公开(公告)号：US20220064218A1

公开(公告)日：2022-03-03

申请号：US17422940

申请日：2020-01-15

申请人： BicycleTx Limited

发明人： Leonardo BALDASSARRE ,  Rachid LANI ,  Silvia PAVAN ,  Catherine STACE ,  Daniel TEUFEL

IPC分类号： C07K7/08 ,  A61K47/64

摘要： The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD38.The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and dmg conjugates in preventing, suppressing or treating a disease or disorder mediated by CD38.

公开(公告)号：US20210101933A1

公开(公告)日：2021-04-08

申请号：US17080021

申请日：2020-10-26

申请人： BicycleTx Limited

发明人： Liuhong CHEN ,  Rachid LANI ,  Kevin MCDONNELL ,  Gemma MUDD ,  Peter U. PARK ,  Punit UPADHYAYA

IPC分类号： C07K7/08 ,  A61K47/59 ,  A61K47/60 ,  A61K47/64 ,  A61K47/66 ,  A61P35/00 ,  C07K7/64 ,  C07K14/705 ,  C07K17/02 ,  C07K17/14 ,  C07K2/00

摘要： The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

公开(公告)号：US20230220008A1

公开(公告)日：2023-07-13

申请号：US18055255

申请日：2022-11-14

申请人： BicycleTx Limited

发明人： Liuhong CHEN ,  Rachid LANI ,  Kevin MCDONNELL ,  Gemma MUDD ,  Peter U. PARK ,  Punit UPADHYAYA

IPC分类号： C07K7/08 ,  C07K17/02 ,  A61K47/59 ,  C07K14/705 ,  A61K47/66 ,  A61K47/60 ,  C07K2/00 ,  A61K47/64 ,  C07K17/14 ,  C07K7/64 ,  A61P35/00 ,  A61K47/54

CPC分类号： C07K7/08 ,  C07K17/02 ,  A61K47/59 ,  C07K14/70575 ,  A61K47/66 ,  A61K47/60 ,  C07K2/00 ,  A61K47/64 ,  C07K17/14 ,  C07K7/64 ,  A61P35/00 ,  A61K47/54 ,  C07K2319/00

摘要： The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

公开(公告)号：US20220213145A1

公开(公告)日：2022-07-07

申请号：US17648560

申请日：2022-01-21

申请人： BicycleTx Limited

发明人： Liuhong CHEN ,  Rachid LANI ,  Kevin MCDONNELL ,  Gemma Elizabeth MUDD ,  Peter PARK

IPC分类号： C07K7/64 ,  A61K47/64

摘要： The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

公开(公告)号：US20220064221A1

公开(公告)日：2022-03-03

申请号：US17422935

申请日：2020-01-15

申请人： BicycleTx Limited

发明人： Rachid LANI ,  Catherine STACE ,  Daniel TEUFEL ,  Edward WALKER

IPC分类号： C07K7/60 ,  C07K7/64 ,  A61K47/64 ,  C07K19/00

摘要： The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of integrin αvβ3. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by integrin αvβ3.

公开(公告)号：US20220088118A1

公开(公告)日：2022-03-24

申请号：US17422932

申请日：2020-01-15

申请人： BicycleTx Limited

发明人： Leonardo BALDASSARRE ,  Liuhong CHEN ,  Rachid LANI ,  Catherine STACE ,  Daniel TEUFEL ,  Edward WALKER

IPC分类号： A61K38/12 ,  A61K47/54 ,  A61K45/06

摘要： The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of carbonic anhydrase IX (CAIX). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CAIX.

公开(公告)号：US20220024982A1

公开(公告)日：2022-01-27

申请号：US17309626

申请日：2019-12-13

申请人： BicycleTx Limited

发明人： Liuhong CHEN ,  Euan RICHARDS ,  Rachid LANI ,  Gemma MUDD ,  Catherine STACE ,  Daniel TEUFEL ,  Edward WALKER

IPC分类号： C07K7/64 ,  A61K47/64

摘要： The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.