06
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D487/04
摘要：
Disclosed are compounds of Formula (I)
or a salt thereof,
wherein R1 is:
each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
or a salt thereof,
wherein R1 is:
each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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