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公开(公告)号：US11634764B2
公开(公告)日：2023-04-25
申请号：US17121621
申请日：2020-12-14
Applicant: University of Washington , The UAB Research Foundation
Inventor： Jens H. Gundlach , Michael Niederweis , Thomas Z. Butler , Mikhail Pavlenok , Mark A. Troll , Suja Sukumaran
IPC: C07H21/00 , C12N15/00 , A61K39/04 , A61K39/05 , A61K31/7088 , C12Q1/68 , C12Q1/6869 , C12N13/00 , G01N33/68 , G01N33/487 , C07K14/35 , G01N27/447 , A61K39/00 , G01N24/00
Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
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公开(公告)号：US20210040163A1
公开(公告)日：2021-02-11
申请号：US16997032
申请日：2020-08-19
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Michael Niederweis , Mikhail Pavlenok
IPC: C07K14/35 , C12Q1/6869 , G01N27/447 , G01N33/487
Abstract: Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.
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公开(公告)号：US20240391963A1
公开(公告)日：2024-11-28
申请号：US18693641
申请日：2022-09-23
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Michael Niederweis , Mikhail Pavlenok
IPC: C07K14/35 , C07K1/113 , C12P21/02 , C12R1/19 , G01N33/487
Abstract: A preparing a purified population of single chain Mycobacterium smegmatis porins.
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公开(公告)号：US20240174721A1
公开(公告)日：2024-05-30
申请号：US18516332
申请日：2023-11-21
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Michael Niederweis , Mikhail Pavlenok
IPC: C07K14/35 , C12Q1/6869 , G01N27/447 , G01N33/487
CPC classification number: C07K14/35 , C12Q1/6869 , G01N27/44743 , G01N27/44756 , G01N33/48721
Abstract: Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.
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公开(公告)号：US20240124928A1
公开(公告)日：2024-04-18
申请号：US18305770
申请日：2023-04-24
Applicant: University of Washington , The UAB Research Foundation
Inventor： Jens H. Gundlach , Michael Niederweis , Thomas Z. Butler , Mikhail Pavlenok , Mark A. Troll , Suja Sukumaran
IPC: C12Q1/6869 , A61K39/04 , C07K14/35 , C12N13/00 , G01N27/447 , G01N33/487 , G01N33/68
CPC classification number: C12Q1/6869 , A61K39/04 , C07K14/35 , C12N13/00 , G01N27/44704 , G01N27/44791 , G01N33/48721 , G01N33/6872 , A61K39/00
Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
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Patent Agency Ranking
公开(公告)号：US20140308662A1
公开(公告)日：2014-10-16
申请号：US14318072
申请日：2014-06-27
Applicant: UNIVERSITY OF WASHINGTON , THE UAB RESEARCH FOUNDATION
Inventor： Jens H. Gundlach , Michael Niederweis , Thomas Z. Butler , Mikhail Pavlenok , Mark A. Troll , Suja Sukumaran
IPC: C12Q1/68 , G01N27/447
CPC classification number: C12Q1/6869 , A61K39/00 , A61K39/04 , C07K14/35 , C12N13/00 , G01N24/00 , G01N27/44704 , G01N27/44791 , G01N33/48721 , G01N33/6872 , C12Q2523/31 , C12Q2565/631
Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
Abstract translation: 本文提供了耻垢分枝杆菌孔蛋白纳米孔，包含这些纳米孔的体系，以及使用和制备这些纳米孔的方法。 这样的纳米孔可以是野生型MspA孔蛋白，突变MspA孔蛋白，野生型MspA旁系同源孔蛋白，野生型MspA同源孔蛋白，突变MspA旁系同源孔蛋白，突变MspA同源孔蛋白或单链Msp孔蛋白。 还提供能够诱导Msp孔蛋白表达的细菌菌株。
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公开(公告)号：US20220169683A1
公开(公告)日：2022-06-02
申请号：US17674140
申请日：2022-02-17
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Michael Niederweis , Mikhail Pavlenok
IPC: C07K14/35 , C12Q1/6869 , G01N27/447 , G01N33/487
Abstract: Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.
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公开(公告)号：US20190062825A1
公开(公告)日：2019-02-28
申请号：US15996084
申请日：2018-06-01
Applicant: University of Washington , The UAB Research Foundation
Inventor： Jens H. Gundlach , Michael Niederweis , Thomas Z. Butler , Mikhail Pavlenok , Mark A. Troll , Suja Sukumaran
IPC: C12Q1/6869 , A61K39/04 , G01N33/487 , G01N27/447 , G01N33/68 , C12N13/00 , C07K14/35 , A61K39/00 , G01N24/00
Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
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公开(公告)号：US09624275B2
公开(公告)日：2017-04-18
申请号：US14318072
申请日：2014-06-27
Applicant: University of Washington , The UAB Research Foundation
Inventor： Jens H. Gundlach , Michael Niederweis , Thomas Z. Butler , Mikhail Pavlenok , Mark A. Troll , Suja Sukumaran
IPC: A61K39/04 , A61K39/02 , C12Q1/70 , C07K14/35 , C12N13/00 , G01N33/68 , C12Q1/68 , G01N27/447 , G01N33/487
CPC classification number: C12Q1/6869 , A61K39/00 , A61K39/04 , C07K14/35 , C12N13/00 , G01N24/00 , G01N27/44704 , G01N27/44791 , G01N33/48721 , G01N33/6872 , C12Q2523/31 , C12Q2565/631
Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
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公开(公告)号：US09534024B2
公开(公告)日：2017-01-03
申请号：US14216349
申请日：2014-03-17
Applicant: University of Washington , The UAB Research Foundation
Inventor： Jens H. Gundlach , Michael Niederweis , Thomas Z. Butler , Mikhail Pavlenok , Mark A. Troll , Suja Sukumaran
IPC: C07H21/02 , C07H21/04 , A61K39/04 , C07K14/35 , C12N13/00 , G01N33/68 , C12Q1/68 , G01N27/447 , G01N33/487
CPC classification number: C12Q1/6869 , A61K39/00 , A61K39/04 , C07K14/35 , C12N13/00 , G01N24/00 , G01N27/44704 , G01N27/44791 , G01N33/48721 , G01N33/6872 , C12Q2523/31 , C12Q2565/631
Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
Abstract translation: 本文提供了耻垢分枝杆菌孔蛋白纳米孔，包含这些纳米孔的体系，以及使用和制备这些纳米孔的方法。 这样的纳米孔可以是野生型MspA孔蛋白，突变MspA孔蛋白，野生型MspA旁系同源孔蛋白，野生型MspA同源孔蛋白，突变MspA旁系同源孔蛋白，突变MspA同源孔蛋白或单链Msp孔蛋白。 还提供能够诱导Msp孔蛋白表达的细菌菌株。
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