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公开(公告)号：US20230041349A1
公开(公告)日：2023-02-09
申请号：US17858629
申请日：2022-07-06
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li
IPC: C07K14/71 , C12P21/06 , C07K1/113 , C07K1/16 , C07K1/36 , C12N5/00 , C07K1/18 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80
Abstract: The present disclosure pertains to compositions comprising anti-VEGF and methods for producing such compositions in chemically defined media and controlling amounts of certain oxidized aflibercept variants.
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公开(公告)号：US11505594B2
公开(公告)日：2022-11-22
申请号：US17711723
申请日：2022-04-01
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li , Matthew Franklin , Shawn Lawrence , Amy Johnson , Meghan Casey , Jaimie Grapel
IPC: C07K1/16 , C07K1/36 , C07K1/18 , C07K14/71 , C12P21/06 , C07K1/113 , C12N5/00 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80 , G01N30/02
Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号：US20220033472A1
公开(公告)日：2022-02-03
申请号：US17492440
申请日：2021-10-01
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li , Matthew Franklin
IPC: C07K14/71 , C12P21/06 , C07K1/113 , C07K1/16 , C07K1/36 , C12N5/00 , C07K1/18 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80
Abstract: The present disclosure pertains compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号：US20220009999A1
公开(公告)日：2022-01-13
申请号：US17489495
申请日：2021-09-29
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li
IPC: C07K14/71 , C12P21/06 , C07K1/113 , C07K1/16 , C07K1/36 , C12N5/00 , C07K1/18 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80
Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号：US11174283B2
公开(公告)日：2021-11-16
申请号：US17205745
申请日：2021-03-18
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li
Abstract: The present disclosure pertains to compositions comprising aflibercept and methods for producing such compositions in chemically defined media and using chromatography to reduce amounts of certain aflibercept variants.
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Patent Agency Ranking
公开(公告)号：US12054533B2
公开(公告)日：2024-08-06
申请号：US17858629
申请日：2022-07-06
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li
IPC: C07K1/36 , A61K38/18 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K14/71 , C07K16/22 , C07K16/28 , C12N5/00 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , G01N30/02
CPC classification number: C07K14/71 , A61K38/1866 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/283 , C12N5/0018 , C12N5/0031 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , C07K2317/622 , C07K2319/30 , C07K2319/33 , C12N2800/10 , G01N2030/027
Abstract: The present disclosure pertains to methods for producing aflibercept from a host cell cultured in a chemically defined medium (CDM) including purification of aflibercept, wherein aflibercept following purification includes aflibercept variants that have at least one oxidized amino acid residue selected from the group consisting of tryptophan, histidine and a combination thereof.
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公开(公告)号：US20230331776A1
公开(公告)日：2023-10-19
申请号：US18175852
申请日：2023-02-28
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： John Mattila , Xiaolin Tang , Hanne Bak , Shawn M. Lawrence , Amy S. Johnson , Meghan Casey , Michelle LaFond , Andrew Tustian , Philip Mellors , John Hourihan , John Crowley , Laura Callinan , Shadia Abike Oshodi , Ashley Witmer , Daniel Corbett , James Reilly , Ankit Vartak , Mark Chiboroski , Alessandra Starling , Robert Stairs , Hai-Yuan Goh , Liam Nicholl , Aishling Conlon
IPC: C07K1/36
CPC classification number: C07K1/36 , C07K2317/565 , C07K2317/14
Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.
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公开(公告)号：US11649273B2
公开(公告)日：2023-05-16
申请号：US17575585
申请日：2022-01-13
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal
IPC: C07K1/36 , C07K14/71 , C12P21/06 , C07K1/113 , C07K1/16 , C12N5/00 , C07K1/18 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80 , G01N30/02
CPC classification number: C07K14/71 , A61K38/1866 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/283 , C12N5/0018 , C12N5/0031 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , C07K2317/622 , C07K2319/30 , C07K2319/33 , C12N2800/10 , G01N2030/027
Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号：US20220275054A1
公开(公告)日：2022-09-01
申请号：US17575585
申请日：2022-01-13
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal
IPC: C07K14/71 , C12P21/06 , C07K1/113 , C07K1/16 , C07K1/36 , C12N5/00 , C07K1/18 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80
Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号：US11407813B2
公开(公告)日：2022-08-09
申请号：US17492440
申请日：2021-10-01
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li , Matthew Franklin
IPC: C07K1/16 , C07K1/36 , C07K14/71 , C12P21/06 , C07K1/113 , C12N5/00 , C07K1/18 , C07K1/22 , C12P21/02 , A61K38/18 , C07K16/28 , C12N15/66 , C07K16/22 , G01N30/80 , G01N30/02
Abstract: The present disclosure pertains compositions comprising anti-VEGF proteins and methods for producing such compositions.
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