公开(公告)号：US20220125891A1

公开(公告)日：2022-04-28

申请号：US15734885

申请日：2019-06-06

申请人： OSAKA UNIVERSITY ,  CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Shizuo AKIRA ,  Takashi SATOH ,  Hiroki TANAKA ,  Keiko SAITO ,  Yusuke YAMAGISHI

IPC分类号： A61K38/45 ,  A61K38/17 ,  C07K16/40 ,  C07K7/64 ,  A61P17/06 ,  C12Q1/48 ,  G01N33/573 ,  A61P13/12 ,  A61P17/02 ,  A61P27/02 ,  A61P37/06 ,  A61P25/00

摘要： The present invention found that, for example, inhibiting phosphorylation of a Ser residue in Regnase-1 is effective in treating and/or preventing diseases. The invention also found that, for example, inhibiting the binding of Regnase-1 with at least one factor selected from the group consisting of TBK1, IKKi, Act-1, IKK, and IRAK is effective in treating and/or preventing diseases.

公开(公告)号：US20210087572A1

公开(公告)日：2021-03-25

申请号：US17024944

申请日：2020-09-18

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Atsushi OHTA ,  Yusuke YAMAGISHI ,  Atsushi MATSUO

IPC分类号： C12N15/70 ,  C12P19/34 ,  C12N9/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12N9/22 ,  C12P21/02

摘要： The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.

公开(公告)号：US20240166689A1

公开(公告)日：2024-05-23

申请号：US18460300

申请日：2023-09-01

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Shiori KARIYUKI ,  Takeo IIDA ,  Miki KOJIMA ,  Ryuichi TAKEYAMA ,  Mikimasa TANADA ,  Tetsuo KOJIMA ,  Hitoshi IIKURA ,  Atsushi MATSUO ,  Takuya SHIRAISHI ,  Takashi EMURA ,  Kazuhiko NAKANO ,  Koji TAKANO ,  Kousuke ASOU ,  Takuya TORIZAWA ,  Ryusuke TAKANO ,  Nozomi HISADA ,  Naoaki MURAO ,  Atsushi OHTA ,  Kaori KIMURA ,  Yusuke YAMAGISHI ,  Tatsuya KATO

IPC分类号： C07K7/64 ,  C07H21/04 ,  C07K1/113 ,  C07K5/087 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08 ,  C07K11/00 ,  C07K11/02 ,  C07K19/00 ,  C12P21/02

CPC分类号： C07K7/64 ,  C07H21/04 ,  C07K1/113 ,  C07K5/0812 ,  C07K5/1013 ,  C07K7/06 ,  C07K7/08 ,  C07K11/00 ,  C07K11/02 ,  C07K19/00 ,  C12P21/02 ,  A61K38/00

摘要： An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

公开(公告)号：US20180127761A1

公开(公告)日：2018-05-10

申请号：US15557532

申请日：2016-03-11

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Atsushi OHTA ,  Yusuke YAMAGISHI ,  Atsushi MATSUO

IPC分类号： C12N15/70 ,  C12N9/00 ,  C12N9/22 ,  C12P19/34 ,  C12P21/02

摘要： The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan, and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.