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    Method for treating a tissue defect with a collagen-containing membrane
    1.
    发明授权
    Method for treating a tissue defect with a collagen-containing membrane 有权

    公开(公告)号：US12226548B2

    公开(公告)日：2025-02-18

    申请号：US18172517

    申请日：2023-02-22

    Applicant: ORTHOCELL LIMITED

    Inventor： Ming Hao Zheng

    IPC: A61L27/24 ,  A61L27/36 ,  A61L27/56 ,  A61L27/58 ,  C07K1/113 ,  C07K14/78 ,  A61F2/18

    Abstract: The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen-containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen-containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.

    SEEDED PRECIPITATION OF POLYPEPTIDES
    8.
    发明公开
    SEEDED PRECIPITATION OF POLYPEPTIDES 审中-公开

    公开(公告)号：US20240228531A9

    公开(公告)日：2024-07-11

    申请号：US18278519

    申请日：2022-02-22

    Applicant: PreOmics GmbH

    Inventor： Nils A. Kulak ,  Sebastian H. Johansson ,  Katrin Hartinger

    IPC: C07K1/30 ,  C07K1/113

    CPC classification number: C07K1/30 ,  C07K1/1136

    Abstract: The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing one or both of the following (i) and (ii): (i) adding solid particulate matter to said sample; and (ii) performing said method in a vessel with a rough surface; wherein steps (a) and (b) can be effected concomitantly or in any order; and wherein said processing or fractionating yields one or more first fractions of proteins, polypeptides and/or peptides as a precipitate on said particulate matter and/or said inhomogeneous surface, and a second fraction of proteins, polypeptides and/or peptides remaining in a supernatant.

    PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS
    10.
    发明公开
    PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS 审中-公开

    公开(公告)号：US20240156976A1

    公开(公告)日：2024-05-16

    申请号：US18352362

    申请日：2023-07-14

    Applicant: ImmunoGen, Inc.

    Inventor： Xinfang LI ,  Jared M. WORFUL

    IPC: A61K47/68 ,  C07K1/113 ,  C07K16/28 ,  C07K16/32

    CPC classification number: A61K47/6803 ,  A61K47/6809 ,  A61K47/6819 ,  A61K47/6849 ,  A61K47/6867 ,  C07K1/113 ,  C07K16/2896 ,  C07K16/32

    Abstract: The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.

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