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公开(公告)号：USRE49700E1
公开(公告)日：2023-10-17
申请号：US17183286
申请日：2021-02-23
Applicant: Bristol-Myers Squibb Company
Inventor： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC: C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
CPC classification number: C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are compounds of Formula (I)
or a salt thereof,
wherein R1 is:
each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.-
公开(公告)号：US20230124468A1
公开(公告)日：2023-04-20
申请号：US17960199
申请日：2022-10-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC: C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US10723723B2
公开(公告)日：2020-07-28
申请号：US16344823
申请日：2017-11-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Prashantha Gunaga , Rajeev S. Bhide , Rajesh Onkardas Bora , Manoranjan Panda , Navnath Dnyanoba Yadav , Eldon Scott Priestley , Jeremy Richter
IPC: C07D405/14 , C07D413/14 , C07D417/14 , A61P13/02 , A61P9/00 , A61P9/12 , A61P9/04 , C07D471/04
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20200339550A1
公开(公告)日：2020-10-29
申请号：US16928079
申请日：2020-07-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC: C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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5.发明申请NOVEL SUBSTITUTED PYRAZOLO-PIPERAZINES AS CASEIN KINASE 1 D/E INHIBITORS 有权新型替代吡唑并吡啶作为CASEIN KINASE 1 D / E抑制剂公开(公告)号：US20150133428A1
公开(公告)日：2015-05-14
申请号：US14541343
申请日：2014-11-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mettu Mallikarjuna Rao , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC: C07D487/04 , C07D487/10 , C07D491/20 , C07D491/147
CPC classification number: C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）的化合物抑制蛋白激酶活性，从而使它们用作抗癌剂。
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Patent Agency Ranking
公开(公告)号：US11161837B2
公开(公告)日：2021-11-02
申请号：US16083972
申请日：2017-03-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanappa , Kumaravel Selvakumar , Samayamunthula Venkata Satya Arun Kumar Gupta
IPC: C07D405/12 , C07D307/84 , C07D413/12 , A61K31/343 , A61K31/4245 , A61K31/506 , A61P31/00 , A61P31/14
Abstract: The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20200291002A1
公开(公告)日：2020-09-17
申请号：US16083972
申请日：2017-03-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanappa , Kumaravel Selvakumar , Samayamunthula Venkata Satya Arun Gupta
IPC: C07D405/12 , C07D307/84 , C07D413/12
Abstract: The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20180022723A1
公开(公告)日：2018-01-25
申请号：US15551017
申请日：2016-02-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kap-Sun Yeung , John F. Kadow , Rajesh Onkardas Bora , Prakash Anjanapa , Samayamunthula Venkata Satya Arun Kumar
IPC: C07D307/84 , C07D417/12 , C07D413/12 , C07B59/00 , C07D405/12
CPC classification number: C07D307/84 , C07B59/002 , C07B2200/05 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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![Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors](/abs-image/US/2017/03/21/US09598423B2/abs.jpg.150x150.jpg)
9.发明授权公开(公告)号：US09598423B2
公开(公告)日：2017-03-21
申请号：US15034217
申请日：2014-11-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mallikarjuna Rao Mettu , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC: A61K31/498 , C07D487/04 , C07D491/147 , C07D487/10 , C07D491/20 , C07D487/20 , C07D519/00
CPC classification number: C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US20240327390A1
公开(公告)日：2024-10-03
申请号：US18659052
申请日：2024-05-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC: C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
CPC classification number: C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are compounds of Formula (I)
or a salt thereof,
wherein R1 is:
each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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