公开(公告)号：US20220025424A1

公开(公告)日：2022-01-27

申请号：US16326498

申请日：2017-08-16

Applicant: Imago Biosciences, Inc.

Inventor： Amy E. TAPPER ,  Cassandra CELATKA ,  Arthur Glenn ROMERO ,  John M. MCCALL ,  Toni CHANCELLOR ,  He ZHAO ,  Betina BIOLATTO ,  Jian-Xie CHEN ,  Elisabeth C.A. BROT ,  Peter C. MICHELS ,  Venkat K. CHARI ,  Ian C. COTTERILL

IPC: C12P41/00 ,  C12P13/00 ,  C12N9/04

Abstract: The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.

公开(公告)号：US20210139437A1

公开(公告)日：2021-05-13

申请号：US16326495

申请日：2017-08-16

Applicant: Imago Biosciences, Inc.

Inventor： Amy E. TAPPER ,  Cassandra CELATKA ,  Arthur Glenn ROMERO ,  John M. MCCALL ,  Toni CHANCELLOR ,  Jian-Xie CHEN ,  Xuemei CHEN ,  He ZHAO ,  Betina BIOLATTO ,  Elisabeth C.A. BROT ,  Zhihua LI ,  Xiaoming LIAO

IPC: C07D249/06 ,  B01J23/44 ,  B01J21/18

Abstract: Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.