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公开(公告)号：US20220073477A1
公开(公告)日：2022-03-10
申请号：US17481649
申请日：2021-09-22
Applicant: Imago Biosciences, Inc.
Inventor： Hugh Y. RIENHOFF, JR. , John M. MCCALL , Michael CLARE , Cassandra CELATKA , Amy E. TAPPER
IPC: C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20230293495A1
公开(公告)日：2023-09-21
申请号：US18188578
申请日：2023-03-23
Applicant: Imago Biosciences, Inc.
Inventor： Amy TAPPER , Cassandra CELATKA , Patricia SOULLIAC , Parag VED , Namrata VORA
IPC: A61K31/4192 , A61K9/20
CPC classification number: A61K31/4192 , A61K9/2054 , A61K9/2018
Abstract: Provided is a pharmaceutical composition comprising: N—((S)-5-((1R,2S)-2-(4-fluorophenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl)-4-(1H-1,2,3-triazol-1-yl)benzamide (Compound A), or a pharmaceutically acceptable salt thereof, and at least one stabilizer, pharmaceutical preparations thereof, and methods for the treatment a disease or disorder associated with KDM1A activity.
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公开(公告)号：US20230250090A1
公开(公告)日：2023-08-10
申请号：US18066667
申请日：2022-12-15
Applicant: Imago Biosciences, Inc.
Inventor： Amy E. TAPPER , Cassandra CELATKA , Michael CLARE , Hugh Y. RIENHOFF, JR.
IPC: C07D403/14 , A61K9/00 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
CPC classification number: C07D403/14 , A61K9/0053 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
Abstract: The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
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Patent Agency Ranking
公开(公告)号：US20210139437A1
公开(公告)日：2021-05-13
申请号：US16326495
申请日：2017-08-16
Applicant: Imago Biosciences, Inc.
Inventor： Amy E. TAPPER , Cassandra CELATKA , Arthur Glenn ROMERO , John M. MCCALL , Toni CHANCELLOR , Jian-Xie CHEN , Xuemei CHEN , He ZHAO , Betina BIOLATTO , Elisabeth C.A. BROT , Zhihua LI , Xiaoming LIAO
IPC: C07D249/06 , B01J23/44 , B01J21/18
Abstract: Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.
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公开(公告)号：US20210115023A1
公开(公告)日：2021-04-22
申请号：US17054126
申请日：2019-05-13
Applicant: Imago Biosciences, Inc.
Inventor： Amy E. TAPPER , Cassandra CELATKA , Michael CLARE , Hugh Y. RIENHOFF, Jr.
IPC: C07D403/14 , A61K45/06 , A61K9/00 , C07D241/08 , A61K31/497 , A61K31/5377 , C07D491/107 , A61K31/541 , C07D401/04 , A61K31/506 , C07D403/10 , A61K31/501 , C07D401/14 , C07D403/04
Abstract: The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1 A for the treatment or prevention of diseases. Methods of inhibition of KDM1 A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
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公开(公告)号：US20200283397A1
公开(公告)日：2020-09-10
申请号：US16672083
申请日：2019-11-01
Applicant: Imago Biosciences, Inc.
Inventor： Hugh Y. RIENHOFF, JR. , John M. MCCALL , Michael CLARE , Cassandra CELATKA , Amy E. TAPPER
IPC: C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20220025424A1
公开(公告)日：2022-01-27
申请号：US16326498
申请日：2017-08-16
Applicant: Imago Biosciences, Inc.
Inventor： Amy E. TAPPER , Cassandra CELATKA , Arthur Glenn ROMERO , John M. MCCALL , Toni CHANCELLOR , He ZHAO , Betina BIOLATTO , Jian-Xie CHEN , Elisabeth C.A. BROT , Peter C. MICHELS , Venkat K. CHARI , Ian C. COTTERILL
Abstract: The present disclosure relates to compositions and methods for producing stereoisomerically pure aminocyclopropanes.
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公开(公告)号：US20180312474A1
公开(公告)日：2018-11-01
申请号：US15952073
申请日：2018-04-12
Applicant: Imago Biosciences, Inc.
Inventor： Hugh Y. RIENHOFF, Jr. , John M. MCCALL , Michael CLARE , Cassandra CELATKA , Amy E. TAPPER
IPC: C07D249/06 , A61K31/501 , C07D237/08 , A61K31/551 , A61K31/4995 , C07D487/08 , A61K31/4162 , C07D487/04 , A61K31/41 , C07D401/04 , A61K31/435 , C07D471/10 , A61K31/5383 , C07D498/08 , A61K31/5377 , C07D413/12 , C07D491/107 , C07D239/42 , A61K31/445 , C07D211/66 , A61K31/4196 , C07D249/08 , A61K31/454 , C07D401/12 , A61K31/4192 , C07D403/12 , A61K31/541 , C07D263/32 , C07D231/12 , C07D215/54 , C07D295/26 , A61K31/397 , C07D205/04 , A61K31/54 , C07D279/12 , A61K31/495 , C07D295/192 , A61K31/506 , C07D239/26 , A61K31/496 , C07C309/30 , C07B59/00 , C07C53/18 , A61K9/00 , A61P43/00 , A61P35/02 , A61P35/00 , A61P29/00 , A61K45/06 , A61K9/48 , A61K9/16
CPC classification number: C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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