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公开(公告)号：US20200095214A1
公开(公告)日：2020-03-26
申请号：US16445768
申请日：2019-06-19
Applicant: Imago Biosciences, Inc.
Inventor： John M. MCCALL , Hugh Y. RIENHOFF, Jr. , Michael CLARE
IPC: C07D295/192 , C07C237/22 , C07D213/81 , C07D233/90 , C07D295/185 , C07D295/26 , A61K31/166 , A61K31/40 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , C07D215/14
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20210147373A1
公开(公告)日：2021-05-20
申请号：US17108663
申请日：2020-12-01
Applicant: Imago Biosciences, Inc.
Inventor： John M. MCCALL , Hugh Y. RIENHOFF, JR. , Michael CLARE
IPC: C07D295/192 , C07C237/22 , C07D213/81 , C07D233/90 , C07D295/185 , C07D295/26 , A61K31/166 , A61K31/40 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , C07D215/14
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20200283397A1
公开(公告)日：2020-09-10
申请号：US16672083
申请日：2019-11-01
Applicant: Imago Biosciences, Inc.
Inventor： Hugh Y. RIENHOFF, JR. , John M. MCCALL , Michael CLARE , Cassandra CELATKA , Amy E. TAPPER
IPC: C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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Patent Agency Ranking
公开(公告)号：US20220025424A1
公开(公告)日：2022-01-27
申请号：US16326498
申请日：2017-08-16
Applicant: Imago Biosciences, Inc.
Inventor： Amy E. TAPPER , Cassandra CELATKA , Arthur Glenn ROMERO , John M. MCCALL , Toni CHANCELLOR , He ZHAO , Betina BIOLATTO , Jian-Xie CHEN , Elisabeth C.A. BROT , Peter C. MICHELS , Venkat K. CHARI , Ian C. COTTERILL
Abstract: The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.
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公开(公告)号：US20180312474A1
公开(公告)日：2018-11-01
申请号：US15952073
申请日：2018-04-12
Applicant: Imago Biosciences, Inc.
Inventor： Hugh Y. RIENHOFF, Jr. , John M. MCCALL , Michael CLARE , Cassandra CELATKA , Amy E. TAPPER
IPC: C07D249/06 , A61K31/501 , C07D237/08 , A61K31/551 , A61K31/4995 , C07D487/08 , A61K31/4162 , C07D487/04 , A61K31/41 , C07D401/04 , A61K31/435 , C07D471/10 , A61K31/5383 , C07D498/08 , A61K31/5377 , C07D413/12 , C07D491/107 , C07D239/42 , A61K31/445 , C07D211/66 , A61K31/4196 , C07D249/08 , A61K31/454 , C07D401/12 , A61K31/4192 , C07D403/12 , A61K31/541 , C07D263/32 , C07D231/12 , C07D215/54 , C07D295/26 , A61K31/397 , C07D205/04 , A61K31/54 , C07D279/12 , A61K31/495 , C07D295/192 , A61K31/506 , C07D239/26 , A61K31/496 , C07C309/30 , C07B59/00 , C07C53/18 , A61K9/00 , A61P43/00 , A61P35/02 , A61P35/00 , A61P29/00 , A61K45/06 , A61K9/48 , A61K9/16
CPC classification number: C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20170334873A1
公开(公告)日：2017-11-23
申请号：US15667166
申请日：2017-08-02
Applicant: Imago Biosciences, Inc.
Inventor： John M. MCCALL , Hugh Y. RIENHOFF, JR. , Michael CLARE
IPC: C07D295/192 , C07D295/185 , C07D233/90 , C07D215/14 , C07D213/81 , C07C237/22 , A61K31/54 , A61K31/5375 , A61K31/495 , A61K31/47 , A61K31/4545 , A61K31/454 , A61K31/4453 , A61K31/40 , A61K31/166 , C07D295/26 , C07C2601/02
CPC classification number: C07D295/192 , A61K31/166 , A61K31/40 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , C07C237/22 , C07C2601/02 , C07D213/81 , C07D215/14 , C07D233/90 , C07D295/185 , C07D295/26
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20210139437A1
公开(公告)日：2021-05-13
申请号：US16326495
申请日：2017-08-16
Applicant: Imago Biosciences, Inc.
Inventor： Amy E. TAPPER , Cassandra CELATKA , Arthur Glenn ROMERO , John M. MCCALL , Toni CHANCELLOR , Jian-Xie CHEN , Xuemei CHEN , He ZHAO , Betina BIOLATTO , Elisabeth C.A. BROT , Zhihua LI , Xiaoming LIAO
IPC: C07D249/06 , B01J23/44 , B01J21/18
Abstract: Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.
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公开(公告)号：US20220073477A1
公开(公告)日：2022-03-10
申请号：US17481649
申请日：2021-09-22
Applicant: Imago Biosciences, Inc.
Inventor： Hugh Y. RIENHOFF, JR. , John M. MCCALL , Michael CLARE , Cassandra CELATKA , Amy E. TAPPER
IPC: C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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